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Displaying drugs 2801 - 2825 of 9732 in total

Etravirine

Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 100mg tablets in the treatment of...
Approved
Matched Description: … On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 100mg tablets in ... On March 26, 2012, approval was extended for use in treatment-experienced pediatric patients 6 to 18 ... of rashes in patients taking etravirine, lead to a modification of etravirine's monograph. …

Ganaxolone

Ganaxolone is the 3β-methylated synthetic analog of allopregnanolone, a metabolite of progesterone. Ganaxolone belongs to a class of compounds referred to as neurosteroids. Endogenous neurosteroids, which comprise certain metabolites of progesterone and deoxycorticosterone, bind potently and specifically to GABAA receptors to enhance their inhibitory effects, and are thus known to...
Approved
Investigational
Matched Description: … Ganaxolone is the 3β-methylated synthetic analog of [allopregnanolone],[L41130] a metabolite of [progesterone ... [A3197] Ganaxolone belongs to a class of compounds referred to as neurosteroids. ... [L41130] It was approved under the brand name ZTALMY by the US FDA in March 2022 for the treatment of …

Fesoterodine

Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome.
Approved
Matched Description: … Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. …

Bretylium

Bretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. The primary mode of action for bretylium is thought to be inhibition of voltage-gated K(+) channels. Recent evidence...
Approved
Matched Description: … The primary mode of action for bretylium is thought to be inhibition of voltage-gated K(+) channels. ... Bretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is ... used in emergency medicine, cardiology, and other specialties for the acute management of ventricular …

Elagolix

Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the first and only...
Approved
Investigational
Matched Description: … As of 24 July 2018, however, the U.S. ... Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis ... It has been determined that endometriosis is one of the most common gynecologic disorders in the United …

Flibanserin

Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder...
Approved
Investigational
Matched Description: … It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of ... Flibanserin's mechanism of action is attributed to its high affinity for 5-HTA1 and 5-HTA2 receptors, ... displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Ciprofloxacin

Ciprofloxacin is a second generation fluoroquinolone that has spawned many derivative antibiotics. It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of bacterial infections.[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] The first ciprofloxacin containing product was FDA approved on 22 October 1987.
Approved
Investigational
Matched Description: … is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Matched Products: … CIPROBAY(R) 500 ... CIPROBAY (R) (250) ... CINEPRIDE(R) 500 MG TABLETAS …

Trimebutine

Trimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects. It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility disorders, with IBS being one of the most common multifactorial GI...
Approved
Matched Description: … disorders, with IBS being one of the most common multifactorial GI disorders [A19691]. ... It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility …
Matched Products: … BUMETIN(R) TABLETASRETARD 300MG …

Tocofersolan

D-Alpha-tocopheryl polyethylene glycol 1000 succinate (Tocofersolan, Vedrop), has been developed in Europe as an orally bioavailable source of vitamin E in children suffering from cholestasis . Cholestasis is the reduction or stoppage of bile flow, either to impaired secretion by hepatocytes (liver cells) or obstruction , . Tocofersolan is a...
Approved
Matched Description: … of [DB11251]. ... 1000 succinate (Tocofersolan, Vedrop), has been developed in Europe as an orally bioavailable source of ... Cholestasis is the reduction or stoppage of bile flow, either to impaired secretion by _hepatocytes_ …

Benzydamine

Benzydamine (also known as Tantum Verde or Difflam), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties. It is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal system. Although the indazole analogue benzydamine is a...
Approved
Matched Description: … it has various physicochemical properties and pharmacologic activities that are different from those of ... It is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal ... traditional aspirin-like NSAIDs but facilitate benzydamine's mechanism of action as an effective locally-acting …
Matched Mixtures name: … TANTUM VERDE DUO 22,5 MG+18 MG/15 ML GARGARA ... TANTUM VERDE DUO FORTE 45 MG+18 MG/15 ML GARGARA …

Piracetam

Piracetam is a nootropic drug in the racetams group, with chemical name 2-oxo-1-pyrrolidine acetamide. It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative of the neurotransmitter γ-aminobutyric acid (GABA). However its mechanism of action differ from that of endogenous GABA. Piracetam has neuroprotective and...
Approved
Investigational
Matched Description: … However its mechanism of action differ from that of endogenous GABA. ... shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative of …

