Histone deacetylase 2

Details

Name
Histone deacetylase 2
Synonyms
  • 3.5.1.98
  • HD2
  • Protein deacylase HDAC2
Gene Name
HDAC2
UniProtKB Entry
Q92769Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0004647|Histone deacetylase 2
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
Number of residues
488
Molecular Weight
55363.855
Theoretical pI
5.75
GO Classification
Functions
chromatin binding / enzyme binding / histone deacetylase activity / NF-kappaB binding
Processes
behavioral response to ethanol / cardiac muscle hypertrophy / cellular response to dopamine / cellular response to heat / cellular response to hydrogen peroxide / cellular response to retinoic acid / cellular response to transforming growth factor beta stimulus / chromatin remodeling / circadian regulation of gene expression / dendrite development / embryonic digit morphogenesis / epidermal cell differentiation / eyelid development in camera-type eye / fungiform papilla formation / hair follicle placode formation / negative regulation of apoptotic process / negative regulation of dendritic spine development / negative regulation of MHC class II biosynthetic process / negative regulation of neuron projection development / negative regulation of peptidyl-lysine acetylation / odontogenesis of dentin-containing tooth / positive regulation of collagen biosynthetic process / positive regulation of epithelial to mesenchymal transition / positive regulation of interleukin-1 production / positive regulation of oligodendrocyte differentiation / positive regulation of proteolysis / positive regulation of tumor necrosis factor production / response to amphetamine / response to caffeine / response to cocaine / response to hyperoxia / response to lipopolysaccharide / response to nicotine
Components
cytoplasm / ESC/E(Z) complex / nucleoplasm / nucleus / NuRD complex
General Function
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674)
Specific Function
chromatin binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0016767|Histone deacetylase 2 (HDAC2)
ATGGCGTACAGTCAAGGAGGCGGCAAAAAAAAAGTCTGCTACTACTACGACGGTGATATT
GGAAATTATTATTATGGACAGGGTCATCCCATGAAGCCTCATAGAATCCGCATGACCCAT
AACTTGCTGTTAAATTATGGCTTATACAGAAAAATGGAAATATATAGGCCCCATAAAGCC
ACTGCCGAAGAAATGACAAAATATCACAGTGATGAGTATATCAAATTTCTACGGTCAATA
AGACCAGATAACATGTCTGAGTATAGTAAGCAGATGCAGAGATTTAATGTTGGAGAAGAT
TGTCCAGTGTTTGATGGACTCTTTGAGTTTTGTCAGCTCTCAACTGGCGGTTCAGTTGCT
GGAGCTGTGAAGTTAAACCGACAACAGACTGATATGGCTGTTAATTGGGCTGGAGGATTA
CATCATGCTAAGAAATCAGAAGCATCAGGATTCTGTTACGTTAATGATATTGTGCTTGCC
ATCCTTGAATTACTAAAGTATCATCAGAGAGTCTTATATATTGATATAGATATTCATCAT
GGTGATGGTGTTGAAGAAGCTTTTTATACAACAGATCGTGTAATGACGGTATCATTCCAT
AAATATGGGGAATACTTTCCTGGCACAGGAGACTTGAGGGATATTGGTGCTGGAAAAGGC
AAATACTATGCTGTCAATTTTCCAATGAGAGATGGTATAGATGATGAGTCATATGGGCAG
ATATTTAAGCCTATTATCTCAAAGGTGATGGAGATGTATCAACCTAGTGCTGTGGTATTA
CAGTGTGGTGCAGACTCATTATCTGGTGATAGACTGGGTTGTTTCAATCTAACAGTCAAA
GGTCATGCTAAATGTGTAGAAGTTGTAAAAACTTTTAACTTACCATTACTGATGCTTGGA
GGAGGTGGCTACACAATCCGTAATGTTGCTCGATGTTGGACATATGAGACTGCAGTTGCC
CTTGATTGTGAGATTCCCAATGAGTTGCCATATAATGATTACTTTGAGTATTTTGGACCA
GACTTCAAACTGCATATTAGTCCTTCAAACATGACAAACCAGAACACTCCAGAATATATG
GAAAAGATAAAACAGCGTTTGTTTGAAAATTTGCGCATGTTACCTCATGCACCTGGTGTC
CAGATGCAAGCTATTCCAGAAGATGCTGTTCATGAAGACAGTGGAGATGAAGATGGAGAA
GATCCAGACAAGAGAATTTCTATTCGAGCATCAGACAAGCGGATAGCTTGTGATGAAGAA
TTCTCAGATTCTGAGGATGAAGGAGAAGGAGGTCGAAGAAATGTGGCTGATCATAAGAAA
GGAGCAAAGAAAGCTAGAATTGAAGAAGATAAGAAAGAAACAGAGGACAAAAAAACAGAC
GTTAAGGAAGAAGATAAATCCAAGGACAACAGTGGTGAAAAAACAGATACCAAAGGAACC
AAATCAGAACAGCTCAGCAACCCCTGA
Chromosome Location
6
Locus
6q21
External Identifiers
ResourceLink
UniProtKB IDQ92769
UniProtKB Entry NameHDAC2_HUMAN
GenBank Protein ID1667394
GenBank Gene IDU31814
GeneCard IDHDAC2
GenAtlas IDHDAC2
HGNC IDHGNC:4853
PDB ID(s)3MAX, 4LXZ, 4LY1, 5IWG, 5IX0, 6G3O, 6WBW, 6WBZ, 6WHN, 6WHO, 6WHQ, 6WHZ, 6WI3, 6XDM, 6XEB, 6XEC, 7JS8, 7KBG, 7KBH, 7LTG, 7LTK, 7LTL, 7MOS, 7MOT, 7MOX, 7MOY, 7MOZ, 7ZZO, 7ZZP, 7ZZR, 7ZZS, 7ZZT, 7ZZU, 7ZZW, 8A0B, 8BPA, 8BPB, 8BPC, 8C60
KEGG IDhsa:3066
IUPHAR/Guide To Pharmacology ID2616
NCBI Gene ID3066
General References
  1. Yang WM, Inouye C, Zeng Y, Bearss D, Seto E: Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12845-50. [Article]
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Associated Data

