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Displaying drugs 2701 - 2725 of 9713 in total

Gadoteridol

Gadoteridol is a macrocyclic nonionic gadolinium that provides contrast enhancement of the brain, spine, and surrounding tissues, resulting in improved visualization (compared with unenhanced MRI) of lesions with abnormal vascularity or those thought to disrupt the normal blood-brain barrier.[A263076,A263081,L49871] It was 1 of the 3 macrocyclic gadolinium-based contrast agents (GBCAs)...
Approved
Investigational
Matched Description: … Gadoteridol is a macrocyclic nonionic gadolinium that provides contrast enhancement of the brain, spine ... , and surrounding tissues, resulting in improved visualization (compared with unenhanced MRI) of lesions ... [A263076,A263081,L49871] It was 1 of the 3 macrocyclic gadolinium-based contrast agents (GBCAs) that …
Matched Categories: … Diagnostic Uses of Chemicals …

Dienestrol

Dienestrol is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist. Estrogens work partly by increasing a normal clear discharge from the vagina and making the vulva and urethra healthy. Using or applying an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness, or soreness of...
Approved
Investigational
Matched Description: … the vagina (atrophic vaginitis), and inflammation of the urethra (atrophic urethritis). ... an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness, or soreness of ... are treated with vaginal estrogens include a genital skin condition (vulvar atrophy), inflammation of …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Pyrazinamide

A pyrazine that is used therapeutically as an antitubercular agent.
Approved
Investigational
Matched Categories: … Drugs for Treatment of Tuberculosis …

Human Rho(D) immune globulin

Human Rho(D) immune globulin is a medicine given by intramuscular or intravenous injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Rho (D) immune globulin is available as a sterile, lyophilized or liquid gamma globulin (IgG) fraction containing antibodies to the...
Approved
Investigational
Matched Description: … injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of ... Immune globullin was purified via ion-exchange chromatography method and prepared from pools of human ... It was approved by FDA as treatment for suppression of rhesus (Rh) isoimmunization or chronic immune …
Matched Products: … RHOPHYLAC(R) 300 …

Ciclesonide

Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco.
Approved
Investigational
Matched Mixtures name: … DUESONIT 18/200 MCG INHALASYON ICIN TOZ ICEREN KAPSUL, 60 ADET ... DUESONIT 18/200 MCG INHALASYON ICIN TOZ ICEREN KAPSUL, 120 ADET ... DUESONIT 18/400 MCG INHALASYON ICIN TOZ ICEREN KAPSUL, 60 ADET …

Cycloserine

Antibiotic substance produced by Streptomyces garyphalus.
Approved
Matched Categories: … Drugs for Treatment of Tuberculosis …

Cyclothiazide

As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like cyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter....
Approved
Matched Description: … the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. ... reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of ... The antihypertensive mechanism of cyclothiazide is less well understood although it may be mediated through …
Matched Categories: … combinations of sulfonamides …

Dezocine

Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea.
Approved
Investigational
Matched Description: … when administered during outpatient laparoscopy, although is associated with an increased incidence of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Chloramphenicol succinate

Chloramphenicol succinate is an ester prodrug of chloramphenicol. Chloramphenicol is a bacteriostatic antibiotic. Use of chloramphenicol succinate and chloramphenicol has decreased due to the risk of potentially fatal blood dyscrasias. Chloramphenicol succinate was granted FDA approval on 20 February 1959.
Approved
Matched Description: … [A204065] Use of chloramphenicol succinate and chloramphenicol has decreased due to the risk of potentially ... Chloramphenicol succinate is an ester prodrug of [chloramphenicol]. …

Phenytoin

Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as...
Approved
Vet approved
Matched Description: … Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of ... [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market. …
Matched Categories: … Inducers of Drug Clearance ... Metabolic Side Effects of Drugs and Substances …
Matched Products: … EPAMIN(R) SUSPENSION …

Norfloxacin

A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Approved
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Matched Products: … URIGEN(R)TABLETAS 400 MG …

Medrogestone

Medrogestone (INN), also known as 6,17α-dimethyl-6-dehydroprogesterone, is a progestational agent derived from 17-methylprogesterone. It was conceived as an alternative for an orally effective contraceptive option. It was developed by Ayerst, approved in Canada in 1969 and its current status is cancelled post-marketing. It was never approved by the FDA.
Approved
Withdrawn
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Acetyl sulfisoxazole

