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Displaying drugs 276 - 300 of 15057 in total

Galcanezumab

Galcanezumab is a humanized monoclonal antibody developed by Eli Lilly and Company against human calcitonin gene-related peptide (CGRP). Although several small-molecule CGRP receptor antagonists have been developed, humanized monoclonal antibodies like galcanezumab are specifically designed to selectively bind to CGRP entities with high potency. Given this target specificity, lack of...
Approved
Investigational
Matched Description: … A pregnancy exposure registry has been established to evaluate the safety of this drug in pregnant women ... Galcanezumab is a humanized monoclonal antibody developed by Eli Lilly and Company against human calcitonin ... gene-related peptide (CGRP). …
Matched Categories: … Calcitonin Gene-Related Peptide (CGRP) Antagonists ... Calcitonin Gene-Related Peptide Receptor Antagonists …
Matched Products: … EMGALITY SOLUTION FOR INJECTION IN PRE-FILLED PEN 120 MG/ML ... Pontevia 120 mg solution for injection in pre-filled pen ... Pontevia 120 mg solution for injection in pre-filled syringe …

Aflibercept

Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It...
Approved
Matched Description: … [A261130] Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 ... as an intravenous injection for the treatment of metastatic colorectal cancer, and it was approved by ... [L47966,L47971] The intravitreal formulation, under the brand name EYELEA, was approved by the FDA for …
Matched Products: … EYLEA 40MG/ML SOLUTION FOR INJECTION IN VIAL ... EYLEA SOLUTION FOR INJECTION IN VIAL 2MG ... EYLEA SOLUTION FOR INJECTION IN PREFILLED SYRINGE 2MG …

Tolazamide

A sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Approved
Investigational
Matched Synonyms: … 4-(p-Tolylsulfonyl)-1,1-hexamethylenesemicarbazide …
Matched Iupac: … 1-(azepan-1-yl)-3-(4-methylbenzenesulfonyl)urea …
Matched Description: … A sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide. …
Matched Categories: … Drugs Used in Diabetes …

Cinoxacin

Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections.
Approved
Investigational
Withdrawn
Matched Synonyms: … 1-ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3-carboxylic acid …
Matched Iupac: … 1-ethyl-4-oxo-1H,4H,7H-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid …
Matched Description: … Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections …

Perindopril

Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to...
Approved
Matched Description: … It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration ... Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor ... Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of …
Matched Mixtures name: … PERINDO/IN RAT T 5/1.25 ... PERINDO/IN RAT T 5/1.25 ... PERINDO IN 1A PHA4/1.25MG …
Matched Products: … HITEN 4 TABLETS 4 MG ... HITEN 4 (Perindopril tert-Butylamine Tablets 4 mg) ... Coversyl 4 mg …

Clomifene

A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Approved
Investigational
Matched Synonyms: … 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine …
Matched Iupac: … {2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]ethyl}diethylamine …
Matched Description: … A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the …

Octocrylene

Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin...
Approved
Investigational
Matched Description: … Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing ... dissipated by sunlight, and to minimize skin damage from prolonged sun exposure. ... Because of its effectiveness, the chemical has been approved across the globe for use in cosmetics and …
Matched Mixtures name: … Hope In A Jar SPF 25 ... Renewed Hope In A Jar SPF 30 ... Renewed Hope In A Jar SPF 30 …
Matched Products: … Panama Jack SPF 4 ... Panama Jack SPF 4 Dark Tanning Oil …

Mobocertinib

Mobocertinib is a kinase inhibitor targeted against human epidermal growth factor receptor (EGFR). It is used specifically in the treatment of non-small cell lung cancer (NSCLC) caused by exon 20 insertion mutations in the EGFR gene, which are typically associated with a poorer prognosis (as compared to "classical" EGFR mutants...
Approved
Investigational
Matched Iupac: … propan-2-yl 2-[(4-{[2-(dimethylamino)ethyl](methyl)amino}-2-methoxy-5-(prop-2-enamido)phenyl)amino]-4 …
Matched Description: … mutations in the _EGFR_ gene,[L38368] which are typically associated with a poorer prognosis (as compared ... It is used specifically in the treatment of non-small cell lung cancer (NSCLC) caused by exon 20 insertion ... Mobocertinib is a kinase inhibitor targeted against human epidermal growth factor receptor (EGFR). …

Carbimazole

An imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity.
Approved
Investigational
Matched Products: … NEO MERCAZOLE …

