Displaying drugs 876 - 900 of 11841 in total
Sevoflurane
Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996....
Approved
Vet approved
Matched Description: … [L42340] It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition ... Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. ... [A249910] Therefore, it can be used for inhalational induction in adults and children for a wide variety …
Latanoprostene bunod
Latanoprostene Bunod has been used in trials studying the treatment of Glaucoma, Ocular Hypertension, Open-Angle Glaucoma, Open Angle Glaucoma, and Intraocular Pressure.
As of November 2, 2017 the FDA approved Bausch + Lomb's Vyzulta (latanoprostene bunod opthalmic solution), 0.024% for the indication of reducing intraocular pressure in patients with open-angle...
Approved
Investigational
Matched Description: … In comparison, both latanoprost and latanoprostene bunod contain a latanoprost acid backbone. …
Lurasidone
Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States.
Approved
Investigational
Demeclocycline
A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Approved
Matched Description: … A tetracycline analog having a 7-chloro and a 6-methyl. …
Pindolol
Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the early 1970s....
Approved
Investigational
Matched Description: … Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. …
Teriflunomide
Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of hepatoxicity and...
Approved
Zalcitabine
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is...
Approved
Investigational
Matched Description: … a hydrogen. ... The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator ... A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by …
Remimazolam
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid...
Approved
Investigational
Matched Description: … [A214857] These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/ …
Curcumin
Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric (Curcuma longa) and in Curcuma xanthorrhiza oil. It is a highly pleiotropic molecule that exhibits antibacterial, anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities . Due to these properties, curcumin has been investigated for the treatment and...
Approved
Investigational
Matched Description: … It is a highly pleiotropic molecule that exhibits antibacterial, anti-inflammatory, hypoglycemic, antioxidant …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Isoprenaline
Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160]
Isoprenaline research in the 1940s found that this isopropyl analog of epinephrine dilated the bronchi, as well as raising...
Approved
Investigational
Matched Description: … a stronger action than [adrenaline]. ... Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes ... [A233724,A233729] The US patent from 1943 states that this compound had a wider therapeutic index and …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Phalaris arundinacea pollen
Phalaris arundinacea pollen is the pollen of the Phalaris arundinacea plant. Phalaris arundinacea pollen is mainly used in allergenic testing.
Approved
Atriplex lentiformis pollen
Atriplex lentiformis pollen is the pollen of the Atriplex lentiformis plant. Atriplex lentiformis pollen is mainly used in allergenic testing.
Approved
Agrostis stolonifera pollen
Agrostis stolonifera pollen is the pollen of the Agrostis stolonifera plant. Agrostis stolonifera pollen is mainly used in allergenic testing.
Approved
Polyquaternium-10 (400 cps at 2%)
Polyquaternium-10 is a quaternized hydroxyethyl cellulose and a polycationic polymer. It is commonly found in cosmetics and personal care products to mainly reduce static electricity and form films.
Approved
Matched Description: … Polyquaternium-10 is a quaternized hydroxyethyl cellulose and a polycationic polymer. …
Teicoplanin
Teicoplanin is a glycopeptide antibiotic consisting of a mixture of several compounds, five major (named teicoplanin A2-1 through A2-5) and four minor (named teicoplanin RS-1 through RS-4). All teicoplanins share a same glycopeptide core, teicoplanin A3-1, but differ in the length and conformation of side chains attached to their β-D-glucosamine...
Approved
Investigational
Matched Description: … Teicoplanin is a glycopeptide antibiotic consisting of a mixture of several compounds, five major (named ... All teicoplanins share a same glycopeptide core, teicoplanin A3-1, but differ in the length and conformation …
Methylphenobarbital
A barbiturate that is metabolized to phenobarbital. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital.
Approved
Matched Description: … A barbiturate that is metabolized to phenobarbital. …
Tropisetron
Tropisetron is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.
Tropisetron appears to be well tolerated with the most frequently reported adverse effect being headache. Extrapyramidal...
Approved
Investigational
Matched Description: … As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin …
Lemborexant
Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance. Recent research in the field of sleep disorders has revealed that insomnia is likely driven not by the inability of the brain to "switch on" sleep-related circuits,...
Approved
Investigational
Matched Description: … Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized ... This novel mechanism of action offers potential advantages over classic hypnotic agents, including a ... favorable adverse effect profile and potentially greater efficacy, and may signal the beginning of a …
Cimetidine
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Approved
Investigational
Matched Description: … Cimetidine has a range of pharmacological actions. ... A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. …
Colchicine
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events....
Approved
Matched Description: … Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum …
Raloxifene
Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and blood coagulation.[A4979,T28] Exhibiting tissue-specific effects distinct from estradiol, raloxifene is the first of the benzothiophene group of antiestrogens to be labelled a SERM....
Approved
Investigational
Matched Description: … Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic ... from [estradiol], raloxifene is the first of the benzothiophene group of antiestrogens to be labelled a ... However, it has a negligible effect on altering the development and progression of breast cancer itself …
Milk thistle
Milk thistle is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Investigational
Matched Description: … Milk thistle is a plant/plant extract used in some OTC (over-the-counter) products. …
Melphalan flufenamide
Melphalan flufenamide, also known as melflufen or J1, is a prodrug of melphalan.[A230123,L32173] Melphalan flufenamide is more readily uptaken by cells than melphalan, and is cleaved to the active metabolite by aminopeptidases. In vitro models show that melphalan is 10 to hundreds of times more potent than melphalan. The increased...
Approved
Withdrawn
Matched Description: … Melphalan flufenamide, also known as melflufen or J1, is a prodrug of [melphalan]. ... [A230123] The increased potency makes melphalan flufenamide a treatment option for patients with relapsed ... It has since been withdrawn from the market in the wake of the phase 3 OCEAN trial which showed a decrease …
Cetuximab
Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor (EGF). EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour cells; it is responsible...
Approved
Matched Description: … Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to ... [A227963] EGFR is often mutated in certain types of cancer and serves as a driver of tumorigenesis. ... [A227973] EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour …
Displaying drugs 876 - 900 of 11841 in total