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Displaying drugs 451 - 475 of 14740 in total

Canis lupus familiaris dander

Canis lupus familiaris dander is the dander of Canis lupus familiaris. Canis lupus familiaris dander is used in allergenic testing.
Approved
Matched Mixtures name: … Animal Allergens, AP Dog Hair and Dander Canis spp ... Animal Allergens, Dog Hair and Dander Canis spp. ... Animal Allergens, Dog Hair and Dander Canis spp. …

Tezacaftor

Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator class. It was developed by Vertex Pharmaceuticals and FDA approved in combination with ivacaftor to manage cystic fibrosis. This drug was approved by the FDA on February 12, 2018. Cystic Fibrosis is an autosomal recessive disorder caused...
Approved
Investigational
Matched Description: … [L1595] It was developed by Vertex Pharmaceuticals and FDA approved in combination with [ivacaftor] to ... [L6814] This drug was approved by the FDA on February 12, 2018. ... consequently abnormal fluid and ion transport across cell membranes. …
Matched Categories: … ivacaftor and tezacaftor ... ivacaftor, tezacaftor and elexacaftor …

Ivosidenib

Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivosidenib was granted accelerated approval by the FDA...
Approved
Investigational
Matched Description: … [L46287] It was fully approved by the EMA in May 2023.[L46596] ... [A248745] It is currently approved to also treat newly diagnosed acute myeloid leukemia in older adults ... and proliferation. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Azelastine

Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic conjunctivitis.[L8240,L8270] It is a racemic mixture, though there is no noted difference in pharmacologic activity between enantiomers, and was first...
Approved
Matched Description: … vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic conjunctivitis. ... phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and ... racemic mixture, though there is no noted difference in pharmacologic activity between enantiomers, and …
Matched Mixtures name: … Azelastine hydrochloride and Fluticasone propionate ... Azelastine Hydrochloride and Fluticasone Propionate ... Azelastine Hydrochloride and Fluticasone Propionate …
Matched Categories: … Decongestants and Antiallergics …

Articaine

Articaine is a dental local anesthetic. Articaine is widely used around the world and is the most popular local anesthetic in many European countries.
Approved
Matched Description: … Articaine is widely used around the world and is the most popular local anesthetic in many European countries …
Matched Mixtures name: … Septocaine and Epinephrine ... Septocaine and Epinephrine ... Articaine HCl and Epinephrine …

Larotrectinib

Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and...
Approved
Investigational
Matched Description: … It was notable for being the second tissue-agnostic chemotherapy ever approved by the FDA.[L4847] ... plays an important role in tumor cell growth and survival. ... receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Ansuvimab

Infection with pathogenic filoviruses, such as Zaire ebolavirus (Ebola virus, EBOV), can cause severe hemorrhagic fever in humans, resulting in frequent outbreaks with case fatality rates as high as 90%.[A225933, A225938] Virtually all steps of the EBOV lifecycle have been targeted for therapeutic development. However, to date, the most successful...
Approved
Investigational
Matched Description: … INMAZEB™ (REGN-EB3, a cocktail of [atoltivimab], [odesivimab], and [maftivimab]), the now approved ansuvimab ... Ansuvimab is just the second FDA-approved treatment for EVD.[L29560] ... , and ZMapp, which remains in clinical trials. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …

Iobenguane

Synthetic guanethidine derivative that locates phaeochromocytomas and neuroblastomas. The radioisotope used can either be iodine-123 for imaging or iodine-131 for destruction of tissues that metabolize noradrenaline. Iodine 123 is a cyclotron-produced radionuclide that decays to Te 123 by electron capture. Images are produced by a I123 MIBG scintigraphy. FDA approved...
Approved
Investigational
Matched Description: … FDA approved on September 19, 2008. ... Synthetic guanethidine derivative that locates phaeochromocytomas and neuroblastomas. …
Matched Categories: … Indicators and Reagents …

