Search
Isocarboxazid Amine Oxidase Norepinephrine Antidepressant Action Pathway
smpdb.ca/view/SMP0126692Drug actionIsocarboxazid, also known as Marplan, is an antidepressant from the monoamine oxidase inhibitors (MAOIs) drug class. This drug is indicated in different disorders like major depression, dysthymic disorder, atypical disorder, panic disord...
Enzymes: Aromatic-L-amino-acid decarboxylasePhentermine Norepinephrine Reuptake transporter Satiety Action Pathway
smpdb.ca/view/SMP0126723Drug actionPhentermine is an amine anorectic agent used in weight reduction in cases of exogenous obesity as an adjunct or alone. It is chemically related to amphetamine. It is thought that the primary way phentermine works is by inducing a reducti...
Enzymes: Aromatic-L-amino-acid decarboxylaseDeficiency, Vitamin A
go.drugbank.com/conditions/DBCOND0085163Drugs: Ascorbic acid · Beta carotene · Cholecalciferol · Cod liver oil · Ergocalciferol · Vitamin A +1 moreDuloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway
smpdb.ca/view/SMP0126450Drug actionDuloxetine is a serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. It blocks both sodium dependent serotonin and sodium dependent norepinephr...
Enzymes: Aromatic-L-amino-acid decarboxylaseMethamphetamine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0125231Drug actionMethamphetamine (metamfetamine) is a psychostimulant and sympathomimetic drug. It is mainly taken recreationally but can be taken for ADHD and exogenous obesity in the form of a drug called Desoxyn. Methamphetamine induces effects of eup...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin +9 moreEnzymes: Aromatic-L-amino-acid decarboxylaseThe Oncogenic Action of Fumarate
smpdb.ca/view/SMP0002295DiseaseHaving a double bond in the centre of the dicarboxylic acid, fumarate is a rigid molecule compared to succinate making it a probable possibility for fumarate to interacts better with PHDs.
Phenylketonuria
smpdb.ca/view/SMP0125602DiseaseIt is also characterized by an accumulation of Phenylpyruvic acid, Mandelic acid, Phenylacetic acid, Phenylacetylglutamine, and Glycine in the blood and urine.
Drugs: Pyridoxal phosphate · Phenylalanine · L-Glutamine · Adenosine phosphate · Tyrosine · Glutamic acid +17 moreEnzymes: L-amino-acid oxidase, Y+L amino acid transporter 1Gemfibrozil Action Pathway
smpdb.ca/view/SMP0125290Drug actionFatty acid metabolism is also increased due to upregulation of acyl coA synthase, an enzyme involved in fatty acid oxidation. … This is because there is an upregulation of the fatty acid transporter. This decreases the amount of circulating fatty acids.
Enzymes: Retinoic acid receptor RXR-beta, Retinoic acid receptor RXR-alphaFenofibrate Action Pathway
smpdb.ca/view/SMP0125276Drug actionFatty acid metabolism is also increased due to upregulation of acyl coA synthase, an enzyme involved in fatty acid oxidation. … This is because there is an upregulation of the fatty acid transporter. This decreases the amount of circulating fatty acids.
Enzymes: Retinoic acid receptor RXR-beta, Retinoic acid receptor RXR-alphaBezafibrate Action Pathway (New)
smpdb.ca/view/SMP0125291Drug actionFatty acid metabolism is also increased due to upregulation of acyl coA synthase, an enzyme involved in fatty acid oxidation. … This is because there is an upregulation of the fatty acid transporter. This decreases the amount of circulating fatty acids.
Enzymes: Retinoic acid receptor RXR-beta, Retinoic acid receptor RXR-alpha