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Displaying drugs 326 - 350 of 10409 in total

Belzutifan

Belzutifan is an inhibitor of hypoxia-inducible factor 2α (HIF-2α) used in the treatment of von Hippel-Lindau (VHL) disease-associated cancers. The HIF-2α protein was first identified in the 1990s by researchers at UT Southwestern Medical Center as a key player in the growth of certain cancers. Initially considered to be undruggable,...
Approved
Investigational
Matched Description: … Belzutifan is an inhibitor of hypoxia-inducible factor 2α (HIF-2α) used in the treatment of von Hippel-Lindau …
Matched Categories: … Antineoplastic Agents ... Antineoplastic and Immunomodulating Agents …

Rotavirus vaccine

Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotarix is a live attenuated vaccine containing the...
Approved

Pizotifen

Pizotifen belongs to the class of antamines and is related to cyproheptadine. It is a potent serotonin and tryptamine antagonist that has been used for migraine prevention for many years. It exhibits weak anticholinergic, antihistamine, and antikinin actions in addition to sedative and appetite-stimulating properties . Some patients receiving pizotifen...
Approved
Matched Description: … Sandomigran is available in a number of countries but is not approved by the FDA nor EMA. ... Pizotifen hydrochloride is an active ingredient in Sandomigran, which is used for the prophylactic management …
Matched Categories: … Antidepressive Agents ... Serotonin Agents ... Anticholinergic Agents ... Sensory System Agents ... Neurotransmitter Agents …

Satralizumab

Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to tocilizumab, which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune inflammatory disorder of the central...
Approved
Matched Description: … [A218551] It received subsequent approvals in Switzerland and Japan,[A218551] and was approved for use ... Satralizumab was first approved for use in Canada in June 2020 for the treatment of AQP4 antibody-positive ... receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an …
Matched Categories: … Immunosuppressive Agents ... Antineoplastic and Immunomodulating Agents …

Acetylcysteine

Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of acetaminophen overdose.[L31378,L31383,L31388,L31478] Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.[A228158,A228163,A228168] Acetylcysteine was granted FDA approval on 14 September 1963.
Approved
Investigational
Matched Description: … Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment …
Matched Categories: … Protective Agents ... Respiratory System Agents …
Matched Products: … Truemed Group LLC …

Diroximel fumarate

Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting forms of MS...
Approved
Investigational
Matched Description: … Diroximel fumarate was formulated by Alkermes in collaboration with Biogen, and was approved by the FDA …
Matched Categories: … Hepatotoxic Agents ... Immunosuppressive Agents ... Antineoplastic and Immunomodulating Agents …

Collagenase clostridium histolyticum

Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ulcers. On July 6,...
Approved
Investigational
Matched Description: … Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. ... [L14912] On July 6, 2020 a combination of injectable bacterial collagenases was approved by the FDA ... [L14872] Also known as Qwo, this injection is the first approved injectable treatment for cellulite and …
Matched Categories: … Skin and Mucous Membrane Agents …

Oxetacaine

Oxetacaine, also called oxethazaince, is a potent surface analgesic with the molecular formula N, N-bis-(N-methyl-N-phenyl-t-butyl-acetamide)-beta-hydroxyethylamine that conserves its unionized form at low pH levels. Its actions have shown to relieve dysphagia, relieve pain due to reflux, chronic gastritis, and duodenal ulcer. Oxetacaine is approved by Health Canada since 1995 for...
Approved
Investigational
Matched Description: … [A33104] Oxetacaine is approved by Health Canada since 1995 for its use as an antacid combination in ... [L1113] It is also in the list of approved derivatives of herbal products by the EMA.[L2816] …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Dalfopristin

Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis.
Approved
Matched Categories: … Anti-Bacterial Agents ... Anti-Infective Agents …

Benzphetamine

A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)
Approved
Illicit
Matched Categories: … Antidepressive Agents ... Adrenergic Agents ... Autonomic Agents ... Dopamine Agents ... Neurotransmitter Agents …

Lidoflazine

Approved
Experimental
Matched Categories: … Antiarrhythmic agents ... Cardiovascular Agents ... Agents causing hyperkalemia ... Vasodilating Agents ... Bradycardia-Causing Agents …

Esmolol

Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. It works by blocking beta-adrenergic receptors in the heart, which leads to decreased...
Approved
Withdrawn
Matched Categories: … Adrenergic Agents ... Hypotensive Agents ... Antiarrhythmic agents ... Antihypertensive Agents ... QTc Prolonging Agents …