Golodirsen

Golodirsen is a morpholino antisense oligomer designed to treat about 8% of patients with Duchenne Muscular Dystrophy (DMD). This is an X-linked condition leading to progressive muscle degeneration that begins in early childhood, rendering many patients wheelchair-bound by age 12. Often, patients succumb to this condition by age 30 or...
Approved
Matched Description: … [A188580,T756] A similar drug used in the treatment of other types of DMD is [eteplirsen], which targets ... December 12, 2019 due to the urgent need for this drug in patients suffering from a certain form of DMD ... , rendering many patients wheelchair-bound by age 12. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Padimate O

Padimate O is an active sunscreen agent in cosmetics and over-the-counter sunscreen drug products in concentrations up to 8%, as regulated by the FDA . It is a structurally-related compound to DB02362 that absorbs UV-B rays to prevent photodamage. It penetrates human skin, and is shown to induce non-ligatable strand...
Approved
Matched Iupac: … 2-ethylhexyl 4-(dimethylamino)benzoate …
Matched Description: … concentrations up to 8%, as regulated by the FDA [L2153]. ... Padimate O is an active sunscreen agent in cosmetics and over-the-counter sunscreen drug products in ... It is a structurally-related compound to [DB02362] that absorbs UV-B rays to prevent photodamage. …
Matched Mixtures name: … Ulta Tanning SPF 4 ... Kroger SPF 4 Tanning Oil ... Meijer SPF 4 Tanning Oil …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Lip Balm Sunscreen SPF 4 Original ... Cap Soleil: Lait Solaire Fps 4 ... Lotion Solaire Hydratante Fps 4 …

Benzoic acid

A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amino acids. This leads...
Approved
Investigational
Matched Description: … This leads to excretion of these amino acids and a decrease in ammonia levels. ... Total Positive and Negative Syndrome Scale scores dropped by 21% compared to placebo. ... A fungistatic compound that is widely used as a food preservative. …
Matched Mixtures name: … NEO BOROCILLINA ... NEO BOROCILLINA ... NEO BOROCILLINA …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … S Panax All In One Mist …

Cyclacillin

A cyclohexylamido analog of penicillanic acid.
Approved
Matched Synonyms: … (2S,5R,6R)-6-{[(1-aminocyclohexyl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane …
Matched Iupac: … (2S,5R,6R)-6-(1-aminocyclohexaneamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic …
Matched Description: … A cyclohexylamido analog of penicillanic acid. …

Hydroxocobalamin

Hydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is an injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency. It is also used in cyanide poisoning, Leber's optic atrophy, and toxic amblyopia.
Approved
Matched Description: … It is also used in cyanide poisoning, Leber's optic atrophy, and toxic amblyopia. …
Matched Categories: … Heterocyclic Compounds with 4 or More Rings …
Matched Products: … NEO CYTAMEN …

Estradiol valerate

Estradiol Valerate (also known as E2V) is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol acetate therefore...
Approved
Investigational
Vet approved
Matched Iupac: … (1S,3aS,3bR,9bS,11aS)-7-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Because of the difference in potency between estradiol and estrone, menopause (and a change in primary ... by the adrenal cortex, to estrone by peripheral tissues. ... Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol …
Matched Mixtures name: … Neo Pause Injection …
Matched Products: … Neo-diol Inj 20mg/ml …

Lovastatin

Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of Aspergillus terreus. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid...
Approved
Investigational
Matched Synonyms: … (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran …
Matched Iupac: … (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen …
Matched Description: … a sequence of metabolic reactions involved in the production of several compounds involved in lipid ... clinical studies to result in a 45.8% to 54.6% decrease in LDL cholesterol levels, while lovastatin ... medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by …

Sulfathiazole

Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination with sulfabenzamide and sulfacetamide. Except for those formulated for vaginal use, the FDA withdrew its approval for the use of...
Approved
Vet approved
Withdrawn
Matched Synonyms: … 4-Amino-N-2-thiazolylbenzenesulfonamide …
Matched Iupac: … 4-amino-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide …
Matched Description: … Sulfathiazole is a short-acting sulfa drug. ... It is still occasionally used, sometimes in combination with sulfabenzamide and sulfacetamide. ... It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. …

Zinc

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with anemia, short stature, hypogonadism, impaired wound...
Approved
Investigational
Matched Description: … It is identified by the symbol _Zn_ [L2098]. ... It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an ... as a marker of these diseases [L2097]. …
Matched Mixtures name: … Zinc Lozenges With Vitamin C In A Nonmedicinal Base With Echinacea Lozenge ... Mte 4 Inj ... Formula-4 Sx …
Matched Products: … Port A Mins Super Zinc 15 ... Port A Mins Super Zinc 30 …

