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Displaying drugs 2676 - 2700 of 9733 in total

Omidenepag isopropyl

Omidenepag isopropyl is a topical ocular hypotensive agent used to reduce intraocular pressure (IOP) in patients with glaucoma and ocular hypertension. Omidenepag isopropyl is quickly metabolized to its active metabolite, omidenepag, a molecule with high selectivity and agonistic activity towards the prostaglandin E2 (EP2) receptor.[A253263,A253268] Prostanoid FP receptor agonists (FP...
Approved
Investigational
Matched Description: … [A253268] In September 2022, the FDA approved the use of omidenepag isopropyl.[L43503] ... The use of an EP2 receptor agonist such as omidenepag represents an alternative in these scenarios. ... [A253263,A253268] Prostanoid FP receptor agonists (FP agonists), such as [latanoprost], are part of the …
Matched Categories: … combinations of sulfonamides …

Tocilizumab

Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 January 2010 to treat a...
Approved
Matched Description: … autoimmune disorders, such as different types of arthritis and cytokine release syndrome. ... [A193281] Tocilizumab was granted FDA approval on 8 January 2010 to treat a number of inflammatory and ... [L12789] It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing …

Eladocagene exuparvovec

Eladocagene exuparvovec is a recombinant adeno-associated virus-2 (AAV2)-based gene therapy that expresses human aromatic L-amino acid decarboxylase (AADC), and it is used to treat AADC deficiency, a fatal and rare genetic disorder that causes severe disability in pediatric patients.[L43642,L43672] Patients with AADC have mutations in the dopa decarboxylase (DDC) gene...
Approved
Investigational
Matched Description: … By promoting the expression of AADC, eladocagene exuparvovec leads to the development of motor function ... [A253697,L43672] Before the approval of this gene therapy, the treatment options for patients with AADC …

Oxazepam

Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine lorazepam, is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feature is advantageous as compared to other benzodiazepines, and is likely owing in...
Approved
Matched Description: … Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal ... [A203516] It is an active metabolite of both [diazepam] and [temazepam][A39486] and undergoes very little …

Reboxetine

Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. Reboxetine has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine.
Approved
Experimental
Matched Iupac: … (2R)-2-[(R)-(2-ethoxyphenoxy)(phenyl)methyl]morpholine …
Matched Description: … Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ... Reboxetine has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine …

Rabies immune globulin, human

IMOGAM Rabies Pasteurized is indicated for post-exposure prophylaxis in persons suspected of exposure to rabies, who have not previously received a complete immunization regimen with a cell culture produced rabies vaccine. Persons previously vaccinated with other types of rabies vaccines in whom adequate antibody levels have not been demonstrated should...
Approved
Matched Description: … IMOGAM Rabies Pasteurized is indicated for post-exposure prophylaxis in persons suspected of exposure ... Persons previously vaccinated with other types of rabies vaccines in whom adequate antibody levels have ... If IMOGAM Rabies Pasteurized is not administered as recommended at the initiation of the post-exposure …
Matched Products: … BERIRAB(R) P …

Etodolac

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.
Approved
Investigational
Vet approved
Matched Description: … It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. …

Mavacamten

Mavacamten is a myosin inhibitor indicated for the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM). It received initial US FDA approval in 2022, and it is one of the first myosin inhibitors to be used in humans. Mavacamten was also approved...
Approved
Investigational
Matched Description: … Mavacamten is a myosin inhibitor indicated for the treatment of adults with symptomatic New York Heart ... It received initial US FDA approval in 2022, and it is one of the first myosin inhibitors to be used …

Prednicarbate

Prednicarbate is a relatively new topical corticosteroid drug that displays a similar potency as hydrocortisone. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a...
Approved
Investigational
Matched Description: … The anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin ... It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. ... It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency …
Matched Products: … DERMATOP (R) CREAM …

Glymidine

Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta...
Approved
Investigational
Matched Description: … The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating ... the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral ... and increasing the sensitivity of peripheral tissues to insulin. …
Matched Categories: … combinations of sulfonamides …

Butoconazole

Butoconazole is an imidazole antifungal used in gynecology.
Approved
Matched Categories: … combinations of imidazole derivatives …

