Dicarboxylic Acids

Name
Dicarboxylic Acids
Accession Number
DBCAT000327
Description

Acyclic acids that contain two carboxyl groups and have the formula HO2C-R-CO2H, where R may be an aromatic or aliphatic group.

Drugs
DrugDrug Description
Succinic acidFor nutritional supplementation, also for treating dietary shortage or imbalance
SuccinylcholineA depolarizing skeletal muscle relaxant used adjunctly to anesthesia and for skeletal muscle relaxation during intubation, mechanical ventilation, and surgical procedures.
SuccimerA mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning.
Fumaric acidNot Available
Malonic acidNot Available
Glutaric AcidNot Available
Mesoxalic acidNot Available
Oxalic AcidA strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted...
Methylmalonic AcidA malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed...
Maleic acidNot Available
Guanidinoethylmercaptosuccinic acidNot Available
3-hydroxyglutaric acidNot Available
Citraconic acidCitraconic acid is one of the isomeric dicarboxylic acids produced by the distillation of citric acid, or as metabolites by microorganisms, cis-CH3-C(CO2H)=CHCO2H; the trans-isomer is mesaconic acid.
OSI-7904LInvestigated for use/treatment in gastric cancer.
EdonerpicInvestigated for use/treatment in alzheimer's disease.
BevirimatInvestigated for use/treatment in HIV infection.
Oxogluric acidα-α-Ketoglutarate is not approved for any indication in the world but is an investigational drug in the United States. The potential indications for α-Ketoglutarate are in patients with the metabolic...
Dimethyl fumarateA medication used to treat patients with the relapsing-remitting form of multiple sclerosis.
AliskirenA direct renin inhibitor used to manage hypertension.
ArtesunateArtesunate is an artemesinin derivative indicated for the initial treatment of severe malaria.
Sodium aurothiomalateA disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.
L-tartaric acidTartaric Acid is primarily indicated in conditions like Antiscorbutic, Antiseptic.
Iron protein succinylateNot Annotated
RuboxistaurinRuboxistaurin has been investigated for the basic science of Type 2 Diabetes Mellitus and Type 1 Diabetes Mellitus.
LY-2090314Ly2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, and Pancreatic Cancer.
SarpogrelateSarpogrelate has been investigated for the treatment of Diabetes Mellitus, Diabetic Nephropathy, Coronary Artery Disease, and Renal Insufficiency, Chronic.
Malic acidMalic acid has been used in trials studying the treatment of Xerostomia, Depression, and Hypertension.
GranotapideGranotapide has been used in trials studying the treatment of Type II Diabetes Mellitus.
BumadizoneBumadizone has been approved for use in Germany and Austria, it is a drug with anti-inflammatory, antipyretic, and analgesic properties, and was marketed for the treatment of both rheumatoid arthritis...
Sodium tartrateIt acts as an emulsifier and pH control agent in food products , . In the laboratory, it is used while performing the Karl Fischer equation, which is used to...
Monomethyl fumarateNot Annotated
Lithium succinateNot Available
MeglutolAn antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as...
AlbuvirtideAlbuvirtide is under investigation in clinical trial NCT03719664 (Albuvirtide and 3BNC117 as Long-Acting Maintenance Therapy in Virologically Suppressed Subjects).
L-2-aminopimelic acidNot Available
Bisindolylmaleimide VIIINot Available
Bisindolylmaleimide INot Available
Bis(N-maleimidomethyl)etherNot Available
AllysineNot Available
Calcium monoethylfumarateNot Annotated
Zinc monoethylfumarateNot Annotated
CitrullineUsed for nutritional supplementation, also for treating dietary shortage or imbalance.
Calcium citrateAn ingredient found in a variety of supplements and vitamins.
Iron (III) oxide adipateNot Annotated
Succinylated gelatinA plasma volume expander indicated alone or in combination with blood transfusions.