Isometheptene

Isometheptene is a sympathomimetic drug that causes vasoconstriction. It is used for treating migraines and tension headaches.
Approved
Matched Description: … It is used for treating migraines and tension headaches. …
Matched Mixtures name: … Isometheptene Mucate, Caffeine, and Acetaminophen ... Isometheptene Mucate, Caffeine, and Acetaminophen ... Isometheptene Mucate, Caffeine, and Acetaminophen …
Matched Categories: … Alimentary Tract and Metabolism …

Zinc gluconate

Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for...
Approved
Vet approved
Matched Description: … of common colds and with decreased symptom severity. ... It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration ... osmolarity oral rehydration solutions/salts (oral rehydration solution), may reduce both the duration and …
Matched Mixtures name: … Multivitamin and Mineral ... Zinc and Algin Tab Nu Life ... Cal-mag Vitamin C and Zinc Tab …
Matched Categories: … Alimentary Tract and Metabolism ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Susoctocog alfa

Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). AHA is a rare bleeding disorder that results in a prolonged clotting time as measured by the...
Approved
Investigational
Matched Description: … Susoctocog alfa was approved by the FDA in October 2014 and is marketed under the brand name Obizur for ... B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved ... It is the first recombinant porcine FVIII treatment approved for AHA that allows physicians to manage …
Matched Categories: … Blood and Blood Forming Organs …

Benzphetamine

A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)
Approved
Illicit
Matched Categories: … Antidepressive Agents …

Sertindole

Sertindole, a neuroleptic, is one of the newer antipsychotic medications available. Serdolect is developed by the Danish pharmaceutical company H. Lundbeck. It is a phenylindole derivative used in the treatment of schizophrenia. It was first marketed in 1996 in several European countries before being withdrawn two years later because of...
Approved
Investigational
Withdrawn
Matched Description: … It has once again been approved and should soon be available on the French and Australian market. …
Matched Categories: … Antidepressive Agents …

Cyproheptadine

Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.
Approved
Matched Description: … Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. ... treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation[L32519] and …
Matched Categories: … Antidepressive Agents …

Cyclobenzaprine

Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from Amitriptyline by only a single double bond.[A185039,A184982] Since its approval, it has...
Approved
Matched Description: … Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961[A185039] and has been …
Matched Categories: … Antidepressive Agents …

Pizotifen

Pizotifen belongs to the class of antamines and is related to cyproheptadine. It is a potent serotonin and tryptamine antagonist that has been used for migraine prevention for many years. It exhibits weak anticholinergic, antihistamine, and antikinin actions in addition to sedative and appetite-stimulating properties . Some patients receiving pizotifen...
Approved
Matched Description: … Sandomigran is available in a number of countries but is not approved by the FDA nor EMA. ... It exhibits weak anticholinergic, antihistamine, and antikinin actions in addition to sedative and appetite-stimulating ... Pizotifen belongs to the class of antamines and is related to [cyproheptadine]. …
Matched Categories: … Antidepressive Agents …

Dichlorobenzyl alcohol

Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections. Dichlorobenzyl alcohol is considered as an active ingredient found in several marketed OTC products by Health Canada which has categorized this agent as an anatomical therapeutic chemical. On the other...
Approved
Matched Description: … with mouth and throat infections. ... On the other hand, dichlorobenzyl alcohol is categorized by the FDA in the inactive ingredient for approved ... Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated …
Matched Mixtures name: … STREPSILS HONEY AND LEMON ... STREPSILS SORE THROAT AND BLOCKED NOSE LOZENGE ... Difflam plus ANAESTHETIC Sore Throat Lozenges (Sugar Free) Menthol and Eucalyptus Flavour …