Sodium cellulose phosphate

Sodium cellulose phosphate is used to treat hypercalcemia and hypercalciuria. It has been used to prevent kidney stones. This compound is an ion-exchange resin that can not be absorbed by the body. However, it can be used to restore normal intestinal calcium absorption.
Approved
Matched Categories: … Drugs for Treatment of Hypercalcemia …

Tiludronic acid

Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to etidronic acid and clodronic acid.[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described in the literature in 1988 as a potential treatment for Paget's disease of bone....
Approved
Investigational
Vet approved
Matched Description: … [A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification ... Tiludronic acid was first described in the literature in 1988 as a potential treatment for Paget's disease of …
Matched Categories: … Drugs for Treatment of Bone Diseases …

Diclofenamide

A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
Approved
Investigational
Matched Description: … A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. …
Matched Categories: … combinations of sulfonamides …

Mazindol

Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than amphetamine, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. Mazindol is only approved in the United States for the treatment of Duchenne...
Approved
Investigational
Matched Description: … It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter ... is not marketed or available in the United States for use in the treatment of obesity. ... Mazindol is only approved in the United States for the treatment of Duchenne muscular dystrophy, and …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Lymecycline

Lymecycline is a broad-spectrum second-generation tetracycline antibiotic used for the treatment of acne and other susceptible bacterial infections.[L13880,L13883] It has been proven a cost-effective alternative to treatment with minocycline with comparable safety and efficacy. Lymecycline was initially discovered in 1961. It is marketed by Galderma and used in the UK...
Approved
Investigational
Matched Description: … Lymecycline is a broad-spectrum second-generation tetracycline antibiotic used for the treatment of acne …
Matched Categories: … combinations of tetracyclines …

Methohexital

An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.
Approved
Matched Description: … An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia …
Matched Categories: … combinations of barbiturates …

Propyliodone

Radiopaque medium usually in oil; used in bronchography.
Approved
Matched Categories: … Diagnostic Uses of Chemicals …

Trimethobenzamide

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric...
Approved
Investigational
Matched Products: … Tigan(r) (trimethobenzamide Hydrochloride) …

Doxycycline

Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and...
Approved
Investigational
Vet approved
Matched Description: … [A174034] Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections …
Matched Categories: … combinations of tetracyclines …
Matched Products: … DOXYCYCLINE 100 MG FARMARS(R) …

Ferumoxides

Approved
Matched Categories: … Diagnostic Uses of Chemicals …

Bosutinib

Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR-ABL fusion protein.[A6902,A261796,A261801] The first BCR-ABL inhibitor,...
Approved
Matched Description: … [A6901,A17961] Bosutinib was first approved by the FDA in 2012 for the treatment of adult chronic, ... [L48436] On September 26, 2023, bosutinib was also approved by the FDA for the treatment of pediatric ... Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting …

Vosoritide

Achondroplasia is an autosomal dominant genetic disease and the most common cause of dwarfism in humans. It results from a gain-of-function missense mutation in FGFR3 that results in a dramatic suppression of bone growth, both in volume and in length.[A242273,A242277] Treatment for achondroplasia includes both surgical and pharmacological interventions, the...
Approved
Investigational
Matched Description: … suppression of bone growth, both in volume and in length. ... Achondroplasia is an autosomal dominant genetic disease and the most common cause of dwarfism in humans ... [A242277] It results from a gain-of-function missense mutation in _FGFR3_ that results in a dramatic …
Matched Categories: … Drugs for Treatment of Bone Diseases …

Lutetium Lu 177 dotatate

A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting tumours with molecules carrying radioactive particles that bind to specific receptors expressed by the tumour. Lutetium Lu 177 dotatate may also be referred to as...
Approved
Investigational
Matched Description: … The presence of a radioligand allows monitoring of treatment response post therapy and prior to next ... fraction of the dose delivery which may be clinically beneficial in estimating the intensity of lesion ... A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of …
Matched Categories: … Diagnostic Uses of Chemicals …

Zinc ascorbate

Approved
Nutraceutical
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …
Displaying drugs 2676 - 2700 of 9733 in total