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Displaying drugs 2476 - 2500 of 15094 in total

Parachlorophenol

P-chlorophenol is a white crystals with a strong phenol odor. Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible.
Approved
Matched Description: … Slightly soluble to soluble in water, depending on the isomer, and denser than water. …

Ticlopidine

Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot...
Approved
Matched Description: … Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin ... includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and ... agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine …
Matched Categories: … Blood and Blood Forming Organs ... Metabolic Side Effects of Drugs and Substances …

Sotorasib

Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.[A187547,A187556] It is indicated in the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer. This mutation makes up >50% of all KRAS mutations. Mutant KRAS discovered in 1982 but was not considered a druggable...
Approved
Investigational
Matched Description: … [A187547] The drug [MRTX849] is also currently being developed and has the same target. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Diazoxide

Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release....
Approved
Matched Description: … and electrolyte disturbances. ... [A255647] Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular ... A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and …

Technetium Tc-99m pyrophosphate

A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the...
Approved
Matched Description: … used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and …
Matched Categories: … Indicators and Reagents …

Thiothixene

A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Approved

Tafenoquine

Tafenoquine is an 8-aminoquinoline analogue of primaquine which varies only on the presence of a 5-phenoxy group.[A35671, A35690] It was discovered by the scientists at the Walter Reed Army Institute of Research in 1978 as a substitute for primaquine that would be more effective against relapsing vivax malaria. Tafenoquine was...
Approved
Investigational
Matched Description: … [A35690] Tafenoquine was further developed collaboratively between GlaxoSmithKline and Medicines for …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …

Hydroxychloroquine

Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like chloroquine. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is also used for the prophylaxis of malaria in...
Approved
Matched Description: … Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. ... the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and ... [A183092] Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …

Janssen COVID-19 Vaccine

The Janssen COVID-19 vaccine (Ad26.COV2.S) is a recombinant vaccine that contains an adenovirus serotype 26 (Ad26) vector expressing a stabilized SARS-CoV-2 spike protein. The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and the Beth Israel Deaconess Medical Center. A preclinical study in hamsters infected with...
Approved
Investigational
Matched Description: … The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and ... -2 infection[A220053] showed a single immunization with the vaccine-elicited neutralizing responses and ... protected against SARS-CoV-2 induced pneumonia and mortality, providing protection against the disease …

Oxcarbazepine

Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of carbamazepine and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate...
Approved
Matched Description: … [L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Ticagrelor

Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y12 receptor antagonism. Unlike clopidogrel, ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU, . Ticagrelor was...
Approved
Matched Description: … [A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] and Brilique or Possia in the EU …
Matched Categories: … Blood and Blood Forming Organs ... Nucleic Acids, Nucleotides, and Nucleosides …

Gallamine triethiodide

A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may...
Approved
Matched Description: … may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. ... gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and …

Formaldehyde

A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor...
Approved
Vet approved
Matched Description: … , and as a laboratory fixative or preservative. ... Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. ... In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant …

Verteporfin

Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: CL-315555 and CL-315585. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red...
Approved
Investigational
Matched Description: … as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: [CL-315555] and ... Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light ... wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and …

Ritodrine

Adrenergic beta-agonist used to control premature labor.
Approved
Investigational
Matched Categories: … Genito Urinary System and Sex Hormones …

Foreskin keratinocyte (neonatal)

Skin, the largest organ of the human body, plays the main role in protecting the body from mechanical damage. It is composed of epidermal, dermal and hypodermal layers. The barrier function of the skin owed to its avascular epidermal layer, which is made mainly of keratinocytes. The keratinocytes form a...
Approved
Matched Description: … of [DB10770] and keratinocytes. ... It is composed of epidermal, dermal and hypodermal layers. ... keratinized, and mostly impermeable outer stratum corneum layer on the surface [L2452]. …

Modified vaccinia ankara

Modified Vaccinia Ankara (MVA) refers to an attenuated strain of the Vaccinia virus. Vaccines using MVA are live and non-replicating, and are produced using Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN).[L42660,L42670]
Approved
Matched Description: … Vaccines using MVA are live and non-replicating, and are produced using Modified Vaccinia Ankara-Bavarian …

Desvenlafaxine

Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of venlafaxine. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of adults with major depressive disorder (MDD).[L6016,A261271] MDD is a highly...
Approved
Investigational
Matched Description: … a highly prevalent psychiatric disorder, with a lifetime prevalence estimate of 16% in the US alone and ... [A261271] Desvenlafaxine has a very similar pharmacological, efficacy, and safety profile as [venlafaxine …
Matched Categories: … Serotonin and Noradrenaline Reuptake Inhibitors …

Antithrombin Alfa

Antithrombin Alfa is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations.
Approved
Investigational

Crotalus atrox antivenin

Each year it is estimated there are 45,000 snakebites in the US and 300,000 to 400,000 bites worldwide. About 8000 of these snakebites involve venomous snake species. The majority of people bitten are males and about 50% occur in the age group of 18 to 28 . Crotalus atrox antivenin...
Approved
Experimental
Matched Description: … Each year it is estimated there are 45,000 snakebites in the US and 300,000 to 400,000 bites worldwide ... isolating the antivenin of interest through fractionation and chromatography techniques. ... The majority of people bitten are males and about 50% occur in the age group of 18 to 28 [F113]. …

Isoeugenol

Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally in the essential oils of plants such as ylang-ylang. It is also a significant dermatologic sensitizer and allergen, and as a result has been restricted to 200 p.p.m. since 1998 according to guidelines issued by...
Approved
Experimental
Matched Description: … It is also a significant dermatologic sensitizer and allergen, and as a result has been restricted to ... Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally …

Phenacemide

Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures.
Approved
Matched Description: … This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures. …

Aluminum oxide

Aluminum oxide has a chemical formula Al2O3. It is amphoteric in nature, and is used in various chemical, industrial and commercial applications. It is considered an indirect additive used in food contact substances by the FDA.
Approved
Matched Description: … It is amphoteric in nature, and is used in various chemical, industrial and commercial applications. …

Tripelennamine

A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.
Approved
Vet approved
Matched Description: … It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. …

Carbinoxamine

Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and...
Approved
Matched Description: … The product label for carbinoxamine as an over the counter cough and cold medicine is being modified ... to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many ... labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and …
Displaying drugs 2476 - 2500 of 15094 in total