Paroxysmal Nocturnal Haemoglobinuria (PNH)

Also known as: PNH - Paroxysmal Nocturnal Hemoglobinuria / Marchiafava-Micheli Syndrome / Paroxysmal Nocturnal Hemoglobinuria / Paroxysmal Nocturnal Hemoglobinuria (PNH) / Paroxysmal Nocturnal Haemoglobinuria / Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] / Haemoglobinuria: [external cause] or [haemolytic] or [paroxysmal nocturnal] / Paroxysmal nocturnal hemoglobinuria (disorder) / (Haemoglobinuria: [March]) or (Marchiafava-Micheli syndrome)

DrugDrug NameDrug Description
DB01257EculizumabA recombinant humanized monoclonal antibody used to reduce the risk of hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
DB16200IptacopanA factor B inhibitor used to treat paroxysmal nocturnal hemoglobinuria.
DB16694PegcetacoplanA complement inhibitor indicated in the treatment of adults with paroxysmal nocturnal hemoglobinuria.
DB11580RavulizumabA monoclonal antibody used to treat paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and myasthenia gravis.
DrugDrug NamePhaseStatusCount
DB18496BCX100131Recruiting1
DB11752Bryostatin 11Completed1
DB17722OMS9061Recruiting1
DB16694Pegcetacoplan1Completed2
DB00020Sargramostim1Completed1
DB17716Vensobafusp alfa1Completed1
DB16128Crovalimab1 / 2Active Not Recruiting1
DB00087Alemtuzumab2Completed2
DB00098Antithymocyte immunoglobulin (rabbit)2Completed1
DB00098Antithymocyte immunoglobulin (rabbit)2Recruiting1
DB16121Cemdisiran2Completed2
DB00531Cyclophosphamide2Active Not Recruiting1
DB00531Cyclophosphamide2Completed2
DB00531Cyclophosphamide2Recruiting1
DB00091Cyclosporine2Completed1
DB00091Cyclosporine2Unknown Status2
DB15401Danicopan2Completed3
DB01257Eculizumab2Active Not Recruiting1
DB01257Eculizumab2Completed3
DB01257Eculizumab2Not Yet Recruiting1
DB00099Filgrastim2Completed2
DB01073Fludarabine2Active Not Recruiting1
DB01073Fludarabine2Completed3
DB01073Fludarabine2Recruiting1
DB16200Iptacopan2Completed2
DB00848Levamisole2Unknown Status2
DB01042Melphalan2Completed2
DB16620Methopterin2Recruiting1
DB00563Methotrexate2Completed1
DB00563Methotrexate2Recruiting1
DB00075Muromonab2Completed1
DB00688Mycophenolate mofetil2Completed3
DB14991Nomacopan2Completed1
DB14991Nomacopan2Enrolling by Invitation1
DB17722OMS9062Recruiting1
DB16694Pegcetacoplan2Recruiting1
DB15218Pozelimab2Completed3
DB11580Ravulizumab2Active Not Recruiting1
DB11580Ravulizumab2Completed1
DB11580Ravulizumab2Recruiting1
DB00073Rituximab2Completed1
DB00864Tacrolimus2Completed1
DB00864Tacrolimus2Recruiting1
DB11926Tesidolumab2Completed1
DB04572Thiotepa2Completed1
DB11678Treosulfan2Recruiting1
DB18012Vemircopan2Active Not Recruiting1
DB17716Vensobafusp alfa2Recruiting1
DB15636Zilucoplan2Completed2
DB15636Zilucoplan2Terminated1
DB16121Cemdisiran3Recruiting2
DB16121Cemdisiran3Terminated1
DB16128Crovalimab3Active Not Recruiting2
DB16128Crovalimab3Recruiting1
DB15401Danicopan3Active Not Recruiting1
DB15401Danicopan3Completed1
DB01257Eculizumab3Active Not Recruiting2
DB01257Eculizumab3Completed11
DB01257Eculizumab3Recruiting2
DB01257Eculizumab3Terminated1
DB16200Iptacopan3Completed2
DB16200Iptacopan3Recruiting2
DB14991Nomacopan3Terminated1
DB16694Pegcetacoplan3Completed2
DB15218Pozelimab3Recruiting2
DB15218Pozelimab3Terminated2
DB11580Ravulizumab3Completed5
DB11580Ravulizumab3Recruiting1
DB11580Ravulizumab3Terminated1
DB01257Eculizumab4Completed1
DB11580Ravulizumab4Completed1
DB00877Sirolimus4Unknown Status1
DB00682Warfarin4Unknown Status1
DB09312Antilymphocyte immunoglobulin (horse)Not AvailableCompleted1
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableCompleted1
DB16121CemdisiranNot AvailableAvailable1
DB15401DanicopanNot AvailableAvailable1
DB01257EculizumabNot AvailableCompleted1
DB01073FludarabineNot AvailableCompleted1
DB16200IptacopanNot AvailableAvailable1
DB01042MelphalanNot AvailableCompleted1
DB16694PegcetacoplanNot AvailableNo Longer Available1
DB16694PegcetacoplanNot AvailableRecruiting1
DB15218PozelimabNot AvailableAvailable1
DB11580RavulizumabNot AvailableRecruiting1