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Simethicone
go.drugbank.com/drugs/DB09512ApprovedInvestigational[A228308] It has a favourable safety profile as it is not systemically absorbed.[A228308] Simethicone has been in use since the 1940s[A228303] but was granted FDA approval in 1952.[A228308] … Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination.
Mixtures: Gelusil Antacid and Anti-gas, BROMURO DE OTILONIO + SIMETICONA 40MG + 200MGCategories: Compounds used in a research, industrial, or household settingPotassium Iodide
go.drugbank.com/drugs/DB06715ApprovedInvestigationalSSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyroidectomy. … Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperthyroidism (also known as thyroid storm or thyrotoxic crisis
Mixtures: Natalvirt Ca, Prenatal Vitamin-mineral Supplement Folic 5mgCategories: Cough and Cold PreparationsBarium sulfate
go.drugbank.com/drugs/DB11150ApprovedBarium sulfate is an inorganic compound with the chemical formula BaSO4 [L1957]. Barium sulfate occurs in nature as the mineral _barite_. … Barium sulfate is ingested by mouth or administered rectally and combined with granules of effervescent bicarbonate to enhance distension of the GI tract, allowing for enhanced gastrointestinal tract visualization
Categories: Compounds used in a research, industrial, or household settingProducts: Maxibar Liquid 210gm/100ml, BARIGRAF A.D.Melphalan
go.drugbank.com/drugs/DB01042ApprovedInvestigational[L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard. … [A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma.[L40928] It is also used for high-conditioning before hematopoietic stem cell transplant.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsSynonyms: p-N,N-bis(2-chloroethyl)amino-L-phenylalanine, p-N-Bis(2-chloroethyl)amino-L-phenylalanineIbrutinib
go.drugbank.com/drugs/DB09053ApprovedInvestigational[L45894] Ibrutinib was approved by the EMA in October 2014 [L45884] and by Health Canada in November 2014. … [A32299] Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval;[L12228] however, in
Categories: Antineoplastic and Immunomodulating AgentsSynonyms: 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-oneAlpha Linolenic Acid and Linoleic Acid Metabolism
smpdb.ca/view/SMP0000018MetabolicBoth LNA and ALA are essential dietary requirements for all mammals since they cannot be synthesized natively in the body. … LNA enters the cell and is catalyzed to gamma-linolenic acid (GLA) by acyl-CoA 6-desaturase (delta-6-desaturase/fatty acid desaturase 2).
Metabolism and Physiological Effects of Quinolinic Acid
smpdb.ca/view/SMP0123249MetabolicWhen this compound enters into systemic circulation it is shown to be a major uremic toxin when high levels of it are retained in the blood and not excreted in urine. … Quinolinic acid is an indole uremic toxin compound that is formed through metabolism from dietary tryptophan in liver hepatic cells.
Drugs: Tryptophan · Quinolinic Acid · Kynurenine · Mesoheme · Flavin adenine dinucleotide · 3-hydroxyanthranilic acid +1 moreEnzymes: Neutral and basic amino acid transport protein rBATMetabolism and Physiological Effects of Uric acid
smpdb.ca/view/SMP0124845MetabolicPurines can be made endogenously in the body or can be obtained exogenously from foods such as red meat. The purines are guanine and adenine. These undergo metabolism in the liver to form uric acid. … Uric acid can enter the blood and produce toxic effects on the cardiovascular, renal and joints, leading to cardiovascular disease, kidney disease and arthritis/ gout.
Metabolism and Physiological Effects of Oxalic acid
smpdb.ca/view/SMP0124875MetabolicThe oxalate formed in the liver form these 3 sources can enter the blood and have toxic effects in other tissues. Oxalate can promote cardiovascular disease, neurotoxicity and inflammation. … It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. Glyoxylate is generated through glycine and hydroxyproline catabolism and can be converted to oxalate.
Drugs: Pyridoxal phosphate · Ascorbic acid · Succinic acid · Glutamic acid · Glycine · Proline +4 moreEnzymes: Sodium- and chloride-dependent transporter XTRP3, Sodium- and chloride-dependent creatine transporter 1Metabolsim and Physiological Effects of Argininic acid
smpdb.ca/view/SMP0125504MetabolicIn a healthy individual arginine would then continue in the urea cycle to synthesize urea and ornithine, however, due to the deficiency in arginase, arginine is accumulates in the liver, causing hyperargininemia … Argininic acid is an uremic toxin produced in people with hyperargininemia. Hyperargininemia is an inborn problem in the urea cycle caused by a deficiency in liver arginase.
Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 more