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Displaying drugs 451 - 475 of 15574 in total
Valoctocogene roxaparvovec is an adeno-associated virus serotype 5 (AAV5) based gene therapy vector that expresses the B-domain deleted SQ form of human coagulation factor VIII (hFVIII-SQ). The expression of hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein and increase the levels of active...
Approved
Investigational
Matched Description: … It is not approved for use in the United States. ... to produce factor VIII protein and increase the levels of active factor VIII in blood. ... [L43282,A252807] Valoctocogene roxaparvovec was approved by EMA in September 2022 and is indicated for
Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis in February, 2017.
Approved
Investigational
Matched Iupac: … (2R)-2-amino-3-{[(2S)-2-{[(1R)-1-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido ... carbamoylbutyl]carbamoyl}ethyl]carbamoyl}butyl]carbamoyl}butyl]carbamoyl}butyl]carbamoyl}ethyl]carbamoyl}-2- …
Matched Description: … Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing ... HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis in February, 2017. ... Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism ( …
Matched Products: … PARSABIV SOLUTION FOR INJECTION 10 mg/2 mL ... PARSABİV 10 MG/2 ML I.V. ENJEKSİYONLUK ÇÖZELTİ, 1 ADET ... PARSABİV 10 MG/2 ML I.V. ENJEKSİYONLUK ÇÖZELTİ, 6 ADET …
Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity.
Approved
Withdrawn
Matched Iupac: … 5-(4-methylbenzoyl)-3-nitrobenzene-1,2-diol …
Matched Description: … It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. ... Tolcapone is associated with a risk of hepatotoxicity. ... It is a yellow, odorless, non-hygroscopic, crystalline compound. …
Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss. Chemically, it consists of 2 heavy...
Approved
Matched Description: … fracture receiving adjuvant aromatase inhibitor therapy for breast cancer in September 2011 and in men ... with osteoporosis at high risk for fracture in September 2012. ... [A263071] Chemically, it consists of 2 heavy and 2 light chains, with each light chain consisting of …
Matched Categories: … Drugs for Treatment of Bone Diseases …
Matched Products: … XGEVA 120mg Solution for Injection ... XGEVA Solution for Injection 120 mg/vial ... Prolia Solution for Injection 60mg Pre-filled Syringe …
Piperaquine is an antimalarial agent first synthesized in the 1960's and used throughout China . Its use declined in the 1980's as piperaquine resistant strains of Plasmodium falciparum appeared and artemisinin derivatives became available. It has come back into use in combination with the artemisinin derivative DB11638 as part of...
Approved
Experimental
Investigational
Matched Iupac: … 7-chloro-4-(4-{3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl}piperazin-1-yl)quinoline …
Matched Description: … Eurartesim was first authorized for market by the European Medicines Agency in October 2011. ... Piperaquine is an antimalarial agent first synthesized in the 1960's and used throughout China [A31550 ... Its use declined in the 1980's as piperaquine resistant strains of *Plasmodium falciparum* appeared and …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Sodium zirconium cyclosilicate is approved as the trade product Lokelma developed by AstraZeneca - an insoluble, non-absorbed sodium zirconium silicate, formulated as a powder for oral suspension that acts as a highly selective potassium removing agent. It is administered orally and is odorless, tasteless, and stable at room temperature. Approval...
Approved
Investigational
Matched Description: … powder for oral suspension that acts as a highly selective potassium removing agent. ... in the blood was 2.2 hours, with 92% of patients achieving normal potassium levels within 48 hours following ... [L2933] The treatment effect was maintained for up to 12 months.[L2933] …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …
Matched Products: … LOKELMA POWDER FOR ORAL SUSPENSION 5G ... LOKELMA POWDER FOR ORAL SUSPENSION 10G ... Lokelma 5g Powder for Oral Suspension …
Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms. Alprazolam's adverse...
Approved
Illicit
Investigational
Matched Synonyms: … 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine …
Matched Iupac: … 12-chloro-3-methyl-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene …
Matched Description: … Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders. ... [L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose ... [A18125] Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Products: … Alprazolam C-IV ... XANAX XR EXTENDED-RELEASE TABLET 3 mg ... ALPRAZOLAM RETARD 2 MG (TRICALMA RETARD 2 MG) …
Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. It was discovered by scientists at Medica Pharmaceutical Company in Finland. It is used in the UK as a treatment for migraine under the name of Clotam. In the US, it presents a Status class I by the...
Approved
Investigational
Matched Iupac: … 2-[(3-chloro-2-methylphenyl)amino]benzoic acid …
Matched Description: … Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory ... It is used in the UK as a treatment for migraine under the name of Clotam. ... [L1292] In the US, it presents a Status class I by the FDA. …
Matched Categories: … Non COX-2 selective NSAIDS …
Matched Products: … TOLFEDINE 4% W/V SOLUTION FOR INJECTION FOR DOGS AND CATS ... Tolfine Solution for Injection 4.0% W/V …
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like morphine and oxycodone. Fentanyl's high potency has also...
