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Displaying drugs 401 - 425 of 9223 in total

Dimethyl sulfoxide

A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including...
Approved
Vet approved
Matched Description: … of pharmaceuticals. ... Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application ... Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation …

Nisoldipine

Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone...
Approved
Matched Description: … Nisoldipine may be used in alone or in combination with other agents in the management of hypertension ... By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth …

Didanosine

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral...
Approved
Matched Description: … of nucleic acid chains. ... Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding ... This modification prevents the formation of phosphodiester linkages which are needed for the completion …
Matched Products: … VIDEN TABLETAS MASTICABLES 10 MG ... DIDANOSINA TABLETAS MASTICABLES 10 MG …

Plecanatide

Plecanatide is a drug approved in January 2017 by the FDA for the treatment of chronic idiopathic constipation (CIC). It should not be used in children less than six years of age, and should be avoided in patients six years to 18 years of age
Approved
Investigational
Matched Iupac: … methylbutyl]-C-hydroxycarbonimidoyl}-22-(2-carboxyethyl)-3,6,9,12,15,18,21,24,30,33,36-undecahydroxy-10 …
Matched Description: … to 18 years of age ... Plecanatide is a drug approved in January 2017 by the FDA for the treatment of chronic idiopathic constipation ... It should not be used in children less than six years of age, and should be avoided in patients six years …

Carprofen

Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. Carprofen was previously used in human medicine for over 10 years (1985-1995). It was generally well tolerated, with the majority of adverse effects being mild,...
Approved
Vet approved
Withdrawn
Matched Description: … Carprofen was previously used in human medicine for over 10 years (1985-1995). ... anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of ... It was generally well tolerated, with the majority of adverse effects being mild, such as gastro-intestinal …

Cetrorelix

Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not...
Approved
Investigational
Matched Description: … Cetrorelix does not allow the premature release of these eggs to occur. ... Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). …

Tacrolimus

Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis...
Approved
Investigational
Matched Iupac: … 18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en ... -2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0 …
Matched Description: … the patient's immune system and so the risk of organ rejection. ... Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of ... It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory …
Matched Products: … PROGRAF 5 MG/ML KONSANTRE IV INFUZYON ICIN SOLUSYON ICEREN AMPUL, 10 ADET …

Phentermine

Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows this agent to...
Approved
Illicit
Matched Description: … ] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers. ... Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity ... This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine …
Matched Salts cas: … 1197-21-3 …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Benzphetamine

A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)
Approved
Illicit
Matched Description: … It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sertindole

Sertindole, a neuroleptic, is one of the newer antipsychotic medications available. Serdolect is developed by the Danish pharmaceutical company H. Lundbeck. It is a phenylindole derivative used in the treatment of schizophrenia. It was first marketed in 1996 in several European countries before being withdrawn two years later because of...
Approved
Investigational
Withdrawn
Matched Description: … It is a phenylindole derivative used in the treatment of schizophrenia. ... Sertindole, a neuroleptic, is one of the newer antipsychotic medications available. ... first marketed in 1996 in several European countries before being withdrawn two years later because of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Pizotifen

Pizotifen belongs to the class of antamines and is related to cyproheptadine. It is a potent serotonin and tryptamine antagonist that has been used for migraine prevention for many years. It exhibits weak anticholinergic, antihistamine, and antikinin actions in addition to sedative and appetite-stimulating properties . Some patients receiving pizotifen...
Approved
Matched Description: … of its antimigraine action [A32538]. ... Pizotifen belongs to the class of antamines and is related to [cyproheptadine]. ... Sandomigran is available in a number of countries but is not approved by the FDA nor EMA. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Levomenol

Bisabolol, or more formally α-(−)-bisabolol or also known as levomenol, (-)-alpha-Bisabolol is found in fats and oils. (-)-alpha-Bisabolol is isolated from essential oil of Matricaria chamomilla (German chamomile) (-)-alpha-Bisabolol belongs to the family of Sesquiterpenes. These are terpenes with three consecutive isoprene units.
Approved
Experimental
Matched Iupac: … (2S)-6-methyl-2-[(1S)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol …
Matched Description: … alpha-Bisabolol belongs to the family of Sesquiterpenes. ... . (-)-alpha-Bisabolol is isolated from essential oil of Matricaria chamomilla (German chamomile) (-)- …

Mephenesin

Mephenesin is a synthetic cresol glyceryl ether which produces transient muscle relaxation and paralysis via central nervous system depression . It first entered use in the 1950s.
Approved

Bioallethrin

Bioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an approximate ratio of 1:1, where both isomers are active ingredients. A mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin. A mixture containing only S-forms...
Approved
Experimental
Matched Iupac: … 2-methyl-4-oxo-3-(prop-2-en-1-yl)cyclopent-2-en-1-yl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane …
Matched Description: … Bioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an ... A mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin ... approximate ratio of 1:1, where both isomers are active ingredients. …

