Wilson's Disease (DBCOND0032702)

Identifiers

Synonyms
Wilson Disease / Wilson's disease / Hepato-lenticular degeneration / Westphal-Strumpell syndrome (disorder) / Wilson's disease (disorder) / Hepatolenticular Degeneration

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Penicillamine
A chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis.
Triethylenetetramine
A copper chelating agent used for the management of Wilson's disease in cases where penicillamine therapy is clinically inappropriate.
Zinc
An essential element commonly used for the treatment of patients with documented zinc deficiency.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04422431
Copper Concentration & Histopathologic Changes in Liver Biopsy in Participants With Wilson Disease Treated With ALXN1840treatment2completed
NCT05047523
Study of ALXN1840 Versus Standard of Care in Pediatric Participants With Wilson DiseaseNo drug interventionstreatment3terminated
NCT05444127
Oral Health and Wilson's Disease: SOMAWINo drug interventionsNot AvailableNot Availablerecruiting
NCT06650319
A Clinical Study to Evaluate the Safety and Efficacy of LY-M003 Injection in Patients with Wilson DiseaseNo drug interventionstreatment0enrolling_by_invitation
NCT06573723
Institutional Registry of Rare DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT05686564
Early Access Program for ALXN1840 in Patients With Wilson DiseaseNot AvailableNot Availableno_longer_available
NCT05783687
Real World Evidence Study in Subjects With Wilson's DiseaseNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04884815
Study of UX701 Gene Transfer for the Treatment of Wilson DiseaseNo drug interventionstreatment1 / 2active_not_recruiting
NCT03539952
Trientine Tetrahydrochloride (TETA 4HCL) for the Treatment of Wilson's Diseasetreatment3completed
NCT04408300
Study of Retinal Vascular Parameters in Patients With Wilson's DiseaseNo drug interventionsotherNot Availablecompleted
NCT00004339
Study of Tetrathiomolybdate in Patients With Wilson Diseasetreatment3completed
NCT01472874
Single Daily Dosage of Trientine for Maintenance Treatment for Wilson DiseasetreatmentNot Availablecompleted
NCT03589820
Plasma Exchange and Continuous Hemodiafiltration in Treatment of Wilson's Disease-related Liver FailureNo drug interventionstreatmentNot Availableunknown_status
NCT03334292
Natural History of Wilson DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT04910581
rTMS in Wilson Disease DysarthriaNo drug interventionstreatmentNot Availablecompleted
NCT03655223
Early Check: Expanded Screening in NewbornsNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT00004338
Study of Zinc for Wilson Diseasetreatment4completed
NCT01980433
Inhibitory rTMS in Dystonic Wilson PatientsNo drug interventionstreatmentNot Availablecompleted
NCT04965545
Role for Biochemical Assays and Kayser-Fleischer Rings in Diagnosis of Wilson DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT03403205
Efficacy and Safety of ALXN1840 Administered for 48 Weeks Versus Standard of Care in Participants With Wilson Diseasetreatment3terminated
NCT02426905
Study to Assess Long-Term Outcomes of Trientine in Wilson Disease Patients Withdrawn From Therapy With d-Penicillaminetreatment4unknown_status
NCT04526197
Phase 1 Study of ALXN1840 on the Metabolism of a CYP2C9 Substrate in Healthy Participants.treatment1completed
NCT05641311
Pharmacokinetic Study of Oral ALXN1840 in Japanese and Non-Japanese Adult Healthy ParticipantsNo drug interventionsbasic_science1completed
NCT04965571
Clinical Features and Outcome of Wilson's Disease With Generalized Epilepsy in Chinese PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT04573309
Copper and Molybdenum Balance in Participants With Wilson Disease Treated With ALXN1840No drug interventionstreatment2completed
NCT02763215
The Assessment of Copper Parameters in Wilson Disease Participants on Standard of Care TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT06430359
Circadian Variation of Urinary Copper Excretion in Wilson Disease PatientsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02273596
Efficacy and Safety Study of WTX101 (ALXN1840) in Adult Wilson Disease PatientsNo drug interventionstreatment2completed
NCT03867526
Establishment of Human Cellular Disease Models for Wilson DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT05687474
Baby Detect : Genomic Newborn ScreeningNo drug interventionsNot AvailableNot Availablerecruiting
NCT03659331
A Controlled Study of Potential Therapeutic Effect of Oral Zinc in Manifesting Carriers of Wilson DiseaseNo drug interventionstreatmentNot Availableunknown_status
NCT05231876
Wilson France RegisterNo drug interventionsNot AvailableNot Availablerecruiting
NCT06179394
Evaluation of Cognitive Dysfunction and Psychiatric ComorbiditiesNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06466291
Spanish Wilson Disease RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT04531189
Clinical Evaluation and Assessment of Instruments and Biomarkers in Subjects With Wilson DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT04909346
Adeno-Associated Virus (AAV) Antibody Study in Subjects OTC Deficiency, GSDIa, and Wilson DiseaseNo drug interventionsNot AvailableNot Availableterminated
NCT04526210
Study of ALXN1840 on the Metabolism of a CYP2B6 Substrate in Healthy Participantstreatment1completed
NCT05183165
Description of the Copper Concentration in Breast Milk in Women Treated for Wilson's DiseaseNo drug interventionsotherNot Availablerecruiting
NCT04537377
A Phase I/II Study of VTX-801 in Adult Patients With Wilson's DiseaseNo drug interventionstreatment1 / 2recruiting
NCT04012658
A Registered Cohort Study on Wilson's DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT02702765
sCD163 and sMR in Wilsons Disease - Associations With Disease Severity and FibrosisdiagnosticNot Availablecompleted
NCT03957720
The Individual Therapy for Patients With Wilson's Diseasetreatment0recruiting
NCT04212195
Cohort Research on Wilson's DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT00212355
Efficacy and Safety, Long-term Study of Zinc Acetate to Treat Wilson's Disease in Japan.No drug interventionstreatment3completed
NCT06128954
Study Comparing Once Daily Dose of 900mg of TETA 4HCL Against CupriorĀ® (450mg Trientine Base, Twice Daily).treatment1completed
NCT05493605
Cardiac Involvement in Wilson's DiseaseNo drug interventionsotherNot Availablerecruiting
NCT02552628
WILSTIM - DBS (WILson STIMulation - Deep Brain Stimulation)No drug interventionstreatmentNot Availablecompleted
NCT01874028
A Phase 1 Study to Assess the Effects in the Body of a Single Dose of Trientine Dihydrochloride in Wilson's Disease Patientstreatment1completed
NCT06051734
Early Detection of Cardiac Affection in Patients of Wilson's DiseaseNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05239858
International Wilson's Disease Patient Registry (iWilson Registry)No drug interventionsNot AvailableNot Availablerecruiting
NCT01378182
Efficacy of Invitro Expanded Bone Marrow Derived Allogeneic Mesenchymal Stem Cell Transplantation Via Portal Vein or Hepatic Artery or Peripheral Vein in Patients With Wilson CirrhosisNo drug interventionstreatmentNot Availablecompleted
NCT02252380
ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement DisordersNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT05305872
Gandouling in the Treatment of Wilson's Diseasetreatment4recruiting