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Streptomycin Tuberculosis Action Pathway
smpdb.ca/view/SMP0718084Drug actionThis pathway illustrates the multifaceted interactions between streptomycin—an aminoglycoside antibiotic—and Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), highlighting its antibacterial mechanism, molecular targets, and downstr...
Phospholipid Biosynthesis
smpdb.ca/view/SMP0000025MetabolicThis pathway describes the synthesis of the common phospholipids, including phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol and cardiolipins. Phospholipid synthesis is mediated by two possible mech...
Drugs: Choline · Phosphatidyl serine · NADH · Calcium · Magnesium cation · sn-glycerol 3-phosphate +5 moreCaffeine Metabolism
smpdb.ca/view/SMP0000028MetabolicCaffeine is obtained from diet including coffee and other beverages and is absorbed in the stomach and small intestine. In the liver, the cytochrome P450 oxidase enzyme system and specifically CYP1A2 metabolizes caffeine into paraxanthin...
Drugs: NADH · Caffeine · Theophylline · Theobromine · Mesoheme · Flavin adenine dinucleotide +1 moreNicotinate and Nicotinamide Metabolism
smpdb.ca/view/SMP0000048MetabolicNicotinate (niacin) and nicotinamide - more commonly known as vitamin B3 - are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). NAD+ synthesis occurs either de ...
Purine Metabolism
smpdb.ca/view/SMP0000050MetabolicPurine is a water soluble, organic compound. Purines, including purines that have been substituted, are the most widely distributed kind of nitrogen-containing heterocycle in nature. The two most important purines are adenine and guanine...
Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +24 moreFatty Acid Metabolism
smpdb.ca/view/SMP0000051MetabolicFatty acids constitute a large energy source for the body. The cellular membrane is also made up of fatty acids. During starvation times, fatty acids can provide energy to humans for numerous days. Fatty acid metabolism is also known as ...
Drugs: Adenosine phosphate · NADH · ATP · Levocarnitine · Magnesium cation · Flavin adenine dinucleotide +2 morePyruvate Metabolism
smpdb.ca/view/SMP0000060MetabolicPyruvate is an intermediate compound in the metabolism of fats, proteins, and carbohydrates. It can be formed from glucose via glycolysis or the transamination of alanine. It can be converted into Acetyl-CoA to be used as the primary ene...
Tryptophan Metabolism
smpdb.ca/view/SMP0000063MetabolicThis pathway depicts the metabolic reactions and pathways associated with tryptophan metabolism in animals. Tryptophan is an essential amino acid. This means that it cannot be synthesized by humans and other mammals and therefore must be...
Drugs: Pyridoxal phosphate · Ademetionine · Adenosine phosphate · Glutamic acid · Tryptophan · NADH +18 moreAspartate Metabolism
smpdb.ca/view/SMP0000067MetabolicAspartate is synthesized by transamination of oxaloacetate by aspartate aminotransferase or amino acid oxidase. Aspartyl-tRNA synthetase can then couple aspartate to aspartyl tRNA for protein synthesis. The aspartate content in human pro...
Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +13 moreButyrate Metabolism
smpdb.ca/view/SMP0000073MetabolicButyrate metabolism (Butanoate metabolism) describes the metabolic fate of a number of short chain fatty acids or short chain alcohols that are typically produced by intestinal fermentation. Many of these molecules are eventually used in...
Drugs: Adenosine phosphate · Succinic acid · NADH · ATP · Magnesium cation · Acetoacetic acid +3 more