Drugs & Drug Targets
DrugTargetType
Succinic acidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
Succinic acidSuccinate receptor 1target
Succinic acidSolute carrier family 22 member 8transporter
Succinic acidSuccinate dehydrogenase cytochrome b560 subunit, mitochondrialenzyme
Succinic acidSuccinyl-CoA ligase [GDP-forming] subunit beta, mitochondrialenzyme
Succinic acidSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialenzyme
Succinic acidMitochondrial dicarboxylate carriertransporter
Succinic acidProlyl 4-hydroxylaseenzyme
Succinic acidProcollagen-lysine,2-oxoglutarate 5-dioxygenase 3enzyme
Succinic acidSolute carrier family 13 member 1transporter
Succinic acidSolute carrier family 13 member 2transporter
Succinic acidSolute carrier family 13 member 3transporter
Succinic acidProlyl 3-hydroxylase 1enzyme
Succinic acidProlyl 3-hydroxylase 2enzyme
Succinic acidProlyl 3-hydroxylase 3enzyme
Succinic acidSuccinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrialenzyme
Succinic acidAspartyl/asparaginyl beta-hydroxylaseenzyme
SuccinylcholineCholinesteraseenzyme
SuccinylcholineMuscarinic acetylcholine receptor M2target
SuccinylcholineMuscarinic acetylcholine receptor M3target
SuccinylcholineNeuronal Acetylcholine (nACh) Receptor Subunitstarget
SuccimerLeadtarget
SuccimerMercurytarget
SuccimerCadmiumtarget
SuccimerArsenictarget
Fumaric acidMalate dehydrogenasetarget
Fumaric acidFumarate reductase flavoprotein subunittarget
Fumaric acidNAD-dependent malic enzyme, mitochondrialtarget
Fumaric acidFumarylacetoacetasetarget
Fumaric acidFumarate reductase flavoprotein subunittarget
Malonic acidAspartate 1-decarboxylasetarget
Malonic acidProto-oncogene tyrosine-protein kinase Srctarget
Malonic acidSigma factor SigB regulation protein RsbQtarget
Malonic acidPutative cytochrome P450target
Malonic acidU1 small nuclear ribonucleoprotein Atarget
Malonic acidMalonamidase E2target
Malonic acidAcetyl transferasetarget
Glutaric AcidAspartate aminotransferasetarget
Glutaric AcidBranched-chain-amino-acid aminotransferasetarget
Glutaric AcidGlutamate decarboxylase alphatarget
Glutaric AcidSolute carrier family 22 member 6transporter
Glutaric AcidSolute carrier family 22 member 8transporter
Glutaric AcidSolute carrier family 22 member 11transporter
Glutaric AcidSolute carrier family 22 member 7transporter
Mesoxalic acidNAD-dependent malic enzyme, mitochondrialtarget
Oxalic AcidProto-oncogene tyrosine-protein kinase Srctarget
Oxalic AcidSolute carrier organic anion transporter family member 2B1transporter
Oxalic AcidSolute carrier family 22 member 8transporter
Methylmalonic AcidMethylmalonyl-CoA carboxyltransferase 12S subunittarget
Maleic acidAspartate aminotransferasetarget
Maleic acidTrypanothione reductasetarget
Maleic acidAspartate aminotransferasetarget
Maleic acidAromatic-amino-acid aminotransferasetarget
Maleic acidAspartate aminotransferase, cytoplasmictarget
Guanidinoethylmercaptosuccinic acidCarboxypeptidase Dtarget
3-hydroxyglutaric acidHydroxymethylglutaryl-CoA lyase, mitochondrialtarget
Citraconic acidFumarate reductase flavoprotein subunittarget
OSI-7904LThymidylate synthasetarget
EdonerpicAmyloid beta A4 proteintarget
BevirimatGag-Pol polyproteintarget
Oxogluric acidAspartate aminotransferasetarget
Dimethyl fumarateKelch-like ECH-associated protein 1target
Dimethyl fumarateTranscription factor p65target
AliskirenRenintarget
AliskirenCytochrome P450 3A4enzyme
AliskirenP-glycoprotein 1transporter
ArtesunateMalaria protein EXP-1target
ArtesunateCytochrome P450 2A6enzyme
ArtesunateUDP-glucuronosyltransferase 2B7enzyme
ArtesunateUDP-glucuronosyltransferase 1-9enzyme
ArtesunateATP-binding cassette sub-family G member 2transporter
ArtesunateP-glycoprotein 1transporter
ArtesunateSolute carrier organic anion transporter family member 1B1transporter
ArtesunateSolute carrier family 22 member 8transporter
ArtesunateSerum albumincarrier