Sotalol

Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening...
Approved
Matched Description: … [A178579] Sotalol was first approved as an oral tablet on 30 October 1992. ... injection indicated for life threatening ventricular arrhythmias and maintaining normal sinus rhythm ... [L6334] A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous …
Matched Categories: … sotalol and thiazides ... Beta Blocking Agents and Thiazides ... sotalol and acetylsalicylic acid ... Beta Blocking Agents, Non-Selective, and Thiazides …

Oxybuprocaine

Oxybuprocaine (also known as Benoxinate) is a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.
Approved
Investigational
Matched Description: … Oxybuprocaine (also known as Benoxinate) is a local anesthetic, which is used especially in ophthalmology and ... Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases …
Matched Mixtures name: … Fluorescein Sodium and Benoxinate Hydrochloride ... Fluorescein Sodium and Benoxinate Hydrochloride ... Fluorescein Sodium and Benoxinate Hydrochloride …

Droxidopa

Droxidopa is a precursor of noradrenaline that is used in the treatment of Parkinsonism. It is approved for use in Japan and is currently in trials in the U.S. The racaemic form (dl-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a...
Approved
Investigational
Matched Description: … It is approved for use in Japan and is currently in trials in the U.S. ... Provided L-DOPS successfully completes clinical trials, it could be approved for the treatment of neurogenic ... associated with Parkinson's disease , pure autonomic failure, and multiple system atrophy, and is the …
Matched Categories: … Epinephrine and similars ... Adrenergic and Dopaminergic Agents ... Amino Acids, Peptides, and Proteins …

Potassium chloride

A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of...
Approved
Withdrawn
Matched Description: … in fertilizers and explosives. ... that supply 100 mg or more of potassium per dosage unit, except for controlled-release dosage forms and ... crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and …
Matched Mixtures name: … Plasma-Lyte 148 and dextrose ... Ringers and Dextrose ... Ionosol and Dextrose …
Matched Categories: … Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …

Terconazole

Terconazole is an anti-fungal drug that is mainly used to treat vaginal yeast infections (or vaginal candidiasis). It is classified as a triazole ketal derivative. Terconazole was initially approved by the FDA in 1987.[FDA label] This drug is available in cream and suppository forms and both have demonstrated high levels...
Approved
Matched Description: … [A178096] Terconazole was initially approved by the FDA in 1987. ... [FDA label] This drug is available in cream and suppository forms and both have demonstrated high levels ... of safety, efficacy, and tolerability in clinical trials. …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Potassium citrate

Potassium citrate (also known as tripotassium citrate) is a potassium salt of citric acid. It is a white, hygroscopic crystalline powder. It is odorless with a saline taste. It contains 38.3% potassium by mass. In the monohydrate form it is highly hygroscopic and deliquescent. Potassium citrate is used to treat...
Approved
Investigational
Vet approved
Matched Description: … In the monohydrate form it is highly hygroscopic and deliquescent. …
Matched Mixtures name: … Calcium and Mag-potass and Zinc Cap ... Potassium Citrate and Citric Acid ... Children's Chewable Vit and Min Tab …
Matched Categories: … Alimentary Tract and Metabolism …

Lopinavir

Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with ritonavir - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to lopinavir's poor oral bioavailability...
Approved
Matched Description: … "boosts" lopinavir exposure and improves antiviral activity. ... Abbott under the brand name Kaletra in 2000, is necessary due to lopinavir's poor oral bioavailability and ... [L11163] Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination …
Matched Mixtures name: … Lopinavir and Ritonavir ... Lopinavir and ritonavir ... Lopinavir and ritonavir …
Matched Categories: … lopinavir and ritonavir ... Metabolic Side Effects of Drugs and Substances …

Glycerol phenylbutyrate

Glycerol phenylbutyrate is a nitrogen-binding agent. Chemically, it is a triglyceride in which three molecules of phenylbutyrate are linked to a glycerol backbone. FDA approved on February 1, 2013.
Approved
Matched Description: … FDA approved on February 1, 2013. …
Matched Categories: … Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …
Displaying drugs 451 - 475 of 14740 in total