Bio-Entities
Bio-EntityType
Histone deacetylase 2 (Humans)protein
primary
Histone deacetylase (Humans)protein
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Vorinostatapproved, investigationalyestargetinhibitorDetails
PracinostatinvestigationalunknowntargetDetails
MocetinostatinvestigationalunknowntargetDetails
Lovastatinapproved, investigationalnotargetinhibitorDetails
OxtriphyllineapprovedyestargetactivatorDetails
TheophyllineapprovedyestargetactivatorDetails
AminophyllineapprovedyestargetactivatorDetails
Valproic acidapproved, investigationalunknowntargetinhibitorDetails
Romidepsinapproved, investigationalyestargetantagonistinhibitorDetails
Tixocortolapproved, withdrawnyestargetstimulatorDetails
SimvastatinapprovedunknowntargetinhibitorDetails
PravastatinapprovedunknowntargetinhibitorDetails
FluvastatinapprovedunknowntargetinhibitorDetails
AtorvastatinapprovedunknowntargetinhibitorDetails
9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDEexperimentalyestargetinhibitorDetails
MartinostatinvestigationalyestargetinhibitorDetails
Belinostatapproved, investigationalyestargetinhibitorDetails
Panobinostatapproved, investigationalyestargetinhibitorDetails
Vorinostatapproved, investigationalunknowntargetinhibitorDetails
PyroxamideinvestigationalunknowntargetinhibitorDetails
Valproic acidapproved, investigationalunknowntargetinhibitorDetails
EntinostatinvestigationalyestargetinhibitorDetails
Phenylbutyric acidapproved, investigationalunknowntargetinhibitorDetails
Givinostatapproved, investigationalyestargetinhibitorDetails
Romidepsinapproved, investigationalunknowntargetinhibitorDetails
Decitabineapproved, investigationalunknowntargetinhibitorDetails
AbexinostatinvestigationalunknowntargetinhibitorDetails
Propanoic acidapproved, vet_approvedunknownenzymeinhibitorDetails