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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb.ca/view/SMP0000320SignalingThe A2A receptor is responsible for regulating myocardial blood flow by vasodilating the coronary arteries, which increases blood flow to the myocardium, but may lead to hypotension. The A2A receptor is also expressed in the brain, where...
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acidMercaptopurine Action Pathway (New)
smpdb.ca/view/SMP0126475Drug actionMercaptopurine is an antimetabolic antineoplastic agent used in the treatment and maintenance therapy of acute lymphatic leukemia (ALL), acute promyelocytic leukemia, autoimmune hepatitis, Crohn's disease (CD), lymphoblastic lymphoma, an...
Drugs: Tetrahydrofolic acid · Ademetionine · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +12 moreDipyridamole Action Pathway
smpdb.ca/view/SMP0122804Drug actionDipyridamole is an oral coronary vasodilator and antiplatelet drug used in combination with other anti-coagulant drugs to prevent thrombosis in patients with valvular and vascular disorders. Dipyridamole works through many mechanisms inc...
Dipyridamole Phosphodiesterase Action Pathway
smpdb.ca/view/SMP0126489Drug actionDipyridamole is a phosphodiesterase inhibitor also known as Aggrenox and Persantine, used to prevent thromboembolic events post-operation. Routes of administration fall under intravenous or oral administration. Dipyridamole inhibits aden...
Azathioprine Action Pathway (New)
smpdb.ca/view/SMP0126488Drug actionAzathioprine is an immunosuppressor prodrug. It is used to treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis. Also, azathioprine is used in the prevention of renal transplant rejection. This molecule is the prodrug of 6...
Drugs: Tetrahydrofolic acid · Ademetionine · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +13 moreFungal Infections
go.drugbank.com/conditions/DBCOND0032278Drugs: Amphotericin B · Benzoic acid · Bifonazole · Caspofungin · Fenticonazole · Fluconazole +8 moreSalicylate-Sodium Action Pathway
smpdb.ca/view/SMP0000708Drug actionSalicylate-sodium (also named salsonin or clin) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used for relieving pain and reducing fever. Salicylate-sodium can block prostaglandin synthesis by the action of inhibition of pr...
Drugs: Glutamic acid · Glutathione · Dinoprostone · Calcium · Magnesium cation · Salicylic acid +5 moreSalicylic Acid Action Pathway
smpdb.ca/view/SMP0000709Drug actionSalicylic acid (also named rutranex or salonil) is a nonsteroidal anti-inflammatory drug. Salicylic acid is also an important active metabolite of aspirin (acetylsalicylic acid). It can be used to reduce pain and fever. Salicylic acid ca...
Drugs: Glutamic acid · Glutathione · Dinoprostone · Salicylic acid · Calcium · Magnesium cation +5 moreEthanol GABA Agonist Action Pathway
smpdb.ca/view/SMP0125151Drug actionEthanol, commonly seen in the form of various alcohols as well as hand sanitizer, is a drug that is injected intrathecally. Ethanol's effects are mainly seen in the brain where it binds to many receptors. The main effects are seen by the...
S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
smpdb.ca/view/SMP0000214DiseaseS-Adenosylhomocysteine hydrolase deficiency, also known as AdoHcy hydrolase deficiency or adenosylhomocysteinase (AHCY) deficiency, is an autosomal recessive disorder characterized by a defective AHCY gene. AHCY codes for the enzyme S-ad...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more