Bimekizumab

Bimekizumab is a humanized monoclonal antibody directed towards IL-17, which was approved for use in the EU on August 20, 2021, for the treatment of plaque psoriasis.[L39665,L39680] It is the first IL-17 inhibitor to target both IL-17A and IL-17F. It has demonstrated superior efficacy as compared to another IL-17 inhibitor,...
Approved
Investigational
Matched Description: … Bimekizumab was also granted FDA approval on October 18, 2023.[L48551] ... directed towards IL-17, which was approved for use in the EU on August 20, 2021, for the treatment of ... as well as [ustekinumab] (an IL-12/23 inhibitor) and [adalimumab] (a TNF inhibitor) in the treatment of …

Nefazodone

Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with...
Approved
Withdrawn
Matched Description: … On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States. ... Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) ... Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Cinchocaine

A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
Approved
Vet approved
Matched Description: … It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is ... A local anesthetic of the amide type now generally used for surface anesthesia. …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Thiamylal

A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)
Approved
Vet approved
Matched Description: … A barbiturate that is administered intravenously for the production of complete anesthesia of short duration ... , for the induction of general anesthesia, or for inducing a hypnotic state. …
Matched Categories: … combinations of barbiturates …

Dexfenfluramine

Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.
Approved
Illicit
Investigational
Withdrawn
Matched Description: … However, following multiple concerns about the cardiovascular side-effects of the drug, such approval ... For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Lithium carbonate

Lithium has been used to treat manic episodes since the 19th century . Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label].
Approved
Matched Description: … Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651, …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Enasidenib

Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of adult patients with AML [A20344, A20345]. Patients eligible for this treatment...
Approved
Investigational
Matched Description: … Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory ... This small molecule acts as an allosteric inhibitor of mutant IDH2 enzyme to prevent cell growth, and ... Patients eligible for this treatment are selected by testing the presence of IDH2 mutations in the blood …

Sitagliptin

Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar[FDA label,A2255]....
Approved
Investigational
Matched Description: … to improve control of blood sugar[FDA label,A2255]. ... The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon …
Matched Mixtures name: … SIPTATINMET R …

Lactulose

Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929 , investigations regarding its possible use as a laxative for...
Approved
Matched Description: … Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative ... synthesized in 1929[A178081], investigations regarding its possible use as a laxative for the treatment of ... Essential Medicines as one of the most effective and safe medicines employed in a health system[L6205 …
Matched Products: … Comalose R Sirop 10gm/15ml …

Sulfamethizole

A sulfathiazole antibacterial agent.
Approved
Investigational
Vet approved
Matched Categories: … combinations of sulfonamides …

Zotepine

Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany since 1980's. Zotepine was never approved by the FDA. In 1993,...
Approved
Investigational
Withdrawn
Matched Description: … inactive drug substance (Status I, Type II) and in 1995 the FDA studied the manufacturing procedures of ... In the EMA, by 2015 it was under pharmacovigilance studies for the potential treatment of acute renal ... [L1082] When the analysis of antipsychotics was retaken in 2016 by the FDA, zotepine did not reach the …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Pibrentasvir

Pibrentasvir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS5A inhibitor that targets the the viral RNA replication and viron assembly. In combination with DB13879, pibrentastiv is a useful therapy for patients who experienced therapeutic failure from other NS5A inhibitors. In cell cultures, the emergence of amino...
Approved
Investigational
Matched Description: … treatment, of ≥93% across genotypes 1a, 2a, 3a, 4, 5 and 6 [FDA Label]. ... In cell cultures, the emergence of amino acid substitutions at known NS5A inhibitor resistance-associated ... The ultimate goal of the combination treatment is to achieve sustained virologic response (SVR) and cure …
Matched Categories: … Antivirals for treatment of HCV infections …

Alfentanil

A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Approved
Illicit
Matched Description: … A short-acting opioid anesthetic and analgesic derivative of fentanyl. ... It produces an early peak analgesic effect and fast recovery of consciousness. ... Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Amantadine

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and...
Approved
Matched Description: … in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. ... An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. ... The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Displaying drugs 2801 - 2825 of 9732 in total