Search
Pseudoephedrine Action Pathway
smpdb.ca/view/SMP0125255Drug actionPseudoephedrine also inhibits sodium dependent noradrenaline receptors which prevents the reuptake of norepinephrine into the presynaptic neuron. … This causes norepinephrine to accumulate in the synapse which also activates alpha adrenergic receptors. These receptors then activate the Gq protein cascade.
Drugs: Ascorbic acid · Norepinephrine · Pseudoephedrine · Dopamine · Calcium · Magnesium cation +1 moreDroxidopa B2-Adrenergic Artery Dilation Action Pathway
smpdb.ca/view/SMP0126493Drug actionDroxidopa is an orally active synthetic precursor of norepinephrine that increases the deficient supply of norepinephrine in patients with NOH, thereby improving orthostatic blood pressure and alleviating … Norepinephrine binds to the beta-2 adrenergic receptor, the G protein signalling cascade begins.
Drugs: ATP · Norepinephrine · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphateImipramine
smpdb.ca/view/SMP0000422Drug actionHigher concentrations of norepinephrine and serotonin have also been shown to have long-term neuromodulatory effects. … Desipramine is an active metabolite and also has similar actions to imipramine on norepinephrine and serotonin reuptake.
Lidocaine (Local Anaesthetic) Action Pathway
smpdb.ca/view/SMP0000398Drug actionLidocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Lidocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated...
Methadone Action Pathway
smpdb.ca/view/SMP0000408Drug actionMethadone exerts its analgesic by acting on the mu-opioid receptor of sensory neurons. Binding to the mu-opioid receptor activates associated G(i) proteins. These subsequently act to inhibit adenylate cyclase, reducing the level of intra...
Caffeine Nervous Action Pathway
smpdb.ca/view/SMP0125297Drug actionIn the locus coeruleus caffeine activates the release of norepinephrine through an unknown mechanism. … Norepinephrine accumulates in the synapse and activates Alpha-1 adrenergic receptors and beta-1 adrenrgic receptors.
Drugs: Pyridoxal phosphate · Glutamic acid · Caffeine · Norepinephrine · Adenosine · Calcium +1 moreMorphine Action Pathway
smpdb.ca/view/SMP0000406Drug actionMorphine exerts its analgesic by acting on the mu-opioid receptor of sensory neurons. Binding to the mu-opioid receptor activates associated G(i) proteins. These subsequently act to inhibit adenylate cyclase, reducing the level of intrac...
Heroin Action Pathway
smpdb.ca/view/SMP0000407Drug actionHeroin is a mu-opioid agonist. It acts on endogenous mu-opioid receptors that are spread in discrete packets throughout the brain, spinal cord and gut in almost all mammals. Heroin, along with other opioids, are agonists to four endogeno...
Fluoxetine Action Pathway
smpdb.ca/view/SMP0000426Drug actionFluoxetine is a selective serotonin reuptake inhibitor that exerts antidepressive effects by selectively inhibiting serotonin reuptake in the brain. It does so by competing for the same binding site as serotonin on the the sodium-depende...
Catecholamine Biosynthesis
smpdb.ca/view/SMP0000012MetabolicThe commonly found catecholamines are epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. … The L-DOPA is then converted to dopamine via aromatic L-amino acid decarboxylase (AADC), which becomes norepinephrine via dopamine beta-hydroxylase (DBH); and finally is converted to epinephrine via phenylethanolamine
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 more