Sulfisoxazole acetyl is an ester of sulfisoxazole, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity. Sulfisoxazole acetyl competes with PABA for the bacterial enzyme, dihydropteroate synthase, preventing the incorporation of PABA into dihydrofolic acid, which is the precursor of folic acid. This process causes...
Approved
Vet approved
Matched Description: … This process causes an inhibition of bacterial folic acid synthesis and de novo synthesis of purines ... of para-aminobenzoic acid (PABA) with antibacterial activity. ... PABA into dihydrofolic acid, which is the precursor of folic acid. …
Matched Categories: … combinations of sulfonamides …

Ribavirin

Producing a broad-spectrum activity against several RNA and DNA viruses, Ribavirin is a synthetic guanosine nucleoside and antiviral agent that interferes with the synthesis of viral mRNA. It is primarily indicated for use in treating hepatitis C and viral hemorrhagic fevers. HCV is a single-stranded RNA virus that is categorized...
Approved
Matched Description: … Combination therapy of ribavirin and [DB00008] results in the SVR of 44% in patients with genotype 1 ... Additionally, including ribavirin in the regimen can increase the risk of anemia. ... Ribavirin is a synthetic guanosine nucleoside and antiviral agent that interferes with the synthesis of …
Matched Mixtures name: … Rebetron Solution (albumin (human) Free) (18 Miu Multi-dose Pen / 200mg Capsules) …
Matched Categories: … Antivirals for treatment of HCV infections …

Prasugrel

Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversibly binds to P2Y12 type ADP receptors on platelets thus preventing...
Approved
Matched Description: … R-138727 irreversibly binds to P2Y12 type ADP receptors on platelets thus preventing activation of the ... As a result, inhibition of ADP-mediated platelet activation and aggregation occurs. ... prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R- …

Metoprolol

Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative. To this date,...
Approved
Investigational
Matched Description: … [A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic ... bioavailability of the succinate derivative. ... commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of …
Matched Products: … LOPRESOR R ... CARDOXONE 200 R. ... Metoprolol Succinate E/r …

Pseudoephedrine

Pseudoephedrine is structurally related to ephedrine but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseudoephedrine was described...
Approved
Matched Description: … [A188823] The decongestant effect of pseudoephedrine was described in dogs in 1927.[A188823] ... [A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional …
Matched Mixtures name: … DOSITAN (R) TABLETAS ... Regular Strength Cold Medication(daytime R.) ... FLURINOL(R) D COMPRIMIDOS DE LIBERACION MODIFICADA …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Codeine

The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease...
Approved
Illicit
Matched Iupac: … 13R,14S,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18 …
Matched Description: … The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for ... increasing the ability of patients to engage in day to day activities. …
Matched Mixtures name: … Acetaminophen, Caffeine, and 8mg Of Codeine Phosphate Tablets ... Acetaminophen, Caffeine and 8 Mg Of Codeine Phosphate Tablets …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Butalbital

Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervous system (CNS) depression that ranges from...
Approved
Illicit
Matched Description: … [A177754] Butalbital has a low degree of selectivity and a narrow therapeutic index. ... Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens ... It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety …
Matched Categories: … combinations of barbiturates …

Diethylpropion

A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)
Approved
Illicit
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Ioxitalamic acid

Ioxitalamate is an ionic iodinated contrast medium. It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of 1500-1800 mOsm/kg. Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem Canada Inc and approved by Health Canada in 1995. Until the...
Approved
Matched Description: … [A27209] It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of ... [A33006] Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem …
Matched Categories: … Diagnostic Uses of Chemicals …

Tryptophan

An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit...
Approved
Nutraceutical
Withdrawn
Matched Description: … It is a precursor of indole alkaloids in plants. ... It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). …
Matched Mixtures name: … Vamin 18 Electrolyte-free ... VAMIN 18 EF AMINOASIT SOLÜSYONU, 500 ML ... VAMIN 18 EF AMINOASIT SOLÜSYONU, 1000 ML …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Silver sulfadiazine

Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns.
Approved
Vet approved
Matched Categories: … combinations of sulfonamides …

Gadoxetic acid

Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug. Gadoxetate is a...
Approved
Matched Description: … contrast of enhancement and therefore heightening the liver parenchyma-liver tumours contrast. ... anion-transporting polypeptides (OATPs) and liver tumor cells lack OATPs, liver tumors show a lack of …
Matched Categories: … Diagnostic Uses of Chemicals …

Tedizolid phosphate

Drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus penumoniae, represent a massive public health threat.[A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the previously approved linezolid and is generally effective against multidrug-resistant Gram-positive bacteria. Tedizolid is indicated for the...
Approved
Matched Description: … [A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the ... Tedizolid is indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Displaying drugs 2701 - 2725 of 9713 in total