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Methylphosphinic Acid Action Pathway
smpdb.ca/view/SMP0126733Drug actionMethylphosphinic acid is an experimental drug being tested to be a possible cholinesterase inhibitor, as it appears to inhibit the breakdown of acetylcholine. … Further research needs to be conducted in order to confirm results, safety and confirm the mechanism of action.
Oxidronic acid Drug Metabolism
smpdb.ca/view/SMP0130675MetabolicOxidronic acid passes through the liver and is then excreted from the body mainly through the kidney. … Oxidronic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Oxidronic acidEthacrynic Acid Diuretic Action Pathway
smpdb.ca/view/SMP0124515Drug actionEthacrynic acid binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen. … This is relieves symptoms such as swelling/ edema and hypertension in patients. Ethacrynic acid may also inhibit sodium and chloride reabsorption in the proximal and distal tubules.
3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
smpdb.ca/view/SMP0125673Diseaseacid. … acid excreted in the urine.
Enzymes: Branched-chain-amino-acid aminotransferase, cytosolic, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrialTiaprofenic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174732MetabolicMetabolites of Tiaprofenic acid are predicted with biotransformer.
Tolfenamic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174765MetabolicMetabolites of Tolfenamic acid are predicted with biotransformer.
Phenylalanine and Tyrosine Metabolism
smpdb.ca/view/SMP0000008MetabolicFumarylacetoacetate is finally split via fumarylacetoacetate-hydrolase into fumarate (also a metabolite of the citric acid cycle) and acetoacetate (3-ketobutyroate). … This reaction functions both as the first step in tyrosine/phenylalanine catabolism by which the body disposes of excess phenylalanine, and as a source of the amino acid tyrosine.
Drugs: Pyridoxal phosphate · Phenylalanine · Adenosine phosphate · Tyrosine · Glutamic acid · ATP +11 moreEnzymes: L-amino-acid oxidaseArginine and Proline Metabolism
smpdb.ca/view/SMP0000020MetabolicIn particular, the amino acid citrulline is first synthesized from several other amino acids (glutamine, glutamate, and proline) in the mitochondria of the intestinal enterocytes (PMID: 9806879). … The arginine and proline metabolism pathway illustrates the biosynthesis and metabolism of several amino acids including arginine, ornithine, proline, citrulline, and glutamate in mammals.
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 moreEnzymes: D-amino-acid oxidaseMetabolism and Physiological Effects of N-Acetyl-1-Methylhistidine
smpdb.ca/view/SMP0126802MetabolicHigher circulating levels of five of these N-acetylated amino acids, namely, N-δ-acetylornithine, N-acetyl-1-methylhistidine, N-acetyl-3-methylhistidine, N-acetylhistidine, and N2,N5-diacetylornithine, … N-Acetyl-1-methylhistidine belongs to the class of organic compounds known as histidine and derivatives.
Enzymes: Actin-histidine N-methyltransferaseMetabolism and Physiological Effects of N-Acetyl-L-Alanine
smpdb.ca/view/SMP0126554MetabolicN-Acetyl-L-alanine can also be classified as an alpha amino acid or a derivatized alpha amino acid. … N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom.
Drugs: Alanine