Displaying drugs 2476 - 2500 of 15064 in total
Brolucizumab
Brolucizumab, also known as RTH258 or ESBA1008, is a monoclonal antibody indicated to treat neovascular age related macular degeneration. Brolucizumab was granted FDA approval in October 2019.
Approved
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins …
Xenon-133
Xenon-133 is an inhaled radionuclide used for lung imaging, imaging blood flow in the brain, and to assess pulmonary function.
Approved
Matched Description: … Xenon-133 is an inhaled radionuclide used for lung imaging, imaging blood flow in the brain, and to assess …
Carvedilol
Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as...
Approved
Investigational
Matched Description: … , and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. ... Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker ... [L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension …
Matched Categories: … carvedilol and ivabradine ... Alpha and Beta Blocking Agents ... Calcium-Regulating Hormones and Agents …
Matched Categories: … carvedilol and ivabradine ... Alpha and Beta Blocking Agents ... Calcium-Regulating Hormones and Agents …
Agkistrodon piscivorus antivenin
Agkistrodon piscivorus antivenin is derived and purified immunoglobulin fragments obtained from other domestic animals such as sheep previously immunized with Agkistrodon piscivorus (Cottonmouth or Water Moccasin snake). The final purified antivenin product is obtained by mixing other different monospecific snake antivenins and isolating the antivenin of interest through fractionation and...
Approved
Experimental
Matched Description: … Sistrurus spp.) and the copperheads and cottonmouth water moccasins (Agkistrodon spp.) ... isolating the antivenin of interest through fractionation and chromatography techniques. ... Agkistrodon piscivorus antivenin is derived and purified immunoglobulin fragments obtained from other …
Bithionol
Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the NDA's for bithionol drug products were withdrawn on October 24, 1967 (see the Federal Register of October 31, 1967 (32...
Approved
Withdrawn
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …
Fludeoxyglucose (18F)
Fludeoxyglucose F 18 Injection is a positron emitting radiopharmaceutical containing no-carrier added radioactive 2-deoxy-2-[18F]fluoro-D-g1ucose, which is used for diagnostic purposes in conjunction with Positron Emission Tomography (PET). It is administered by intravenous injection.
Approved
Investigational
Matched Categories: … Indicators and Reagents …
Human papillomavirus type 6 L1 capsid protein antigen
Human papillomavirus type 6 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus...
Approved
Investigational
Matched Description: … by Human Papillomavirus (HPV) types 6, 11, 16 and 18. ... antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and ... It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused …
Povidone K30
A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander. See povidone for full details.
Approved
Experimental
Matched Description: … A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle …
Phenytoin
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as...
Approved
Vet approved
Matched Description: … Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one ... [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market. ... has also been investigated for several other indications such as bipolar disorder, retina protection, and …
Matched Categories: … Phenytoin and Prodrugs ... Metabolic Side Effects of Drugs and Substances …
Matched Categories: … Phenytoin and Prodrugs ... Metabolic Side Effects of Drugs and Substances …
DL-Methylephedrine
Methylephedrine is a sympathomimetic amine that appears in various over-the-counter cough and cold medications throughout the world , , . The abuse of methylephedrine-containing medications has been reported in Japan. Methylephedrine is not legally available in the United States, but has been identified in cases of drug abuse .
Approved
Matched Description: … Methylephedrine is a sympathomimetic amine that appears in various over-the-counter cough and cold medications …
Metaxalone
Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous system depression. Metaxalone...
Approved
Matched Description: … Metaxalone is associated with few side effects and is available as a 800 mg scored tablet. ... muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and …
Amantadine
An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and...
Approved
Matched Description: … It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic ... effects in movement disorders are not well understood but probably reflect an increase in synthesis and …
Pyridostigmine
Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of choice in myasthenia gravis since the 1930s with the...
Approved
Investigational
Matched Description: … under various brand and generic names. ... directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and ... By inhibiting the breakdown of acetylcholine in the neuromuscular junction, they increase signalling and …
Anisindione
Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S,...
Approved
Matched Description: … Anisindione is a synthetic anticoagulant and an indanedione derivative. ... X, as well as the anticoagulant proteins C and S, in the liver. ... precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and …
Indium In-111 oxyquinoline
Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detected with a gamma ray...
