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Pramipexole Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126459Drug actionPramipexole is indicated for the management of Parkinson's disease and symptomatic treatment of moderate to severe primary Restless Legs Syndrome (RLS). Pramipexole likely restores balance to the dopaminergic system, controlling the symp...
Enzymes: Sodium-dependent dopamine transporterNeuronal Dopamine Gs Cascade
smpdb.ca/view/SMP0126952PhysiologicalActions of the neurotransmitter dopamine in the brain are mediated by dopamine receptors that belong to the superfamily of G protein-coupled receptors (GPCRs). Mammals have five dopamine receptor subtypes, D1 through D5. D1 and D5 couple...
Enzymes: Sodium-dependent dopamine transporterDomperidone Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126605Drug actionDomperidone is known as a prokinetic dopamine antagonist. It acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor ...
Enzymes: Sodium-dependent dopamine transporterGuanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)
smpdb.ca/view/SMP0125628DiseaseTreatment includes arginine-restricted diet, sodium benzoate, and L-ornithine hydrochlorate.
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 morePamidronate Action Pathway
smpdb.ca/view/SMP0000117Drug actionIbandronate (also named ibandronate sodium) is a type of medication that used to treat numbers of bone diseases because of its affinity for hydroxyapatite.
Drugs: Cholecalciferol · ATP · Pamidronic acid · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 moreGuanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)
smpdb.ca/view/SMP0000188DiseaseTreatment includes arginine-restricted diet, sodium benzoate, and L-ornithine hydrochlorate.
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 moreOxidation of Branched-Chain Fatty Acids
smpdb.ca/view/SMP0000030MetabolicIn the majority of organisms, fatty acid degradation occurs mostly through the beta-oxidation cycle. In plants, this cycle only happens in the peroxisome, while in mammals this cycle happens in both the peroxisomes and mitochondria. Unfo...
Nicotinate and Nicotinamide Metabolism
smpdb.ca/view/SMP0000048MetabolicNicotinate (niacin) and nicotinamide - more commonly known as vitamin B3 - are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). NAD+ synthesis occurs either de ...
Retinol Metabolism
smpdb.ca/view/SMP0000074MetabolicRetinol is part of the vitamin A family, and is known as vitamin A1, and in a dietary context it is a type of preformed vitamin A. As with other preformed vitamin A's, it can be obtained from animal sources, with the highest concentratio...
Ibandronate Action Pathway
smpdb.ca/view/SMP0000079Drug actionThe action of ibandronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and...
Drugs: Cholecalciferol · ATP · Ibandronate · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 more