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Metabolism and Physiological Effects of Uric acid
smpdb.ca/view/SMP0124845MetabolicAdenosine then reacts with water to form inosine and ammonia using the enzyme adenosine deaminase. Inosine goes on to form hypoxanthine through the enzyme purine nucleoside phosphorylase. … Uric acid can enter the blood and produce toxic effects on the cardiovascular, renal and joints, leading to cardiovascular disease, kidney disease and arthritis/ gout.
Metabolism and Physiological Effects of Oxalic acid
smpdb.ca/view/SMP0124875MetabolicGlyoxylate is generated through glycine and hydroxyproline catabolism and can be converted to oxalate. In humans, this process takes place in the liver. … Glycine and hydroxyproline comes from protein sources in the diet such as red meat and eggs. Glycine Is converted into glyoxylate in the peroxisome by the enzyme d-amino acid oxidase.
Drugs: Pyridoxal phosphate · Ascorbic acid · Succinic acid · Glutamic acid · Glycine · Proline +4 moreEnzymes: Sodium- and chloride-dependent transporter XTRP3, Sodium- and chloride-dependent creatine transporter 1Metabolsim and Physiological Effects of Argininic acid
smpdb.ca/view/SMP0125504MetabolicArginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … Argininic acid is a uremic toxin that is toxic to the nervous system, and it causes various neurlogical disorders such as variable degree of mental retardation, epilepsy and progressive spasticity.
Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 moreMetabolism and Physiological Effects of 3-Deoxyglucosone
smpdb.ca/view/SMP0125516MetabolicAn amino acid like arginine or lysine are combined with glucose to make a schiff base and water. The schiff base is unstable so it becomes the stable amadori product. … It normally is synthesized and accumulates with high serum glucose due to diabetes. 3-deoxyglucosone causes cell apoptosis and neurotoxicity.
Metabolism and Physiological Effects of N-Acetylproline
smpdb.ca/view/SMP0126660MetabolicAbout 85% of all human proteins and 68% of all yeast proteins are acetylated at their N-terminus. … N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins.
Metabolism and Physiological Effects of N-Acetylvaline
smpdb.ca/view/SMP0126701MetabolicThe human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G). … N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins.
Drugs: ValineMetabolism and Physiological Effects of N-Acetylmethionine
smpdb.ca/view/SMP0126707MetabolicAbout 85% of all human proteins and 68% of all yeast proteins are acetylated at their N-terminus. … The human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G).
Metabolism and Physiological Effects of N-Acetylhistidine
smpdb.ca/view/SMP0126711MetabolicThe human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G). … N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins.
Drugs: HistidineMetabolism and Physiological Effects of Beta-Alanine
smpdb.ca/view/SMP0126732MetabolicIt is a component of the naturally occurring peptides carnosine and anserine and also of pantothenic acid (vitamin B-5), which itself is a component of coenzyme A. … It is formed in vivo by the degradation of dihydrouracil and carnosine.
Metabolism and Physiological Effects of Indolelactic Acid
smpdb.ca/view/SMP0126749MetabolicIndolelactic acid (CAS: 1821-52-9) is a tryptophan metabolite found in human plasma, serum, and urine. … Tryptophan is metabolized by two major pathways in humans, either through kynurenine or via a series of indoles, and some of its metabolites are known to be biologically active.