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Displaying drugs 701 - 725 of 14979 in total

Avacopan

Anti-neutrophil cytoplasmic (auto)antibody (ANCA)-associated vasculitis (AAV) is a rare (estimated incidence of 3 cases per 100,000 per year) form of "pauci-immune" systemic small-vessel vasculitis typified by the presence of ANCAs in the serum.[A240249, A240254, A227003] The full spectrum of AAV includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis...
Approved
Investigational
Matched Description: … AAV may be associated with necrotizing and crescentic glomerulonephritis (NCGN). ... , in particular, the interaction between the anaphylatoxin fragment C5a and its cognate C5aR receptor ... [A240269, A240329, L38919] Avacopan was granted FDA approval on October 8, 2021, and is currently …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Selpercatinib

Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including cabozantinib, ponatinib, sorafenib, sunitinib, and vandetanib, have shown efficacy in RET-driven cancers, their...
Approved
Investigational
Matched Description: … Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and ... Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Diacerein

Diacerein is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea . Diacerein is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2),...
Approved
Investigational
Matched Iupac: … 4,5-bis(acetyloxy)-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid …
Matched Description: … Diacerein is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Valproate bismuth

Valproate bismuth is available in Canada in the over-the-counter medication Neo-Laryngobis.
Approved

Bordetella pertussis fimbriae 2/3 antigen

Bordetella pertussis fimbriae 2/3 antigen is a vaccine for the prophylaxis of the disease caused by Bordetella pertussis which is a a Gram-negative coccobacillus that expresses two serologically distinct fimbriae (Fim2 and Fim3).
Approved
Investigational
Matched Description: … pertussis which is a a Gram-negative coccobacillus that expresses two serologically distinct fimbriae (Fim2 and …
Matched Mixtures name: … FILAMENTOUS HEMAGGLUTININ ANTIGEN (FORMALDEHYDE INACTIVATED), BORDETELLA PERTUSSIS PERTACTIN ANTIGEN, and …

Isoxicam

Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States.
Approved
Withdrawn

Piroxicam

A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
Approved
Investigational
Matched Description: … osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. ... non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Topical Products for Joint and Muscular Pain ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Iopromide

Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can cause several serious adverse effects, including...
Approved
Matched Description: … [A260751] Although the mechanism is unclear, women and outpatients tend to have a higher incidence of ... several serious adverse effects, including cardiac events, thromboembolism, hypersensitivity reaction, and ... brain computer tomography (CT), coronary arteriography, left ventriculography, visceral angiography, and …

Ingenol mebutate

Ingenol mebutate was approved by the FDA in January 2012, and it is marketed under the name Picato®. Picato gel is indicated for the topical treatment of actinic keratosis. Before approval, ingenol mebutate was called PEP005 as an investigational drug. PEP005 is a selective small molecule activator of protein kinase...
Approved
Matched Description: … Ingenol mebutate was approved by the FDA in January 2012, and it is marketed under the name Picato®. ... whose sap has been used as a traditional medicine for the treatment of skin conditions including warts and ... PEP005 also has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary …
Matched Categories: … Skin and Mucous Membrane Agents …

Cobicistat

Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic exposure of coadministered agents that are metabolized...
Approved
Matched Description: … exposure of anti-retrovirals (ARVs) without increasing dosage allows for better treatment outcomes and ... activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and …
Matched Categories: … darunavir and cobicistat ... atazanavir and cobicistat ... Metabolic Side Effects of Drugs and Substances ... emtricitabine, tenofovir alafenamide, darunavir and cobicistat ... emtricitabine, tenofovir disoproxil, elvitegravir and cobicistat …

Gabapentin enacarbil

Gabapentin enacarbil is marketed under the name Horizant. It is a prodrug of gabapentin, and indicated in adults for the treatment of Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
Approved
Investigational
Matched Iupac: … 2-(1-{[({1-[(2-methylpropanoyl)oxy]ethoxy}carbonyl)amino]methyl}cyclohexyl)acetic acid …
Matched Description: … ) and postherpetic neuralgia (PHN). ... It is a prodrug of gabapentin, and indicated in adults for the treatment of Restless Legs Syndrome (RLS …
Matched Categories: … Gabapentin and Prodrugs ... Amino Acids, Peptides, and Proteins …

Oxyphenbutazone

Oxyphenbutazone was withdrawn from the Canadian market in March 1985 due to concerns regarding bone marrow suppression.
Approved
Withdrawn
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Topical Products for Joint and Muscular Pain ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Asenapine

Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use....
Approved
Matched Description: … International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and …
Matched Categories: … Acid Reducers ... Diazepines, Oxazepines, Thiazepines and Oxepines …

Primaquine

An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of...
Approved
Matched Description: … An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale ... Adverse effects include anemias and GI disturbances. …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …

Dexfenfluramine

Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.
Approved
Illicit
Investigational
Withdrawn
Matched Categories: … Alimentary Tract and Metabolism …

Halofantrine

Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferentially block open and...
Approved
Matched Description: … It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. ... Halofantrine has been shown to preferentially block open and inactivated HERG channels leading to some …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …

Fenoterol

Fenoterol is an adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.
Approved
Investigational
Matched Description: … Fenoterol is an adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic. …
Matched Categories: … fenoterol and ipratropium bromide ... Genito Urinary System and Sex Hormones …

Mephentermine

A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra...
Approved
Matched Categories: … Adrenergic and Dopaminergic Agents …

Molindone

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate...
Approved
Matched Description: … An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment ... It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. ... Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively …

Huperzine A

Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has been used in China for centuries for the treatment of swelling, fever and blood disorders. Recently in clinical trials in China, it has demonstrated neuroprotective effects. It is currently being...
Approved
Experimental
Matched Description: … The botanical has been used in China for centuries for the treatment of swelling, fever and blood disorders …

Dimetindene

Dimetindene (Fenistil) is an antihistamine/anticholinergic used orally and locally as an antipruritic.
Approved
Investigational
Matched Description: … Dimetindene (Fenistil) is an antihistamine/anticholinergic used orally and locally as an antipruritic …

Efinaconazole

Efinaconazole is a 14 alpha-demethylase inhibitor indicated in the treatment of fungal infection of the nail, known as onychomycosis. It was approved for use in Canada and the USA in 2014 and is marketed by Valeant Pharmaceuticals North America LLC under the name Jublia.
Approved
Matched Description: … It was approved for use in Canada and the USA in 2014 and is marketed by Valeant Pharmaceuticals North …
Matched Categories: … Imidazole and Triazole Derivatives …

Iofetamine I-123

Approved
Matched Categories: … Indicators and Reagents …

Amifampridine

Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations . It was first discovered in Scotland in the 1970s and its clinical effectiveness for neuromuscular disorders, including Lambert–Eaton myasthenic syndrome (LEMS), has been investigated...
Approved
Investigational
Matched Description: … subsequently prolongs the action potential and increases presynaptic calcium concentrations [A33863] ... diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and ... It is currently used as the first-line symptomatic treatment for LEMS in adult patients and is ideally …

Capmatinib

Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or overexpression - is known to occur in many...
Approved
Investigational
Matched Description: … such as STAT3, PI3K/ATK, and RAS/MAPK. ... [A199122] Aberrant c-Met activation - via mutations, amplification, and/or overexpression - is known ... tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Displaying drugs 701 - 725 of 14979 in total