Ixekizumab

Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflammatory conditions. In particular, IL-17A has...
Approved
Investigational
Matched Description: … Ixekizumab is produced by recombinant DNA technology in a recombinant mammalian cell line and purified ... Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin ... In particular, IL-17A has been found to be implicated in a variety of autoimmune diseases including Rheumatoid …
Matched Products: … Taltz 80mg solution for injection in pre-filled pen ... Taltz 80mg solution for injection in pre-filled syringe ... TALTZ SOLUTION FOR INJECTION IN PRE-FILLED PEN 80 mg/ml …

Baricitinib

Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated inflammation and immune responses. Baricitinib was...
Approved
Investigational
Matched Iupac: … 2-[1-(ethanesulfonyl)-3-(4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)azetidin-3-yl]acetonitrile …
Matched Description: … of rheumatoid arthritis in adults [A248395] and was later approved by the FDA in 2018. ... [A248405] While baricitinib was granted emergency use as a treatment for COVID-19 in combination with ... Baricitinib is a Janus kinase (JAK) inhibitor. …
Matched Categories: … MATE 2 Substrates with a Narrow Therapeutic Index ... OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Products: … โอลูเมียนท์ (4 มก.) ... UNAMİTY 4 MG FİLM KAPLI TABLET, 7 ADET ... UNAMİTY 4 MG FİLM KAPLI TABLET, 14 ADET …

Meticillin

One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.
Approved
Investigational
Matched Synonyms: … (2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic …
Matched Iupac: … (2S,5R,6R)-6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic …
Matched Description: … It is inactivated by gastric acid so administered by injection. ... One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein …

Adalimumab

Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor.[A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. This drug is frequently known as Humira. It is produced...
Approved
Experimental
Matched Description: … [A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. ... It is produced by recombinant DNA technology using a mammalian cell expression system. ... Adalimumab-atto was the first adalimumab biosimilar approved by the FDA in 2016. …
Matched Products: … HULIO 40MG ILO IN FER ... AMGEVITA 40 mg/0.8 ml solution for injection in pre-filled syringe ... IDACIO SOLUTION FOR INJECTION IN PRE-FILLED PEN 40MG/0.8ML …

Evolocumab

Evolocumab is a monoclonal antibody designed for the treatment of hyperlipidemia by Amgen. It is a subcutaneous injection approved by the FDA for individuals on maximum statin therapy who still require additional LDL-cholesterol lowering. It is approved for both homozygous and heterozygous familial cholesterolemia as an adjunct to other first-line...
Approved
Matched Description: … Evolocumab is a monoclonal antibody designed for the treatment of hyperlipidemia by Amgen. ... It is a subcutaneous injection approved by the FDA for individuals on maximum statin therapy who still ... designed to bind to PCSK9 and inhibit PCSK9 from binding to LDL receptors on the liver surface, resulting in …
Matched Products: … REPATHA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 140MG/ML ... Repatha Solution for Injection in Pre-filled Syringe 140mg/mL (evolocumab) ... REPATHA SOLUTION FOR INJECTION IN PRE-FILLED AUTOINJECTOR 140MG/ML …

Tick-borne encephalitis vaccine (whole virus, inactivated)

Tick-borne encephalitis (TBE) is a disease caused by the TBE virus (TBEV), transmitted by ticks from the genus Ixodes. The disease course is variable. Some patients will be asymptomatic or experience a mild febrile illness, while others will experience the full course including neurological symptoms. TBE often manifests in a...
Approved
Matched Description: … by a variable asymptomatic period and then a second phase characterized by various neurological symptoms ... Tick-borne encephalitis (TBE) is a disease caused by the TBE virus (TBEV), transmitted by ticks from ... [A237505] TBE often manifests in a biphasic manner, with patients experiencing a flu-like illness followed …
Matched Products: … FSME-Immun 0,25 ml Junior Injektionssuspension in einer Fertigspritze ... FSME-Immun 0,5 ml Erwachsene Injektionssuspension in einer Fertigspritze …

Ethotoin

Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread...
Approved
Matched Synonyms: … 1-ethyl-2,5-dioxo-4-phenylimidazolidine …
Matched Description: … Ethotoin is a hydantoin derivative and anticonvulsant. …
Displaying drugs 276 - 300 of 15057 in total