Search
Nilotinib Inhibition of BCR-ABL Action Pathway
smpdb.ca/view/SMP0031697Drug actionNilotinib is a tyrosine kinase inhibitor used to treat chronic myelogenous leukemia (CML), a cancer characterized by increased and unregulated growth of white blood cells in the bone marrow and the accumulation of these cells in the bloo...
Drugs: NilotinibEnzymes: S-phase kinase-associated protein 2Asciminib Inhibition of BCR-ABL
smpdb.ca/view/SMP0126943Drug actionAsciminib is an inhibitor of ABL/BCR-ABL1 tyrosine kinase for the treatment of patients with Philadelphia chromosome-positive CML, including those with the T315I mutation. Asciminib is an allosteric inhibitor of the BCR-ABL1 tyrosine kin...
Drugs: AsciminibEnzymes: S-phase kinase-associated protein 2Escitalopram Mechanism of Action Action Pathway New
smpdb.ca/view/SMP0126509Drug actionEscitalopram is the therapeutic active S- enantiomer of citalopram. It is classified as a selective serotonin reuptake inhibitor used to treat depression and anxiety.
Molybdenum Cofactor Deficiency
smpdb.ca/view/SMP0000203DiseaseDefects in this enzyme cause accumulation of hypoxanthine,, s-s-sulfocysteine, taurine, and xanthine in the urine.
Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +24 moreMolybdenum Cofactor Deficiency
smpdb.ca/view/SMP0125725DiseaseDefects in this enzyme cause accumulation of hypoxanthine,, s-s-sulfocysteine, taurine, and xanthine in the urine.
Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +24 moreDasatinib Inhibition of BCR-ABL Action Pathway
smpdb.ca/view/SMP0031696Drug actionDasatinib is a tyrosine kinase inhibitor used to treat chronic myelogenous leukemia (CML), a cancer characterized by increased and unregulated growth of white blood cells in the bone marrow and the accumulation of these cells in the bloo...
Drugs: DasatinibEnzymes: S-phase kinase-associated protein 2Bafetinib Inhibition of BCR-ABL Action Pathway
smpdb.ca/view/SMP0031699Drug actionBafetinib is a tyrosine kinase inhibitor used to treat chronic myelogenous leukemia (CML), a cancer characterized by increased and unregulated growth of white blood cells in the bone marrow and the accumulation of these cells in the bloo...
Drugs: BafetinibEnzymes: S-phase kinase-associated protein 23-Hydroxyisobutyric Acid Dehydrogenase Deficiency
smpdb.ca/view/SMP0000521DiseaseOther forms of 3-hydroxyisobutyric aciduria may be caused by a mutation in the gene encoding 3-hydroxyisobutyrate dehydrogenase, which forms (S)-methylmalonic acid semialdehyde from (S)-3-hydroxyisobutyric … This mutation leads to an accumulation of (S)-3-hydroxyisobutyric acid, as no other processes in the pathway use it. 3-hydroxyisobutyric aciduria is characterized by elevated levels of 3-hydroxyisobutyric
Aromatic L-Aminoacid Decarboxylase Deficiency
smpdb.ca/view/SMP0000170DiseaseIt also results in decreased concentrations of homovanillic acid, S-adenosylmethionine, and 5-hydroxytryptophol in spinal fluid; and epinephrine, norepinephrine in plasma.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 moreAromatic L-Aminoacid Decarboxylase Deficiency
smpdb.ca/view/SMP0125610DiseaseIt also results in decreased concentrations of homovanillic acid, S-adenosylmethionine, and 5-hydroxytryptophol in spinal fluid; and epinephrine, norepinephrine in plasma.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 more