Moxidectin

Moxidectin is a potent, broad-spectrum endectocide (antiparasitic that is active against endo- and ecto-parasites) with activity against nematodes, insects, and acari. It was first used in cattle followed by an approved use in general animals. It is a semi-synthetic methoxine derivative of nemadectin which is a 16-member pentacyclic lactone of...
Approved
Investigational
Vet approved
Matched Iupac: … (1'R,2R,4E,4'S,5S,6S,8'R,10'E,13'R,14'E,16'E,20'R,21'R,24'S)-21',24'-dihydroxy-4-(methoxyimino)-5,11' ... ,13',22'-tetramethyl-6-(4-methylpent-2-en-2-yl)-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1^ ... {4,8}.0^{20,24}]pentacosane]-10',14',16',22'-tetraen-2'-one …
Matched Description: … It is a semi-synthetic methoxine derivative of nemadectin which is a 16-member pentacyclic lactone of ... Moxidectin differs by the absence of a disaccharide moiety on carbon 13, a substituted olefinic side …

Zilucoplan

Zilucoplan is a 15 amino-acid, synthetic macrocyclic peptide. It is a complement inhibitor that works to prevent the activation of C5, which is a complement protein involved in the innate immune system to initiate inflammatory responses. On October 17, 2023, zilucoplan gained its first FDA approval for the treatment of...
Approved
Matched Description: … It is a complement inhibitor that works to prevent the activation of C5, which is a complement protein ... [A261841] On October 17, 2023, zilucoplan gained its first FDA approval for the treatment of generalized …

Olopatadine

Olopatadine is a selective histamine H1 antagonist and mast cell stabilizer that works by attenuating inflammatory and allergic reactions. It is a structural analog of doxepin, which has a minimal anti-allergic activity. Olopatadine works by blocking the effects of histamine, which is a primary inflammatory mediator that causes inflammatory and...
Approved
Matched Description: … An ophthalmic solution of olopatadine was approved by the FDA and European Union for the treatment of ... It is a structural analog of [doxepin], which has a minimal anti-allergic activity. ... [L6790] Olopatadine works by blocking the effects of histamine, which is a primary inflammatory mediator …

Aluminum chloride

Aluminum chloride is a chemical compound with the chemical formula AlCl3. When contaminated with iron chloride, it often displays a yellow color compared to the white pure compound. It is used in various chemical applications as a Lewis base, with anhydrous aluminium trichloride being the most commonly used Lewis acid....
Approved
Investigational
Matched Description: … In antiperspirant products, FDA approves the use of aluminum chloride as an active ingredient up to 15% …
Matched Products: … Gingi Aid 10% …

Durvalumab

Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote normal immune responses that attack tumour...
Approved
Investigational
Matched Description: … [L12621] In September 2018, durvalumab was approved by the EMA for the treatment of adult patients with ... use in combination with [etoposide] and either [carboplatin] or [cisplatin] as first-line treatment of ... locally advanced, unresectable non-small cell lung cancer (NSCLC), only if PD-L1 is expressed in ≥ 1% of …
Matched Products: … IMFINZI 500 MG/10 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET …

Adalimumab

Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor.[A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. This drug is frequently known as Humira. It is produced...
Approved
Experimental
Matched Description: … Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid ... [L49101] A biosimilar marketed as Hyrimoz, a high-concentration formulation of adalimumab, is also available …

Tiaprofenic acid

Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain. It belongs to the arylpropionic acid (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Approved
Matched Description: … Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly ... It belongs to the _arylpropionic acid_ (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs …

Mexiletine

Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties.
Approved
Investigational

Ipecac

Ipecac is obtained from the plant Cephaelis ipecacuanha and contains a number of emetic alkaloids including emetine and cephaeline. Ipecac was approved by Health Canada as an OTC but all those products are now discontinued. The FDA does not have currently any approved product containing ipecac, however, ipecac as an...
Approved
Withdrawn
Matched Description: … Ipecac is obtained from the plant _Cephaelis ipecacuanha_ and contains a number of emetic alkaloids including ... containing ipecac, however, ipecac as an ingredient is accepted to be sold over the counter in packages of …

Thyrotropin alfa

Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of...
Approved
Vet approved
Matched Description: … The alpha subunit of thyrotropin alfa, which is the effector region responsible for the stimulation of ... of 92 amino acid residues containing two N-linked glycosylation sites and a beta subunit of 112 residues ... The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating …

Cresol

Cresol is a hydroxytoluene that can be extracted naturally from coal tar or made synthetically. Pure cresol is a mixture of ortho-, meta-, and para- isomers. Cresols are precursors or synthetic intermediates to various other compounds and materials, including plastics, pesticides, pharmaceuticals, disinfectants, and dyes. Ingestion of cresol induces toxicity...
Approved
Matched Description: … Ingestion of cresol induces toxicity in humans and can lead to burning of the mouth and throat, abdominal ... Pure cresol is a mixture of ortho-, meta-, and para- isomers. …
Displaying drugs 401 - 425 of 9223 in total