Flurbiprofen axetil
Star0
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Flurbiprofen axetil
- DrugBank Accession Number
- DB14938
- Background
Flurbiprofen axetil is under investigation in clinical trial NCT02043366 (Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 330.355
Monoisotopic: 330.126737255 - Chemical Formula
- C19H19FO4
- Synonyms
- Flurbiprofen axetil
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab The risk or severity of bleeding and hemorrhage can be increased when Flurbiprofen axetil is combined with Abciximab. Acebutolol Flurbiprofen axetil may decrease the antihypertensive activities of Acebutolol. Aceclofenac The risk or severity of adverse effects can be increased when Aceclofenac is combined with Flurbiprofen axetil. Acemetacin The risk or severity of adverse effects can be increased when Acemetacin is combined with Flurbiprofen axetil. Acenocoumarol The risk or severity of bleeding and hemorrhage can be increased when Flurbiprofen axetil is combined with Acenocoumarol. - Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- I0OU31PUI5
- CAS number
- 91503-79-6
- InChI Key
- ALIVXCSEERJYHU-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H19FO4/c1-12(19(22)24-14(3)23-13(2)21)16-9-10-17(18(20)11-16)15-7-5-4-6-8-15/h4-12,14H,1-3H3
- IUPAC Name
- 1-(acetyloxy)ethyl 2-{2-fluoro-[1,1'-biphenyl]-4-yl}propanoate
- SMILES
- CC(OC(C)=O)OC(=O)C(C)C1=CC(F)=C(C=C1)C1=CC=CC=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 3278
- ChEBI
- 31627
- ChEMBL
- CHEMBL3183067
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Completed Prevention Anesthesia therapy / Pain 1 somestatus stop reason just information to hide Not Available Completed Supportive Care Chronic Sinusitis / Surgery 1 somestatus stop reason just information to hide Not Available Completed Treatment Anesthesia therapy / Pain / Surgery 2 somestatus stop reason just information to hide Not Available Unknown Status Supportive Care Anaplasia / Postoperative pain 1 somestatus stop reason just information to hide Not Available Unknown Status Treatment C.Delivery; Surgery (Previous), Gynecological 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00186 mg/mL ALOGPS logP 4.36 ALOGPS logP 4.18 Chemaxon logS -5.2 ALOGPS pKa (Strongest Basic) -6.8 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 52.6 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 87.16 m3·mol-1 Chemaxon Polarizability 34.15 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-00bc-2090000000-2be155d853da9799273f Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-06dm-6290000000-830ef8e95d18e9e05d29 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0a6r-9610000000-c848ee171f4a1907f94e Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-002b-0920000000-c9f4329126651aaa525d Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-00fu-3900000000-0281c8f57b5c363bab31 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-004j-2900000000-607a66ce543ce62e98bf Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 177.08641 predictedDeepCCS 1.0 (2019) [M+H]+ 179.44441 predictedDeepCCS 1.0 (2019) [M+Na]+ 186.71533 predictedDeepCCS 1.0 (2019)
Drug created at May 20, 2019 14:36 / Updated at February 21, 2021 18:55