Approved
Illicit
Investigational
Vet approved
Matched Synonyms: … N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide …
Matched Iupac: … N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide …
Matched Description: … [A179542] In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose ... Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia ... Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. …
Matched Products: … DUROGESIC SMAT 12 A 2.1MG ... DUROGESIC SMAT 25 A 4.2MG ... DUROGESIC SMAT 50 A 8.4MG …
Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. Ixabepilone is...
Approved
Investigational
Matched Iupac: … (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4- ... yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione …
Matched Description: … It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally ... Ixabepilone is a semisynthetic analogue of epothilone B. ... Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Products: … IXEMPRA FOR INJECTION 15 MG ... IXEMPRA (FOR INJECTION 15 MG) ... IXEMPRA FOR INJECTION 45 MG …
Lutropin alfa is a recombinant human luteinizing hormone produced in yeast with 2 subunits, alpha = 92 residues, beta = 121 residues. It is a heterodimeric glycoprotein made up of monomeric units. Lutropin alfa was the first and only recombinant human form of luteinizing hormone (LH) developed for use in...
Approved
Matched Description: … Lutropin alfa is a recombinant human luteinizing hormone produced in yeast with 2 subunits, alpha = 92 ... Lutropin alfa was the first and only recombinant human form of luteinizing hormone (LH) developed for ... It is a heterodimeric glycoprotein made up of monomeric units. …
Matched Mixtures name: … PERGOVERIS 150 IU/75 IU ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ VE ÇÖZÜCÜ, 3 ADET ... Pergoveris 150IU/75IU powder and solvent for solution for injection ... Pergoveris Powder and Solvent for Solution for Injection 150iu/75iu …
Matched Products: … LUVERIS FOR INJECTION 75 iu/vial (Revised formula) …
Approved
Experimental
Matched Synonyms: … Diglycidyl bisphenol A ether …
Matched Name: … Bisphenol A diglycidyl ether …
Matched Iupac: … 2-{[4-(2-{4-[(oxiran-2-yl)methoxy]phenyl}propan-2-yl)phenoxy]methyl}oxirane …
Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation Factor VIII and it has the capacity to bind simultaneously to activated Factor IX and Factor X. The ability of Emicizumab to bind to all these three different factors allows it to overcome immunogenicity and unstable...
Approved
Investigational
Matched Description: … Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation ... The ability of Emicizumab to bind to all these three different factors allows it to overcome immunogenicity …
Matched Products: … HEMLIBRA 30MG/ML SOLUTION FOR INJECTION ... HEMLIBRA 150MG/ML SOLUTION FOR INJECTION ... HEMLIBRA SOLUTION FOR INJECTION 30MG/ML …
Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not...
Approved
Investigational
Matched Iupac: … -3-(naphthalen-2-yl)propanamido]propanamido]-3-(pyridin-3-yl)propanamido]-3-hydroxypropanamido]-3-(4- ... -2-yl]-2-[(2R)-5-(carbamoylamino)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2R)-3-(4-chlorophenyl)-2-[(2R)-2-acetamido ... (2S)-N-[(2S)-5-carbamimidamido-1-[(2S)-2-{[(1R)-1-carbamoylethyl]carbamoyl}pyrrolidin-1-yl]-1-oxopentan …
Matched Description: … Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). ... undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not ready for
Matched Products: … CETROTIDE 3 MG. ... CETROTIDE 3 MG ENJEKSİYON İÇİN LİYOFİLİZE TOZ İÇEREN FLAKON, 1 ADET ... Cetrotide 0.25 mg powder and solvent for solution for injection …
Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906.[A229008,A228593,A229108] Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues.[A229008,A228593] In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent...
Approved
Vet approved
Matched Description: … Vincent du Vigneaud; he was later recognized with a Nobel prize for his work. ... [A229013] Oxytocin also serves a role in metabolic homeostasis and cardiovascular regulation. ... [A229008,A228593] In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named …
Matched Products: … Oxytocin-Richter solution for injection 10 I.U / 1 ml ... ENJEKSİYONLUK ÇÖZELTİ, 3 ADET ... ENJEKSİYONLUK ÇÖZELTİ İÇEREN AMPUL, 3 ADET …
Cashew allergenic extract is used in allergenic testing.
Approved
Matched Description: … Cashew allergenic extract is used in allergenic testing. …
Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the dopamine receptor (mainly D2), particularly within...
Approved
Matched Synonyms: … 1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine …
Matched Description: … for the treatment of intractable hiccups as it is a potent antiemetic. ... [A180616] While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain ... or histaminergic receptors, resulting in a higher incidence of side effects such as sedation, weight …
Matched Products: … MYUNG IN HALOPERIDOL TABLET 1.5 mg ... MYUNG IN HALOPERIDOL INJECTION 5 mg/ml ... Haldol Decanoat 150 mg/3 ml Injektionslösung …
Iodine is commonly used as an antiseptic for minor cuts and abrasions, preventing infections that may result from contaminated wounds. Additionally, iodine has been studied in the treatment of fibrocystic disease and breast cancer.[A3413,A192153,A192156,A192159]
Approved
Investigational
Matched Description: … Iodine is commonly used as an antiseptic for minor cuts and abrasions, preventing infections that may ... Additionally, iodine has been studied in the treatment of fibrocystic disease and breast cancer. …
Matched Mixtures name: … Ni-C-E-LE Plus ... FLAVETTES DAILY PLUS TABLET F/C ... For-2
Matched Products: … XENETIX 350-50ML SOLN FOR INTRAVASCULAR INJ ... XENETIX 350-100ML SOLN FOR INTRAVASCULAR INJ ... XENETIX 300-50ML SOLN FOR INTRAVASCULAR, INTRAUTERINE AND INTRA-ARTICULAR INJ …
Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges , eyes , and inner ear . Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone...
