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Catecholamine Biosynthesis
smpdb.ca/view/SMP0000012MetabolicThe Catecholamine Biosynthesis pathway depicts the synthesis of catecholamine neurotransmitters. Catecholamines are chemical hormones released from the adrenal glands as a response to stress that activate the sympathetic nervous system. ...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 moreSphingolipid Metabolism
smpdb.ca/view/SMP0000034MetabolicThe core of a sphingolipid is the long-chain amino alcohol called sphingosine. Amino acylation, with a long-chain fatty acid, at the 2-carbon position of sphingosine yields a ceramide.
Aromatic L-Aminoacid Decarboxylase Deficiency
smpdb.ca/view/SMP0000170DiseaseAromatic L-Aminoacid Decarboxylase Deficiency (DOPA decarboxylase; DDC) is an autosomal recessive disease caused by a mutation in the DDC gene which codes for aromatic-L-aminoacid decarboxylase. A deficiency in this enzyme results in acc...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 morePyruvate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0000212DiseasePyruvate dehydrogenase complex deficiency results from a mutation in the E1-alpha polypeptide gene (PDHA1). PDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA fo...
Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
smpdb.ca/view/SMP0000334DiseasePyruvate Decarboxylase E1 Component Deficiency is caused by a defect in the PDHA1 gene which codes for mitochondrial pyruvate dehydrogenase E1 component subunit alpha, somatic form. This is a homotetrameric enzyme that catalyses the deca...
Labetalol Action Pathway
smpdb.ca/view/SMP0000368Drug actionLabetalol (also known as Albetol or Ibidomide) is an inhibitor/antagonist of beta-1 adrenergic receptor that can be used for treating high blood pressure and reducing cardiac output. Labetalol can bind to beta-1 adrenergic receptor on bo...
Lidocaine (Local Anaesthetic) Action Pathway
smpdb.ca/view/SMP0000398Drug actionLidocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Lidocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated...
Tyrosine Hydroxylase Deficiency
smpdb.ca/view/SMP0000497DiseaseTyrosine Hydroxylase (TH) Deficiency is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of catecholamines pathways. The disorder is caused by defects in the Tyrosine hydroxylase (TH) gene which encodes for the en...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 moreEpinephrine Action Pathway
smpdb.ca/view/SMP0000661Drug actionEpinephrine can be derived from phenylalanine and tyrosine and it is an active sympathomimetic hormone that can be secreted from adrenal medulla. Epinephrine can stimulate alpha- and beta- adrenergic systems by binding on alpha-1 and bet...
Isoprenaline Action Pathway
smpdb.ca/view/SMP0000663Drug actionIsoprenaline (also known as isoproterenol) is a selective beta adrenergic bronchodilator that can be used for treating slow heart rate (bradycardia), heart block, and rarely for asthma. Isoprenaline can bind and inhibit beta-1 adrenergic...