Fluspirilene

A long-acting injectable antipsychotic agent used for chronic schizophrenia.
Approved
Investigational
Matched Categories: … Antidepressive Agents ... Dopamine Agents ... Antiarrhythmic agents ... Antipsychotic Agents ... Serotonin Agents …

Citric acid

A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium-chelating ability. Citric acid is one of the active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA...
Approved
Nutraceutical
Vet approved
Matched Description: … It is an acid compound found in citrus fruits. ... Citric acid is one of the active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved ... [L14120] It is also used in combination with magnesium oxide to form magnesium citrate, an osmotic laxative …
Matched Categories: … Chelating Agents ... Hematologic Agents ... Sequestering Agents ... Calcium Chelating Agents ... Urinary Acidifying Agents …

Methocarbamol

Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether. Methocarbamol tablets and intramuscular injections are prescription medicines indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of...
Approved
Vet approved
Matched Description: … [L6295] Methocarbamol was FDA approved on 16 July 1957.[L6265] ... [Label,L6268] In Canada, methocarbamol can be sold as an over the counter oral medicine at a lower dose ... Methocarbamol tablets and intramuscular injections are prescription medicines indicated in the United States as an …
Matched Categories: … Central Nervous System Agents ... Peripheral Nervous System Agents ... Muscle Relaxants, Centrally Acting Agents …

Pralsetinib

Pralsetinib, similar to the previously approved selpercatinib, is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small cell lung cancer. Although multikinase inhibitors, including cabozantinib, ponatinib,...
Approved
Investigational
Matched Description: … Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced …
Matched Categories: … Antineoplastic Agents ... Antineoplastic and Immunomodulating Agents …

Cyclobenzaprine

Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from Amitriptyline by only a single double bond.[A185039,A184982] Since its approval, it has...
Approved
Matched Description: … [A185039,A184982] Since its approval, it has remained relatively popular as an adjunctive, short-term …
Matched Categories: … Antidepressive Agents ... Serotonin Agents ... Neurotoxic agents ... Tranquilizing Agents ... Photosensitizing Agents …

Sertindole

Sertindole, a neuroleptic, is one of the newer antipsychotic medications available. Serdolect is developed by the Danish pharmaceutical company H. Lundbeck. It is a phenylindole derivative used in the treatment of schizophrenia. It was first marketed in 1996 in several European countries before being withdrawn two years later because of...
Approved
Investigational
Withdrawn
Matched Description: … It has once again been approved and should soon be available on the French and Australian market. …
Matched Categories: … Antidepressive Agents ... Antipsychotic Agents ... Neurotoxic agents ... Serotonin Agents ... Tranquilizing Agents …

Argatroban

Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients...
Approved
Investigational
Matched Categories: … Hematologic Agents …

Nortriptyline

Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA). It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.
Approved
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Tricyclic ... Antidepressive Agents Indicated for Depression ... Adrenergic Agents ... Serotonin Agents …

Pindolol

Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the early 1970s....
Approved
Investigational
Matched Categories: … Antidepressive Agents ... Adrenergic Agents ... Serotonin Agents ... Hypotensive Agents ... Cardiovascular Agents …

Flavin adenine dinucleotide

A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) Flavin adenine dinucleotide is approved for use in Japan under the trade name Adeflavin as an ophthalmic treatment for vitamin B2 deficiency.
Approved
Matched Description: … in Japan under the trade name Adeflavin as an ophthalmic treatment for vitamin B2 deficiency. ... (Lehninger, Principles of Biochemistry, 1982, p972) Flavin adenine dinucleotide is approved for use …

Relebactam

Relebactam is a diazabicyclooctane beta-lactamase inhibitor, similar in structure to avibactam.[A181195,A181207] It includes a piperidine ring which reduces export from bacterial cells by producing a positive charge. It is currently available in a combination product which includes imipenem and cilastatin to treat complicated urinary tract infections (UTIs), pyelonephritis, and complicated...
Approved
Investigational

Bezlotoxumab

Bezlotoxumab is a fully humanized ImmunoglobulinG1 (IgG1) kappa monoclonal antibody that binds to Clostridium difficile toxin B and neutralizes its effects. First approved by the FDA on October 21, 2016, bezlotoxumab is used to reduce the recurrence of C. difficile infection. On November 22, 2016, the Committee for Medicinal Products...
Approved
Investigational
Matched Description: … [L46976] First approved by the FDA on October 21, 2016,[A260106] bezlotoxumab is used to reduce the recurrence …

Digoxin Immune Fab (Ovine)

Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin derivative Digoxindicarboxymethylamine. It is used as an antidote for overdose of digoxin.
Approved
Matched Description: … It is used as an antidote for overdose of digoxin. …
Displaying drugs 326 - 350 of 10409 in total