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Displaying results 141 - 150 of 359 in total
  1. Pathway

    Methadone Action Pathway

    smpdb.ca/view/SMP0000408
    Drug action

    Methadone exerts its analgesic by acting on the mu-opioid receptor of sensory neurons. Binding to the mu-opioid receptor activates associated G(i) proteins. These subsequently act to inhibit adenylate cyclase, reducing the level of intra...

    Drugs: NADH · ATP · Methadone · Norepinephrine · Dopamine · Potassium cation +3 more
  2. Pathway

    Caffeine Nervous Action Pathway

    smpdb.ca/view/SMP0125297
    Drug action

    In the locus coeruleus caffeine activates the release of norepinephrine through an unknown mechanism. … Norepinephrine accumulates in the synapse and activates Alpha-1 adrenergic receptors and beta-1 adrenrgic receptors.

    Drugs: Pyridoxal phosphate · Glutamic acid · Caffeine · Norepinephrine · Adenosine · Calcium +1 more
  3. Drug

    Nisoxetine

    go.drugbank.com/drugs/DB09186
    Experimental

    Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s.

    Categories: Norepinephrine, antagonists & inhibitors
  4. Pathway

    Morphine Action Pathway

    smpdb.ca/view/SMP0000406
    Drug action

    Morphine exerts its analgesic by acting on the mu-opioid receptor of sensory neurons. Binding to the mu-opioid receptor activates associated G(i) proteins. These subsequently act to inhibit adenylate cyclase, reducing the level of intrac...

    Drugs: ATP · Morphine · Norepinephrine · Dopamine · Potassium cation · Calcium +1 more
  5. Pathway

    Heroin Action Pathway

    smpdb.ca/view/SMP0000407
    Drug action

    Heroin is a mu-opioid agonist. It acts on endogenous mu-opioid receptors that are spread in discrete packets throughout the brain, spinal cord and gut in almost all mammals. Heroin, along with other opioids, are agonists to four endogeno...

    Drugs: ATP · Morphine · Norepinephrine · Dopamine · Potassium cation · Calcium +2 more
  6. Indication

    Shock

    go.drugbank.com/conditions/DBCOND0020137
    Drugs: Dextran · Norepinephrine · Plasma protein fraction (human)
  7. Drug

    Metamfetamine

    go.drugbank.com/drugs/DB01577
    ApprovedIllicitInvestigationalWithdrawn

    Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enha...

  8. Pathway

    Fluoxetine Action Pathway

    smpdb.ca/view/SMP0000426
    Drug action

    Fluoxetine is a selective serotonin reuptake inhibitor that exerts antidepressive effects by selectively inhibiting serotonin reuptake in the brain. It does so by competing for the same binding site as serotonin on the the sodium-depende...

    Drugs: NADH · ATP · Norepinephrine · Fluoxetine · Dopamine · Potassium cation +4 more
  9. Drug

    Queuine

    go.drugbank.com/drugs/DB14732
    ExperimentalNutraceutical

    Endogenously, it has been determined that queuine contributes to generating various important biochemicals like tyrosine, serotonin, dopamine, epinephrine, norepinephrine, nitric oxide, lipids, and others

  10. Pathway

    Catecholamine Biosynthesis

    smpdb.ca/view/SMP0000012
    Metabolic

    The commonly found catecholamines are epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. … The L-DOPA is then converted to dopamine via aromatic L-amino acid decarboxylase (AADC), which becomes norepinephrine via dopamine beta-hydroxylase (DBH); and finally is converted to epinephrine via phenylethanolamine

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 more