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Sarcosinemia
smpdb.ca/view/SMP0000244DiseaseSarcosine can also be formed in a reversible reaction from S-adenosylmethionine and glycine, using glycine N-methyltransferase as the enzyme, and forming S-adenosylhomocysteine as another product. … This, along with homocysteine, react using betaine-homocysteine S-methyltransferase to form L-methionine, as well as dimethylglycine.
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreEnzymes: Betaine--homocysteine S-methyltransferase 1Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway
smpdb.ca/view/SMP0126647Drug actionBy antagonizing the beta-1 adrenergic receptor and blocking G(s) signalling, smooth muscle constriction of the ciliary muscles of the eye make it more difficult for the aqueous humour to reach the eye.
Drugs: ATP · Carteolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphateEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Alprostadil Action Pathway
smpdb.ca/view/SMP0127008Drug actionAlprostadil is a medication used for two distinct purposes. First, it is employed in the treatment of erectile dysfunction in men for whom oral treatment is either contraindicated or ineffective. It can be administered either through an ...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Iloprost Action Pathway
smpdb.ca/view/SMP0126507Drug actionIloprost is a prostacyclin analog also known as Ventavis, that acts to prevent platelet aggregation. It is a second-generation analog that is structurally similar to prostacyclin. It binds to prostacyclin receptors that activate adenylyl...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Sarcosinemia
smpdb.ca/view/SMP0125579DiseaseSarcosine can also be formed in a reversible reaction from S-adenosylmethionine and glycine, using glycine N-methyltransferase as the enzyme, and forming S-adenosylhomocysteine as another product. … This, along with homocysteine, react using betaine-homocysteine S-methyltransferase to form L-methionine, as well as dimethylglycine.
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreEnzymes: Betaine--homocysteine S-methyltransferase 1Bimatoprost Action Pathway
smpdb.ca/view/SMP0127009Drug actionBimatoprost is a prostaglandin analog with multiple medical applications. It belongs to the prostamide group of drugs and is available in both ophthalmic solution and implant forms. Primarily, bimatoprost is used to manage elevated intra...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Timolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway
smpdb.ca/view/SMP0126232Drug actionTimolol is a non-selective beta-adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma. Timolol competes with adrenergic neurotransmitters for binding to beta(1)-adrenergic...
Drugs: ATP · Timolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphateEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Epoprostenol Action Pathway
smpdb.ca/view/SMP0126492Drug actionEpoprostenol is a platelet aggregator inhibitor also known under the brand name of Flolan and Veletri, used to manage hypertension in patients with heart failure. It is synthesized from prostaglandin endoperoxides in human vascular tissu...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Selenoamino Acid Metabolism
smpdb.ca/view/SMP0000029MetabolicPhospholipids are membrane components in P. aeruginosa. The major phospholipids of P. aeruginosa are phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. All phospholipids contain sn-glycerol-3-phosphate esterified with fatty...
Enzymes: S-adenosylmethionine synthase isoform type-2Lafutidine H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0051038Drug actionLafutidine (also known as INN) is a second generation histamine H2 receptor antagonist that can be used for treating ulcers and reflux. Inhibition of histamine H2 receptor can inhibit histamine-stimulated gastric acid secretion which wil...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short