Approved
Matched Iupac: … (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-{[(2-methyl-5,6-dioxo-1,2,5,6 ... -tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic …
Matched Description: … , its relatively safe adverse effect profile, and its long half-life which allows for the convenience ... Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. ... [A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the …
Matched Mixtures name: … CEF-3 INJECTION IM (1G) ... CEF-3 INJECTION IM (1G) ... CEF-3 INJECTION IM (250MG) …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … CEF-3 FOR IV INJECTION 500 mg/5 ml ... CEFTRIAXONA 1000 MG POLVO ESTERIL PARA RECONSTITUIR A SOLUCION INYECTABLE. ... CEFIN FOR INJECTION 2 g/vial …
Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta. Endogenously produced HCG interacts with the LHCG receptor of the ovary and promotes the maintenance of the corpus luteum during the beginning of pregnancy. This allows the corpus luteum to continuously secrete the hormone progesterone during the first...
Approved
Vet approved
Matched Description: … luteum to continuously secrete the hormone progesterone during the first trimester, which is required for ... As a drug product, chorionic gonadotropin is a highly purified pyrogen-free preparation obtained from ... In males, HCG also stimulates the production of gonadal steroid hormones by stimulating the interstitial …
Matched Products: … E. - Pulver und Lösungsmittel zur Herstellung einer Injektionslösung ... CHORAGON 5000 IU IM ENJEKSIYONLUK ÇÖZELTI IÇIN TOZ VE ÇÖZÜCÜ AMPUL, 3 ADET ... PREGNYL 1500 IU IM/SC ENJEKSİYON İÇİN LİYOFİLİZE TOZ İÇEREN FLAKON, 3 ADET …
Approved
Experimental
Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.
Approved
Matched Synonyms: … 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenz[b,f]azepine ... 10,11-dihydro-N,N,β-trimethyl-5H-dibenz[b,f]azepine-5-propanamine ... 5-(γ-dimethylamino-β-methylpropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine …
Matched Iupac: … (3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}-2-methylpropyl)dimethylamine …
Matched Salts cas: … 25332-13-2
Matched Categories: … Heterocyclic Compounds, 3-Ring ... Antidepressive Agents Indicated for Depression ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index …
Medroxyprogesterone acetate (MPA) is a progesterone derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prevent pregnancy, manage pain in endometriosis, prevent pregnancy, and is also...
Approved
Investigational
Matched Iupac: … )-1-acetyl-5,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … , and is also used in palliative care for endometrial and renal carcinoma. ... for improved pharmacokinetic properties. ... Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism …
Matched Mixtures name: … DIVINA 2 MG + 2 MG /10 MG TABLET, 21 ADET …
Matched Categories: … Hormonal Contraceptives for Systemic Use …
Matched Products: … DEPONEO 3
Agalsidase alfa is a recombinant human α-galactosidase A similar to agalsidase beta. While patients generally do not experience a clinically significant difference in outcomes between the two drugs, some patients may experience greater benefit with agalsidase beta.[A220228,A220233] Use of agalsidase beta has decreased in Europe, in favor of agalsidase alfa,...
Approved
Matched Synonyms: … alpha-galactosidase A ... Recombinant alpha-galactosidase A
Matched Description: … a contamination event in 2009. ... [A220343] Agalsidase alfa was granted EMA approval on 3 August 2001.[L16413] ... While patients generally do not experience a clinically significant difference in outcomes between the …
Matched Products: … REPLAGAL CONCENTRATE FOR SOLUTION FOR INFUSION 1 MG/ML …
Synthetic guanethidine derivative that locates phaeochromocytomas and neuroblastomas. The radioisotope used can either be iodine-123 for imaging or iodine-131 for destruction of tissues that metabolize noradrenaline. Iodine 123 is a cyclotron-produced radionuclide that decays to Te 123 by electron capture. Images are produced by a I123 MIBG scintigraphy. FDA approved...
Approved
Investigational
Matched Synonyms: … 3-iodobenzylguanidine ... ((3-iodophenyl)methyl)guanidine …
Matched Iupac: … N''-[(3-iodophenyl)methyl]guanidine …
Matched Description: … The radioisotope used can either be iodine-123 for imaging or iodine-131 for destruction of tissues that ... Images are produced by a I123 MIBG scintigraphy. FDA approved on September 19, 2008. ... Iodine 123 is a cyclotron-produced radionuclide that decays to Te 123 by electron capture. …
Matched Salts cas: … 149210-33-3
Matched Categories: … Compounds used in a research, industrial, or household setting …
Displaying drugs 451 - 475 of 15574 in total