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Displaying drugs 351 - 375 of 13884 in total

Vilazodone

Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. Vilazodone may also be associated with less sexual dysfunction and weight gain . Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Approved
Matched Description: … Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine …
Matched Categories: … Antidepressive Agents Indicated for Depression …

Ubrogepant

Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor...
Approved
Investigational
Matched Description: … Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. ... to as "gepants", have been investigated for migraines, but only ubrogepant and [rimegepant] remain in ... advance in migraine headache treatment and may become the new standard of therapy in the treatment of …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …

Dabrafenib

Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib),...
Approved
Investigational
Matched Description: … [L41955] In May 2018, Tafinlar (dabrafenib), in combination with Mekinist ([DB08911]), was approved ... Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK ... It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Brilliant green cation

Brilliant green, or ethanaminium, is a derivative of triarylmethane dye that has been used as a dye to color silk and wool. Due to its inhibitory actions against Gram positive microorganisms, brilliant green can be found in antiseptic products such as solutions and swabs used to prevent infection.
Approved
Vet approved
Matched Description: … Brilliant green, or ethanaminium, is a derivative of triarylmethane dye that has been used as a dye to ... Due to its inhibitory actions against Gram positive microorganisms, brilliant green can be found in antiseptic …
Matched Mixtures name: … Kerr 100 Triple Dye Dispos-A …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Golodirsen

Golodirsen is a morpholino antisense oligomer designed to treat about 8% of patients with Duchenne Muscular Dystrophy (DMD). This is an X-linked condition leading to progressive muscle degeneration that begins in early childhood, rendering many patients wheelchair-bound by age 12. Often, patients succumb to this condition by age 30 or...
Approved
Matched Description: … this drug in patients suffering from a certain form of DMD. ... [A188580,T756] A similar drug used in the treatment of other types of DMD is [eteplirsen], which targets ... a different genetic mutation. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Crotamiton

Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. It is a colorless to slightly yellowish oil, having a faint amine-like odor. It is miscible with alcohol and with methanol.
Approved
Matched Description: … Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use only ... It is a colorless to slightly yellowish oil, having a faint amine-like odor. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … A-Bite Cream …

Burosumab

Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic rickets . The U.S. Food and Drug Administration approved Crysvita (burosumab) in April 2018. This is the first drug approved...
Approved
Investigational
Matched Description: … X-linked hypophosphatemia causes low circulating levels of phosphorus in the blood. ... XLH is a serious disease which affects about 3,000 children and 12,000 adults in the United States. ... throughout a patient’s life [L2346]. …
Matched Categories: … Drugs for Treatment of Bone Diseases …
Matched Products: … CRYSVITA® SOLUTION FOR INJECTION 10 MG/ML ... CRYSVITA® SOLUTION FOR INJECTION 30 MG/ML ... CRYSVITA® SOLUTION FOR INJECTION 20 MG/ML …

Arbutamine

Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately .
Approved
Matched Description: … Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated ... to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in ... diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Ansuvimab

Infection with pathogenic filoviruses, such as Zaire ebolavirus (Ebola virus, EBOV), can cause severe hemorrhagic fever in humans, resulting in frequent outbreaks with case fatality rates as high as 90%.[A225933, A225938] Virtually all steps of the EBOV lifecycle have been targeted for therapeutic development. However, to date, the most successful...
Approved
Investigational
Matched Description: … [A225933, A225938] Virtually all steps of the EBOV lifecycle have been targeted for therapeutic development ... virus disease (EVD) in the Democratic Republic of Congo during a previous outbreak that began in 2018 ... to mediate EBOV endolysosomal escape, a key step in the EBOV lifecycle. …
Matched Categories: … Antiinfectives for Systemic Use ... Treatments for Ebola Virus Disease …

Procaine benzylpenicillin

Procaine benzylpenicillin (INN), also known as procaine G penicillin, is an injectable antiobiotic. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. Procaine benzylpenicillin is administered by deep intramuscular injection. It...
Approved
Vet approved
Matched Description: … Benzylpenicillin is active against a wide range of organisms and is the drug of first choice for many ... It is widely used in veterinary settings. ... (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. …
Matched Mixtures name: … Bicillin A-P Injection Pws …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Palovarotene

Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder. FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive heterotopic ossification, a process wherein connective tissues (e.g. skeletal muscle, ligaments, tendons) are replaced...
Approved
Investigational
Matched Description: … [A244920] Palovarotene was approved for use in Canada in January 2022 for the management of heterotopic ... interest in novel treatments for this disease. ... It first garnered interest as a potential treatment for emphysema but was eventually recognized as a …

Meclofenamic acid

A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
Approved
Vet approved
Matched Description: … A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. …
Matched Categories: … Topical Products for Joint and Muscular Pain ... Antiinflammatory Preparations, Non-Steroids for Topical Use …