Sodium aurothiomalateUDP-glucuronosyltransferase 1-1enzyme
Sarpogrelate5-hydroxytryptamine receptor 2Ctarget
Sarpogrelate5-hydroxytryptamine receptor 2Atarget
Lithium succinateInositol monophosphatase 2target
Lithium succinateInositol monophosphatase 1target
Lithium succinateGlycogen synthase kinase-3 betatarget
Lithium succinateGlutamate receptor 3target
Meglutol3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
L-2-aminopimelic acid2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferasetarget
Bisindolylmaleimide VIII3-phosphoinositide-dependent protein kinase 1target
Bisindolylmaleimide VIIIMyotonin-protein kinasetarget
Bisindolylmaleimide ISerine/threonine-protein kinase pim-1target
Bisindolylmaleimide I3-phosphoinositide-dependent protein kinase 1target
Bisindolylmaleimide IProtein kinase C iota typetarget
Bis(N-maleimidomethyl)etherAzurintarget
AllysineGlutaminase-asparaginasetarget
CitrullineNitric oxide synthase, endothelialtarget
CitrullineArgininosuccinate synthasetarget
CitrullineN(G),N(G)-dimethylarginine dimethylaminohydrolase 2target
CitrullineArgininosuccinate synthetase, isoform CRA_atarget
CitrullineN(G),N(G)-dimethylarginine dimethylaminohydrolase 1target
CitrullineOrnithine carbamoyltransferase, mitochondrialtarget
CitrullineNitric oxide synthase, braintarget
CitrullineNitric oxide synthase, inducibletarget
CitrullineProtein-arginine deiminase type-4target
CitrullineProtein-arginine deiminase type-6target
CitrullineProtein-arginine deiminase type-1target
CitrullineProtein-arginine deiminase type-3target
CitrullineProtein-arginine deiminase type-2target
CitrullineSolute carrier family 22 member 6transporter
Calcium citrateTransient receptor potential cation channel subfamily V member 6transporter
Calcium citrateCalbindincarrier
Calcium citrateProtein S100-Gcarrier
Calcium citrateSodium/calcium exchanger 1transporter
Calcium citrateTransient receptor potential cation channel subfamily V member 5transporter
Calcium citrateExtracellular calcium-sensing receptortarget
Calcium citrateCalreticulintarget
Calcium citrateCalcium and integrin-binding protein 1target
Calcium citrateProgrammed cell death protein 6target
Calcium citrateSorcintarget
Calcium citrateCalcineurin B homologous protein 1target
Calcium citrateSPARCtarget
Calcium citrateCalnexintarget
Calcium citrateFibrillin-2target
Calcium citrateProtein S100-Btarget
Calcium citrateCalsequestrin-2target
Calcium citrateRegucalcintarget
Calcium citratePeflintarget
Calcium citrateProtein S100-A6target
Calcium citrateTranslationally-controlled tumor proteintarget
Calcium citrateCalcium and integrin-binding family member 2target
Calcium citrateProtein S100-A13target
Calcium citrateCalsequestrin-1target
Calcium citrateNucleobindin-1target
Calcium citrateNucleobindin-2target
Calcium citrateCalmodulintarget
Calcium citrateFibrillin-3target
Calcium citrateGrancalcintarget
Calcium citrateCalcium-dependent secretion activator 1target
Calcium citrateSerum albumincarrier
Calcium citrateCalmodulin-2target
Calcium citrateCalmodulin-3target
Calcium citrateProtein S100-A16target
Calcium citrateCalretinintarget
Calcium citrateCalcyphosintarget
Calcium citrateCalcium-dependent secretion activator 2target
Calcium citrateCalreticulin-3target
Calcium citrateRyanodine receptor 1transporter
Calcium citrateRyanodine receptor 2transporter
Calcium citratePolycystic kidney disease 2-like 1 proteintransporter
Calcium citrateNeurexin-1target
Calcium citrateNeuronal calcium sensor 1target
Calcium citrateRyanodine receptor 3transporter
Calcium citratePolycystic kidney disease protein 1-like 3transporter
Calcium citrateCation channel sperm-associated protein 1transporter
Calcium citrateVoltage-dependent L-type calcium channeltransporter
Calcium citrateVoltage-dependent P/Q-type calcium channeltransporter
Calcium citrateVoltage-dependent T-type calcium channeltransporter
Calcium citrateVoltage-dependent R-type calcium channeltransporter