This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Flurbiprofen axetil
DrugBank Accession Number
DB14938
Background

Flurbiprofen axetil is under investigation in clinical trial NCT02043366 (Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 330.355
Monoisotopic: 330.126737255
Chemical Formula
C19H19FO4
Synonyms
  • Flurbiprofen axetil

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe risk or severity of bleeding and hemorrhage can be increased when Flurbiprofen axetil is combined with Abciximab.
AcebutololFlurbiprofen axetil may decrease the antihypertensive activities of Acebutolol.
AceclofenacThe risk or severity of adverse effects can be increased when Aceclofenac is combined with Flurbiprofen axetil.
AcemetacinThe risk or severity of adverse effects can be increased when Acemetacin is combined with Flurbiprofen axetil.
AcenocoumarolThe risk or severity of bleeding and hemorrhage can be increased when Flurbiprofen axetil is combined with Acenocoumarol.
AcetaminophenThe risk or severity of adverse effects can be increased when Acetaminophen is combined with Flurbiprofen axetil.
AcetohexamideThe protein binding of Acetohexamide can be decreased when combined with Flurbiprofen axetil.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Flurbiprofen axetil.
AlclofenacThe risk or severity of adverse effects can be increased when Alclofenac is combined with Flurbiprofen axetil.
Alendronic acidThe risk or severity of adverse effects can be increased when Flurbiprofen axetil is combined with Alendronic acid.
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Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
I0OU31PUI5
CAS number
91503-79-6
InChI Key
ALIVXCSEERJYHU-UHFFFAOYSA-N
InChI
InChI=1S/C19H19FO4/c1-12(19(22)24-14(3)23-13(2)21)16-9-10-17(18(20)11-16)15-7-5-4-6-8-15/h4-12,14H,1-3H3
IUPAC Name
1-(acetyloxy)ethyl 2-{2-fluoro-[1,1'-biphenyl]-4-yl}propanoate
SMILES
CC(OC(C)=O)OC(=O)C(C)C1=CC(F)=C(C=C1)C1=CC=CC=C1

References

General References
Not Available
ChemSpider
3278
ChEBI
31627
ChEMBL
CHEMBL3183067

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionCatheter Related Bladder Discomfort1
4CompletedTreatmentPain1
4CompletedTreatmentPostoperative pain1
4TerminatedPreventionDelirium / Dexamethasone / Flubiprofen Axetil / Non-Small Cell Lung Carcinoma (NSCLC) / Surgery- Complications1
4TerminatedSupportive CareDexamethasone / Flubiprofen Axetil / Long-Term Effects Secondary to Cancer Therapy in Adults / Non-Small Cell Lung Carcinoma (NSCLC) / Surgery1
1RecruitingTreatmentFlurbiprofen Axetil / Perioperative Sleep Quality / Postoperative Inflammatory Markers / Postoperative pain / Preemptive Analgesia1
Not AvailableCompletedPreventionAnaesthesia therapy / Pain1
Not AvailableCompletedSupportive CareChronic Sinusitis / Surgery1
Not AvailableCompletedTreatmentAnaesthesia therapy / Pain / Surgery2
Not AvailableNot Yet RecruitingTreatmentFlurbiprofen Axetil / Postoperative pain / Postoperative Sleep Quality / Preemptive Analgesia / Sex Differences1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00186 mg/mLALOGPS
logP4.36ALOGPS
logP4.18ChemAxon
logS-5.2ALOGPS
pKa (Strongest Basic)-6.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area52.6 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity87.16 m3·mol-1ChemAxon
Polarizability34.15 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created at May 20, 2019 14:36 / Updated at February 21, 2021 18:55