Verapamil

Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs...
Approved
Matched Description: … Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, ... arrhythmias, and angina,[L8791] and was the first calcium channel antagonist to be introduced into therapy in ... [A188514] It is a member of the non-dihydropyridine class of calcium channel blockers, which includes …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …
Matched Products: … Isocor 2.5 mg/mL solution for injection or infusion …

Viloxazine

Viloxazine is a selective norepinephrine reuptake inhibitor. For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant. It was first approved in the UK in 1974; however, the immediate-release formulation was discontinued due to business reasons unrelated to drug safety and efficacy. In the US,...
Approved
Investigational
Withdrawn
Matched Description: … Viloxazine is a selective norepinephrine reuptake inhibitor. ... [L41685] For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant ... by the FDA for the treatment of attention deficit hyperactivity disorder (ADHD). …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates ... Monoamine Oxidase A Inhibitors …

Brexucabtagene autoleucel

Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as ibrutinib and acalabrutinib, the prognosis for MCL patients remains poor and those that relapse...
Approved
Matched Description: … of Bruton's tyrosine kinase (BTK) inhibitors such as [ibrutinib] and [acalabrutinib], the prognosis for ... method of T cell enrichment that decreases the prevalence of CD19-expressing tumour cells in the CAR ... [L15148] Brexucabtagene autoleucel was granted accelerated approval for the treatment of relapsed …

Mechlorethamine

A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval for the orphan...
Approved
Investigational
Matched Description: … It was formerly used as a war gas. ... in patients who have received prior skin-directed therapy. ... The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Ferrous gluconate

Approved
Matched Mixtures name: … Toni Com Liq ... Alsimine W Vitamins A D ... Multi-force for Women Tab …

Misoprostol

Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions.[L7616,L7619,A181589,A181583,A181697] The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the...
Approved
Matched Description: … , prevent post partum hemorrhage, and also for first trimester abortions. ... Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages ... gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the …
Matched Categories: … Drugs for Acid Related Disorders ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …

Beremagene geperpavec

Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector therapy. Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of wounds associated with dystrophic epidermolysis bullosa (DEB). DEB is caused by mutations in the COL7A1 gene that...
Approved
Matched Description: … [L46916] DEB is caused by mutations in the _COL7A1_ gene that encodes collagen VII (COL7), a major component ... [A259771] Beremagene geperpavec is genetically modified to deliver _COL7A1_, thereby restoring the levels ... of the anchoring fibrils for dermal–epidermal cohesion. …
Matched Categories: … Preparations for Treatment of Wounds and Ulcers …

Aluminum hydroxide

Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
Approved
Investigational
Matched Description: … It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. ... Subsequent increases in pH may inhibit the action of pepsin. ... An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. …
Matched Mixtures name: … Maalox oral suspension in sachet …
Matched Categories: … Drugs for Acid Related Disorders …

Patent Blue

Patent blue is aniline dye and it is one of the most common dyes used. It is a sodium or calcium salt of diethylammonium hydroxide inner salt. It has the chemical designation of (4-(alpha-(p-(diethylamino)phenyl)-2,4-disulfobenzylidene)-2,5-cyclohexadiene-1-ylidene)diethylammonium hydroxide. Patent blue was developed by Guerbet and approved by Health Canada on December 31, 1979....
Approved
Matched Description: … [L1113] The isomer isosulphan is used in the United States for the same indications than patent blue. ... [A32573] It is a sodium or calcium salt of diethylammonium hydroxide inner salt. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Mefenamic acid

A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
Approved
Matched Description: … A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties …

Chloroprocaine

Chloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride. Similar to other local anesthetics, it increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. The pharmacological profile of...
Approved
Investigational
Matched Description: … Similar to other local anesthetics, it increases the threshold for electrical excitation in nerves by ... methylparaben as a preservative. ... [A252952,L43382] Topical chloroprocaine for ophthalmic use was approved by the FDA in September 2022 …

Durvalumab

Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote normal immune responses that attack tumour...
Approved
Investigational
Matched Description: … [L12621] In September 2018, durvalumab was approved by the EMA for the treatment of adult patients with ... It was granted accelerated approval by the FDA in May 2017 [A192807] for the treatment of selected patients ... [A192789,L12627] On March 27, 2020, durvalumab was approved by the FDA for use in combination with [etoposide …
Matched Products: … IMFINZI CONCENTRATE FOR SOLUTION FOR INFUSION 50 MG/ML ... IMFINZI CONCENTRATE FOR SOLUTION FOR INTRAVENOUS INFUSION 50 MG/ML …

Ledipasvir

Ledipasvir is a direct acting antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most...
Approved
Matched Description: … In a joint recommendation published in 2016, the American Association for the Study of Liver Diseases ... being the most common in the United States, and affecting 72% of all chronic HCV patients [L852]. ... option in combination with [sofosbuvir] for the treatment of HCV genotypes 1a, 1b, 4, 5, and 6 [L852 …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use ... Treatments for Hepatitis C ... Antivirals for treatment of HCV infections …
Displaying drugs 351 - 375 of 13884 in total