Approved
Matched Description: … The degree of accuracy may vary with labeling techniques and with the size, location and nature of the ... It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. ... Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that …
Pimozide
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994,...
Approved
Matched Description: … for the suppression of vocal and motor tics in patients with Tourette syndrome. ... A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol …
Fluoride ion F-18
Sodium Fluoride F 18 Injection is a positron emitting radiopharmaceutical, no-carrier added. It contains radioactive fluoride F 18 that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging and is administered by intravenous injection. Its primary indication is for bone imaging. Increased deposition around joints can...
Approved
Matched Description: … Increased deposition around joints can occur in arthritis and following trauma and increased deposition ... that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging and ... has been noted around fracture sites, in osteomyelitis, fibrous dysplasia, spondylitis tuberculosa, and …
Levosalbutamol
Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Salbutamol has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective disposition of salbutamol and the possibility that (S)-salbutamol has...
Approved
Investigational
Matched Description: … , or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and ... The enantioselective disposition of salbutamol and the possibility that (S)-salbutamol has adverse effects …
Ibritumomab tiuxetan
Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and...
Approved
Investigational
Matched Description: … of 445 amino acids each and two kappa light chains of 213 amino acids each. ... kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and ... Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Crotalus scutulatus antivenin
Crotalus scutulatus antivenin is derived and purified immunoglobulin fragments obtained from other domestic animals such as sheep previously immunized with Crotalus scutulatus (also known as the Mojave rattlesnake ).
The final purified antivenin product is obtained by mixing other different monospecific snake antivenins and isolating the antivenin of interest through...
Approved
Experimental
Matched Description: … isolating the antivenin of interest through fractionation and chromatography techniques. ... Crotalus scutulatus antivenin is derived and purified immunoglobulin fragments obtained from other domestic ... Mojave rattlesnakes inhabit desert areas of the southwestern United States and central Mexico. …
Tilmanocept
Tilmanocept is under investigation in clinical trial NCT03241446 (Pharmacokinetics and Dosimetry of Tc 99m Tilmanocept Following a Single Intravenous Dose Administration in Male and Female Subjects Diagnosed With Rheumatoid Arthritis (RA)).
Approved
Investigational
Matched Description: … Tilmanocept is under investigation in clinical trial NCT03241446 (Pharmacokinetics and Dosimetry of Tc ... 99m Tilmanocept Following a Single Intravenous Dose Administration in Male and Female Subjects Diagnosed …
Methylchloroisothiazolinone
Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties. It is found within many commercially available cosmetics, lotions, and makeup removers. It is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness,...
Approved
Experimental
Matched Description: … It is found within many commercially available cosmetics, lotions, and makeup removers. ... scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area. ... Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and …
Iodoform
Iodoform is an organoiodine compound with the formula CHI3 and a tetrahedral molecular geometry. It is a relatively water-insoluble yellow solid that is chemically reactive in free-radical reactions . Due to its antimicrobial properties following topical administration, minimal levels of iodoform may be found in disinfectants and it is more...
Approved
Experimental
Vet approved
Matched Description: … Iodoform is an organoiodine compound with the formula CHI3 and a tetrahedral molecular geometry. ... dressing or powder for wounds and sores, however such clinical use to this date is limited. ... Since the beginning of the 20th century, iodoform has been commonly used as a healing and antiseptic …
Bosutinib
Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR-ABL fusion protein.[A6902,A261796,A261801] The first BCR-ABL inhibitor,...
Approved
Matched Description: … Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine ... BCR-ABL inhibitors like bosutinib inhibit most resistance-conferring BCR-ABL mutations except V299L and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Voretigene neparvovec
Voretigene Neparvovec-rzyl (VN-rzyl) is an adeno-associated virus vector-based gene therapy. An adeno-associated virus is a small virus that infects humans and other primates. It is not pathogenic and it causes a very mild immune response. This type of virus is vastly used as vectors for gene therapy because they can...
Approved
Matched Description: … It is not pathogenic and it causes a very mild immune response. ... [L1094] An adeno-associated virus is a small virus that infects humans and other primates. ... [A31478] VN-rzyl was developed by Spark Therapeutics Inc. and FDA approved on December 19, 2017. …
Displaying drugs 2476 - 2500 of 15064 in total