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Oxidronic acid Drug Metabolism
smpdb.ca/view/SMP0130675MetabolicOxidronic acid passes through the liver and is then excreted from the body mainly through the kidney. … Oxidronic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Oxidronic acidEthacrynic Acid Diuretic Action Pathway
smpdb.ca/view/SMP0124515Drug actionEthacrynic acid binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen. … This is relieves symptoms such as swelling/ edema and hypertension in patients. Ethacrynic acid may also inhibit sodium and chloride reabsorption in the proximal and distal tubules.
3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
smpdb.ca/view/SMP0125673Diseaseacid. … 3-Hydroxyisobutyric acid dehydrogenase deficiency (3-hydroxyisobutyric aciduria) is an extremely rare inborn error of metabolism (IEM), potentially caused by numerous mechanisms.
Enzymes: Branched-chain-amino-acid aminotransferase, cytosolic, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrialTiaprofenic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174732MetabolicMetabolites of Tiaprofenic acid are predicted with biotransformer.
Tolfenamic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174765MetabolicMetabolites of Tolfenamic acid are predicted with biotransformer.
Phenylalanine and Tyrosine Metabolism
smpdb.ca/view/SMP0000008MetabolicFumarylacetoacetate is finally split via fumarylacetoacetate-hydrolase into fumarate (also a metabolite of the citric acid cycle) and acetoacetate (3-ketobutyroate). … This reaction functions both as the first step in tyrosine/phenylalanine catabolism by which the body disposes of excess phenylalanine, and as a source of the amino acid tyrosine.
Drugs: Pyridoxal phosphate · Phenylalanine · Adenosine phosphate · Tyrosine · Glutamic acid · ATP +11 moreEnzymes: L-amino-acid oxidaseArginine and Proline Metabolism
smpdb.ca/view/SMP0000020MetabolicIn particular, the amino acid citrulline is first synthesized from several other amino acids (glutamine, glutamate, and proline) in the mitochondria of the intestinal enterocytes (PMID: 9806879). … The arginine and proline metabolism pathway illustrates the biosynthesis and metabolism of several amino acids including arginine, ornithine, proline, citrulline, and glutamate in mammals.
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 moreEnzymes: D-amino-acid oxidaseValine, Leucine, and Isoleucine Degradation
smpdb.ca/view/SMP0000032MetabolicAs a result, three different α-keto acids are produced and are oxidized using a common branched-chain α-keto acid dehydrogenase (BCKD), yielding the three different CoA derivatives. … Valine, isoleuciine, and leucine are essential amino acids and are identified as the branched-chain amino acids (BCAAs).
Enzymes: Branched-chain-amino-acid aminotransferase, cytosolic, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrialThreonine and 2-Oxobutanoate Degradation
smpdb.ca/view/SMP0000452Metabolic2-oxobutanoate, also known as 2-Ketobutyric acid, is a 2-keto acid that is commonly produced in the metabolism of amino acids such as methionine and threonine. … Like other 2-keto acids, degradation of 2-oxobutanoate occurs in the mitochondrial matrix and begins with oxidative decarboxylation to its acyl coenzyme A derivative, propionyl-CoA.
Enzymes: Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrialMycophenolic Acid Metabolism Pathway (old)
smpdb.ca/view/SMP0000652Drug metabolismMycophenolic Acid (MPA) is an immunosuppressive agent that acts as a noncompetitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). … only) and CES-2 (in the liver and intestine).