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Displaying drugs 2776 - 2800 of 9573 in total

Echinacea purpurea

Approved
Experimental

Thioridazine

A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed,...
Approved
Withdrawn
Matched Description: … Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal ... control of severely disturbed or agitated behavior. ... A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Glecaprevir

Glecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication. In combination with DB13878, glecaprevir is a useful therapy for patients who experienced therapeutic failure from other NS3/4A protease inhibitors. It demonstrates a high genetic barrier against resistance...
Approved
Investigational
Matched Description: … treatment, of ≥93% across genotypes 1a, 2a, 3a, 4, 5 and 6 [FDA Label]. ... It demonstrates a high genetic barrier against resistance mutations of the virus. ... The combinations of amino acid substitutions at NS3 position Y65H and D/Q168 also results in greater …
Matched Categories: … Antivirals for treatment of HCV infections …

Paliperidone

Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin...
Approved
Matched Description: … the other effects of the drug. ... Paliperidone is the primary active metabolite of risperidone. ... The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Risperidone

Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. Paliperidone, another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone). Schizophrenia and...
Approved
Investigational
Matched Description: … Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of ... [L12885] It is one of the most widely used SGAs. ... Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Products: … ISPERIN(R)FAST 0.5 MG ... RISPERDAL CONSTA (R) 50 MG ... ISPERIN(R)FAST 2 MG TABLETA ORODISPERSABLE …

Cisapride

In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients.
Approved
Investigational
Withdrawn
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Phenelzine

Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name of Nardil.
Approved
Matched Description: … It is currently approved under prescription by the name of Nardil. ... β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Theophylline

A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly...
Approved
Matched Categories: … combinations of xanthines …
Matched Products: … TEOFILINA R ® 200 MG ... TEOFILINA R CAPSULAS 100 MG ... DIFFUMAL R 200 MG TABLET, 30 ADET …

Dihydroergotamine

A 9,10alpha-dihydro derivative of ergotamine. Dihydroergotamine is used as an abortive therapy for migraines. Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Recent improvements have been made in the design of intranasal delivery devices allowing...
Approved
Investigational
Matched Description: … 3-fold in Cmax and 4-fold in AUC despite the solution formulated at 75% of the strength of the existing ... A 9,10alpha-dihydro derivative of [ergotamine]. ... delivery of dihydroergotamine solution to the vasculature-rich upper nasal cavity. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Trimethoprim

Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in combination with sulfamethoxazole due to their...
Approved
Vet approved
Matched Description: … that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of ... tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately ... complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of …
Matched Mixtures name: … SOLASTEM(R) TABLETAS ... MEDIPRIM F (R) TABLETA ... MEDIPRIM F (R) TABLETA …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Rifabutin

A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.
Approved
Investigational
Matched Categories: … Drugs for Treatment of Tuberculosis …

Primidone

Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954.
Approved
Vet approved
Matched Categories: … combinations of barbiturates …

Rubidium

Approved
Investigational

Ramipril

Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII)....
Approved
Matched Synonyms: … (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta …
Matched Description: … Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin ... reduce the rate of death, myocardial infarction and stroke in individuals at high risk of cardiovascular ... Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications …

Red pepper

Red pepper allergenic extract is used in allergenic testing.
Approved

Amprenavir

Amprenavir is a protease inhibitor used to treat HIV infection.
Approved
Investigational
Matched Categories: … Drugs for Treatment of Tuberculosis …

Asenapine

Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use....
Approved
Matched Description: … Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Celecoxib

Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in...
Approved
Investigational
Matched Description: … [A181544] It is used to manage symptoms of various types of arthritis pain and in familial adenomatous ... ) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of ... evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of …
Matched Categories: … combinations of sulfonamides …

Ciprofloxacin

Ciprofloxacin is a second generation fluoroquinolone that has spawned many derivative antibiotics. It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of bacterial infections.[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] The first ciprofloxacin containing product was FDA approved on 22 October 1987.
Approved
Investigational
Matched Description: … is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Matched Products: … CIPROBAY(R) 500 ... CIPROBAY (R) (250) ... CINEPRIDE(R) 500 MG TABLETAS …

Buprenorphine

Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist used for the treatment of severe pain.[A186283,A186292] It is also commonly used as an alternative to methadone for the treatment of severe opioid addiction. Buprenorphine is commercially available as the brand name product Suboxone which is...
Approved
Illicit
Investigational
Vet approved
Matched Description: … agent for the treatment of conditions requiring high doses of strong opioids. ... Provision of OAT is often combined with education about harm reduction including use of clean needles ... The intention of substitution of illicit opioids with the long-acting opioids used in OAT is to prevent …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Clarithromycin

Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug...
Approved
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Matched Products: … KLACID (R) MR …

Quetiapine

Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high...
Approved
Matched Description: … [L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Products: … QUETIAMET(R) 25 MG TABLETA RECUBIERTA …

Methotrimeprazine

A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
Approved
Investigational
Matched Description: … effects resembling those of chlorpromazine. ... A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine ... It has the histamine-antagonist properties of the antihistamines together with central nervous system …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Rimexolone

Rimexolone is a 1% eye drop solution is a glucocorticoid steroid. It is used to treat inflammation in the eye. It is marketed as Vexol.
Approved

Chondroitin sulfate

Chondroitin sulfate is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA). The SYSADOA status suggested a pain relief and increased joint mobility after a relative long regular administration, as well as a long-lasting effect after the end of the treatment. Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine...
Approved
Investigational
Nutraceutical
Matched Description: … Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine and 1,4-β-d-glucuronic ... mobility after a relative long regular administration, as well as a long-lasting effect after the end of ... acid units which bear 4-O- and/or 6-O-sulfations at the N-acetylgalactosamine units disposed of in specific …
Matched Mixtures name: … ARTROFORT(R) COMPLEX …
Displaying drugs 2776 - 2800 of 9573 in total