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Displaying results 71 - 80 of 198 in total
  1. Pathway

    Levorphanol Action Pathway

    smpdb.ca/view/SMP0000673
    Drug action

    The binding of levorphanol will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Therefore, levorphanol can reduce nerve conduction and decrease neurotransmitter release; so that perception of pain signals can be blocked.

    Drugs: ATP · Norepinephrine · Levorphanol · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  2. Pathway

    Methadyl Acetate Action Pathway

    smpdb.ca/view/SMP0000678
    Drug action

    The binding of methadyl acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Therefore, methadyl acetate can reduce nerve conduction and decrease neurotransmitter release; so that perception of pain signals can be blocked.

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium · Methadyl acetate
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  3. Pathway

    Ethylmorphine Action Pathway

    smpdb.ca/view/SMP0000681
    Drug action

    Morphine can also bind and inhibit gamma-Aminobutyric acid (GABA) inhibitory interneurons. … Ethylmorphine (also known as codethyline and dionine) is an opioid analgesic. Ethylmorphine can be metabolized to form morphine by cytochrome P450 2D6 (CYP2D6).

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium · Ethylmorphine
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  4. Pathway

    Pentazocine Action Pathway

    smpdb.ca/view/SMP0000686
    Drug action

    Binding of pentazocine on mu-type opioid receptor and kappa-type opioid receptor can lead to decreased level of neuronal excitability and hyperpolarization. … Pentazocine can bind to mu-type opioid receptor and kappa-type opioid receptor on neuron of central nerves system (CNS).

    Drugs: ATP · Norepinephrine · Pentazocine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  5. Pathway

    Citalopram Action Pathway

    smpdb.ca/view/SMP0000424
    Drug action

    CREB-1 enters the nucleus and affects transcription of brain-derived neurotrophic factor (BDNF). … This increases the concentrations of serotonin in the synaptic cleft and reverses the state of low concentration seen in depression.

    Drugs: NADH · ATP · Citalopram · Norepinephrine · Dopamine · Potassium cation +5 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  6. Indication

    Hypoglycemia

    go.drugbank.com/conditions/DBCOND0020360
    Drugs: D-glucose · Dextrose, unspecified form
  7. Pathway

    Alvimopan Action Pathway

    smpdb.ca/view/SMP0000685
    Drug action

    Alvimopan is prescribed to treat patient opioid-induced constipation, a common side effect of opioid therapy. This side effect results in delayed discharge for hospitalized patients following surgery. Alvimopan helps to increase gastroin...

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium · Alvimopan
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Pathway

    Fluoxetine Action Pathway

    smpdb.ca/view/SMP0000426
    Drug action

    CREB-1 enters the nucleus and affects transcription of brain-derived neurotrophic factor (BDNF). … This increases the concentrations of serotonin in the synaptic cleft and reverses the state of low concentration seen in depression.

    Drugs: NADH · ATP · Norepinephrine · Fluoxetine · Dopamine · Potassium cation +4 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Morphine Action Pathway

    smpdb.ca/view/SMP0000406
    Drug action

    G(i) also activates potassium channels and inactivates calcium channels causing the neuron to hyperpolarize. … The end result is decreased nerve conduction and reduced neurotransmitter release, which blocks the perception of pain signals.

    Drugs: ATP · Morphine · Norepinephrine · Dopamine · Potassium cation · Calcium +1 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  10. Indication

    Haemodilution

    go.drugbank.com/conditions/DBCOND0007125
    Drugs: Sodium chloride