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Benzocaine Action Pathway
smpdb.ca/view/SMP0000392Drug actionBenzocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Benzocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonat...
Mepivacaine Action Pathway
smpdb.ca/view/SMP0000399Drug actionMepivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Mepivacaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is proton...
Prilocaine Action Pathway
smpdb.ca/view/SMP0000401Drug actionPrilocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Prilocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonat...
Ropivacaine Action Pathway
smpdb.ca/view/SMP0000404Drug actionRopivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Ropivacaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is proton...
Morphine Action Pathway
smpdb.ca/view/SMP0000406Drug actionMorphine exerts its analgesic by acting on the mu-opioid receptor of sensory neurons. Binding to the mu-opioid receptor activates associated G(i) proteins. These subsequently act to inhibit adenylate cyclase, reducing the level of intrac...
Heroin Action Pathway
smpdb.ca/view/SMP0000407Drug actionHeroin is a mu-opioid agonist. It acts on endogenous mu-opioid receptors that are spread in discrete packets throughout the brain, spinal cord and gut in almost all mammals. Heroin, along with other opioids, are agonists to four endogeno...
Oxycodone Action Pathway
smpdb.ca/view/SMP0000409Drug actionOxycodone (also known as OxyContin or Dihydrohydroxycodeinone) is analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of ...
Fentanyl Action Pathway
smpdb.ca/view/SMP0000415Drug actionCarfentanil (also known as Phentanyl or Fentora) is analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of intracellular ...
Disulfiram Action Pathway
smpdb.ca/view/SMP0000429Drug actionDisulfiram is a drug used in the treatment of cocaine addiction and chronic alcoholism. With regards to cocaine addiction, cocaine inhibits dopamine reuptake by blocking dopamine transporter 1 (DAT1). This increases dopamine concentratio...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Adenosine phosphate · Tyrosine +27 moreMethotrexate Action Pathway
smpdb.ca/view/SMP0000432Drug actionMethotrexate is an antifolate antimetabolite used in the treatment of rheumatoid arthritis and cancer. Methotrexate is taken up into the cell by human reduced folate carriers (SLC19A1). In the cytoplasm, methotrexate is polyglutamated by...