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Displaying drugs 226 - 250 of 15151 in total

Lumiracoxib

Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in Australia due to concerns that it may cause liver failure. New Zealand and Canada have also followed suit in recalling...
Approved
Investigational
Matched Description: … New Zealand and Canada have also followed suit in recalling the drug. …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Ceftazidime

Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs). β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of essential PBPs, result in impaired cell wall homeostasis,...
Approved
Matched Iupac: … carboxy-1-methylethoxy)imino]acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl …
Matched Description: … a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and ... through inhibition of essential PBPs, result in impaired cell wall homeostasis, loss of cell integrity, and ... [L32935] Ceftazidime was approved by the FDA on July 19, 1985, and is currently available either alone …
Matched Products: … Ceftazidime and Dextrose ... CEFTAZIDIME ALVOGEN POWDER FOR SOLUTION FOR INJECTION AND INFUSION 1G/ VIAL …

Hydrochlorothiazide

Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459] Hydrochlorothiazide was granted FDA...
Approved
Vet approved
Matched Description: … [A185138] It is indicated to treat edema and hypertension. ... [A185138] Many combination products are available containing hydrochlorothiazide and angiotensin converting …
Matched Mixtures name: … Lisinopril and HCTZ ... Lisinopril and Hydrochlorothiazide ... Lisinopril and Hydrochlorothiazide …
Matched Categories: … hydrochlorothiazide and potassium ... aliskiren and hydrochlorothiazide ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... ramipril, amlodipine and hydrochlorothiazide …
Matched Products: … Losartan Potassium and Hydrochlorothiazide …

Mephenesin

Mephenesin is a synthetic cresol glyceryl ether which produces transient muscle relaxation and paralysis via central nervous system depression . It first entered use in the 1950s.
Approved
Matched Description: … Mephenesin is a synthetic cresol glyceryl ether which produces transient muscle relaxation and paralysis …

Atomoxetine

Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve developmentally inappropriate symptoms associated with ADHD including distractibility, short attention...
Approved
Matched Iupac: … methyl[(3R)-3-(2-methylphenoxy)-3-phenylpropyl]amine …
Matched Description: … blocks the N-methyl-d-aspartate (NMDA) receptor,[A18263] indicating a role for the glutamatergic system ... considered the most effective and first-line treatment for ADHD in adults and children as recommended ... addictive properties, and even amplifies the potency and reinforcing effects of other drugs of abuse …
Matched Categories: … Psychostimulants, Agents Used for ADHD and Nootropics …

Levocarnitine

Constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.
Approved
Investigational
Matched Description: … Constituent of striated muscle and liver. ... It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias …
Matched Categories: … Amino Acids and Derivatives ... Alimentary Tract and Metabolism …

Valproic acid

Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into...
Approved
Investigational
Matched Description: … Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in ... [A178051] It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for ... It is currently a compound of interest in the field of oncology for its anti-proliferative effects and …

Tixocortol

Tixocortol is a 21-thiol derivative of hydrocortisone classified as a class A corticosteroid. It is a synthetic steroid with topical anti-inflammatory properties without the systemic glucocorticoid and mineralocorticoid activities and toxicity.
Approved
Withdrawn
Matched Description: … and mineralocorticoid activities and toxicity. ... It is a synthetic steroid with topical anti-inflammatory properties without the systemic glucocorticoid …
Matched Categories: … Alimentary Tract and Metabolism ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Nabumetone

Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a degree...
Approved
Matched Description: … Nabumetone was developed by Smithkline Beecham under the trade name Relafen and first received FDA approval …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Ketoconazole

Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation...
Approved
Investigational
Matched Iupac: … 1-[4-(4-{[2-(2,4-dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin …
Matched Description: … [clotrimazole], due to its broad spectrum and good absorption. ... Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal ... Ketoconazole and its predecessor [clotrimazole] continue to be used in topical formulations. …
Matched Categories: … Sex Hormones and Insulins ... Imidazole and Triazole Derivatives ... Gynecological Antiinfectives and Antiseptics ... Metabolic Side Effects of Drugs and Substances …

Prednisone

A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver. Prednisone was granted FDA approval on 21 February 1955.
Approved
Vet approved
Matched Description: … A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. ... [A187463] It is biologically inert and converted to [prednisolone] in the liver. …
Matched Categories: … Alimentary Tract and Metabolism ... Prednisolone and Prodrugs ... Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Triamcinolone

Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermatoses. Triamcinolone is more...
Approved
Vet approved
Matched Description: … Triamcinolone is more commonly seen in the forms triamcinolone hexacetonide, triamcinolone acetonide, and …
Matched Mixtures name: … Nystatin and Triamcinolone ... Nystatin and Triamcinolone ... Nystatin and Triamcinolone …
Matched Categories: … Alimentary Tract and Metabolism ... Sex Hormones and Insulins ... triamcinolone and antiseptics ... triamcinolone and antibiotics ... triamcinolone and antiinfectives …
Matched Products: … Up and Up Nasal Allergy ... Foster and Thrive 24 Hour Nasal Allergy …

Butorphanol

A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.
Approved
Illicit
Vet approved
Matched Description: … A synthetic morphinan analgesic with narcotic antagonist action. …

Clomifene

A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Approved
Investigational
Matched Categories: … Ovulation Stimulants, Synthetic ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Hydrocortisone acetate

Approved
Vet approved
Matched Mixtures name: … Neomycin and Polymyxin B Sulfates and Bacitracin Zinc with Hydrocortisone Acetate ... Neomycin and Polymyxin B Sulfates and Bacitracin Zinc with Hydrocortisone Acetate ... Neomycin and Polymyxin B Sulfates and Bacitracin Zinc with Hydrocortisone Acetate …
Matched Categories: … Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … American Safety and First Aid …

Methocarbamol

Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether. Methocarbamol tablets and intramuscular injections are prescription medicines indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of...
Approved
Vet approved
Matched Description: … Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated ... [A178450] Methocarbamol tablets and intramuscular injections are prescription medicines indicated ... in the United States as an adjunct to rest, physical therapy, and other measures for the relief of discomforts …
Matched Mixtures name: … Methocarbamol and Aspirin ... Muscle and Back Pain Relief ... Muscle and Back Pain Relief …
Matched Categories: … Methyl Ethers …

Liotrix

Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion....
Approved
Matched Description: … and combination hormone replacement therapy generally offers no therapeutic advantage. ... It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in ... It is now known that the thyroid gland secretes approximately ten times more T4 than T3 and that 80% …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Azithromycin

Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration . It was initially approved by the FDA in 1991 . It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for...
Approved
Matched Description: … , and contains a 15-membered ring, with a methyl-substituted nitrogen instead of a carbonyl group at ... Azithromycin [9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin] is a part of the _azalide_ subclass of macrolides ... It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be …
Matched Categories: … cefixime and azithromycin ... azithromycin, fluconazole and secnidazole ... Macrolides, Lincosamides and Streptogramins …

Methylergometrine

A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)
Approved
Matched Iupac: … (4R,7R)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1 …
Matched Categories: … Ergot Alkaloids and Derivatives ... methylergometrine and oxytocin ... Genito Urinary System and Sex Hormones …

Carglumic acid

Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl glutamate synthase. This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and cause neurologic problems, cerebral edema, coma, and death. Carglumic acid was...
Approved
Matched Description: … Food and Drug Administration (FDA) on 18 March 2010. ... cause neurologic problems, cerebral edema, coma, and death. ... disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and …
Matched Categories: … Amino Acids and Derivatives ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Eplerenone

Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of...
Approved
Matched Iupac: … methyl (1'R,2R,2'S,9'R,10'R,11'S,15'S,17'R)-2',15'-dimethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo …
Matched Description: … antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and ... The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the ... mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Propantheline

A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Approved
Matched Description: … A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment …
Matched Categories: … Synthetic Anticholinergics, Quaternary Ammonium Compounds ... Alimentary Tract and Metabolism ... propantheline and psycholeptics …

Methscopolamine

Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective...
Approved
Matched Description: … Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh ... The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be …
Matched Categories: … Synthetic Anticholinergics, Quaternary Ammonium Compounds ... Alimentary Tract and Metabolism ... Mydriatics and Cycloplegics ... Belladonna and Derivatives, Plain ... methylscopolamine and psycholeptics …

Acetohydroxamic acid

Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics...
Approved
Matched Description: … Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure ... Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. …
Matched Categories: … Genito Urinary System and Sex Hormones …

Melphalan

Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem...
Approved
Matched Description: … [A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. ... [L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Displaying drugs 226 - 250 of 15151 in total