Search
Acetaminophen Metabolism Pathway
smpdb.ca/view/SMP0000640Drug metabolismAcetaminophen (APAP) is metabolized primarily in the liver. Glucuronidation is the main route, accounting for 45-55% of APAP metabolism, and is mediatied by UGT1A1, UGT1A6, UGT1A9, UGT2B15 in the liver and UGT1A10 in the gut. APAP can al...
Naltrexone Action Pathway
smpdb.ca/view/SMP0000687Drug actionNaltrexone is also a type of medication that are used for manage opioid or alcohol dependence.
Isoprenaline B1-Adrenergic Cardiac Muscle Contraction Action Pathway
smpdb.ca/view/SMP0122740Drug actionIsoprenaline (also called isoproterenol) is a non-selective beta-adrenergic agonist. It is administered via IV or oral inhalation and is used to treat conditions including mild or transient episodes of heart block that do not require pac...
Acetaminophen Action Pathway (New)
smpdb.ca/view/SMP0122823Drug actionAcetaminophen is an oral/IV antipyretic and analgesic drug used to treat fevers and mild to moderate pain. Its exact mechanism is unknown but it is thought to target the cyclooxygenase pathway in the CNS (brain). It does not inhibit the ...
Metabolism and Physiological Effects of Phenyl glucuronide
smpdb.ca/view/SMP0123227MetabolicPhenyl glucuronide is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a glucuronidation reaction in liver hepatic cells. After being transported into gut microbes, tyrosine undergoes a reacti...
Epinephrine B2-Adrenergic Bronchodilation Action Pathway
smpdb.ca/view/SMP0124452Drug actionEpinephrine is a non-selective adrenergic receptor agonist drug used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. It is usually administered intravenously. It targets th...
Docetaxel Action Pathway (New)
smpdb.ca/view/SMP0124488Drug actionDocetaxel is a taxane/taxoid antineoplastic agent used to treat ovarian and breast cancer. In comparison to paclitaxel, docetaxel has a higher binding affinity for tubulin, specifically the beta subunit. Docetaxel binds to tubulin dimers...
Drugs: DocetaxelNaltrexone Opioid Antagonist Action Pathway
smpdb.ca/view/SMP0125274Drug actionIt is also used to treat alcohol dependence in conjunction with behavioural programs.
Drugs: ATP · Naltrexone · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +1 moreLevallorphan Action Pathway (New)
smpdb.ca/view/SMP0125336Drug actionHowever, Levallorphan has been found to increase respiratory depression caused by alcohol or other drugs.
Drugs: ATP · Levallorphan · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acidImmunometabolism Pathway (Bacterial Activation)
smpdb.ca/view/SMP0125484DiseaseThe normal response to a bacterial infection involves bacteria activateing the Toll-like receptor TLR4 on the membranes of macrophages, T-cells and dendritic cells. TLR4 activates the production of interferon regulatory factor 3 (IRF3), ...