Displaying drugs 476 - 500 of 8033 in total
Bethanechol
Bethanechol is a synthetic ester that was initially synthesized in 1935.[A232905,L32539] As a cholinergic agent, bethanechol is similar in structure and pharmacological function to acetylcholine and is used in specific cases when stimulation of the parasympathetic nervous system is necessary.[A232905,L32539] For example, bethanechol is readily used to treat postoperative or...
Approved
Matched Description: … structure and pharmacological function to acetylcholine and is used in specific cases when stimulation of ... An advantage of bethanechol is that in contrast to acetylcholine, bethanechol is not degraded by cholinesterase …
Tocofersolan
D-Alpha-tocopheryl polyethylene glycol 1000 succinate (Tocofersolan, Vedrop), has been developed in Europe as an orally bioavailable source of vitamin E in children suffering from cholestasis . Cholestasis is the reduction or stoppage of bile flow, either to impaired secretion by hepatocytes (liver cells) or obstruction , .
Tocofersolan is a...
Approved
Matched Description: … of [DB11251]. ... 1000 succinate (Tocofersolan, Vedrop), has been developed in Europe as an orally bioavailable source of ... Cholestasis is the reduction or stoppage of bile flow, either to impaired secretion by _hepatocytes_ …
Encorafenib
Encorafenib, also known as BRAFTOVI, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and secretion. Mutations in this gene,...
Approved
Investigational
Matched Description: … colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of …
Metformin
Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173]
Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "insulin sensitizer", leading to a decrease in insulin...
Approved
Matched Description: … Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of ... [A176173] Another well-known benefit of this drug is modest weight loss, making it an effective choice ... insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of …
Podofilox
A lignan found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and...
Approved
Matched Description: … A lignan found in podophyllin resin from the roots of podophyllum plants. ... actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of …
Ceftolozane
Ceftolozane is a semi-synthetic broad-spectrum fifth generation cephalosporin. It was approved by the FDA in 2014 for use in combination with Tazobactam for the treatment of serious infections, such as intra-abdominal infections and complicated urinary tract infections. The manufacturer of this drug is Cubist Pharmaceuticals. Most recently, in June 2019,...
Approved
Investigational
Matched Description: … The manufacturer of this drug is Cubist Pharmaceuticals. ... L6685] It was approved by the FDA in 2014 for use in combination with [Tazobactam] for the treatment of ... and mortality in hospitalized patients and the use of ceftolozane-tazobactam offers effective activity …
Terazosin
Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertension[FDA Label] . Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate .
Approved
Matched Description: … Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle …
Tocilizumab
Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 January 2010 to treat a...
Approved
Matched Description: … autoimmune disorders, such as different types of arthritis and cytokine release syndrome. ... [A193281] Tocilizumab was granted FDA approval on 8 January 2010 to treat a number of inflammatory and ... [L12789] It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing …
Lanreotide
Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured by the company, Ipsen...
Approved
Matched Description: … This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. ... Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess …
Testosterone cypionate
Testosterone cypionate is a synthetic derivative of testosterone in the form of an oil-soluble 17 (beta)-cyclopentylpropionate ester. Its benefit compared to other testosterone derivatives is the slow rate of release after injection and longer half-life. It was developed by the company Pharmacia and Upjohn and FDA approved on July 25,...
Approved
Matched Description: … Testosterone cypionate is a synthetic derivative of testosterone in the form of an oil-soluble 17 (beta ... Its benefit compared to other testosterone derivatives is the slow rate of release after injection and …
Linaclotide
Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist.[A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C. It is also a homolog of a heat-stable enterotoxin derived from Escherichia coli, the first natural ligand...
Approved
Matched Description: … [A260286]
Linaclotide is used for the treatment of various types of constipation, including irritable ... Linaclotide works to improve the symptoms of constipation and gastrointestinal symptoms of conditions ... related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of …
Estradiol
Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches, sprays, gels, and creams.[L11485,L11488,L11491,...
Approved
Investigational
Vet approved
Matched Description: … [DB00977] (EE) is a synthetic form of estradiol commonly used as the estrogenic component of most combination ... Some available forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches …
Matched Categories: … Sex Hormones and Modulators of the Genital System …
Matched Categories: … Sex Hormones and Modulators of the Genital System …
Alclometasone
Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
Approved
Aminoglutethimide
An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale,...
Approved
Investigational
Matched Description: … An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of ... It also blocks the conversion of androgens to estrogens. ... Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. …
Ustekinumab
Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic disease-modifying anti-rheumatic drug (bDMARDs) that...
Approved
Investigational
Matched Description: … [A187349] It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice ... various inflammatory conditions that involve the activation of IL-12 and IL-23 signalling pathways. ... a targeted biologic disease-modifying anti-rheumatic drug (bDMARDs) that is used in the management of …
Dipotassium phosphate
Dipotassium phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive as a source of phosphorus and potassium as well as a buffering agent.
Approved
Matched Description: … phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive as a source of …
Isosorbide mononitrate
Isosorbide mononitrate is an organic nitrate with vasodilating properties. It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload.[L11698, L11743] Isosorbide mononitrate is an active metabolite of isosorbide dinitrate. Like other organic nitrates, isosorbide mononitrate...
Approved
Matched Description: … onset of absorption and metabolism. ... angina pectoris caused by coronary artery disease; however, the onset of action of orally-administered ... [L11698, L11743] Isosorbide mononitrate is an active metabolite of [isosorbide dinitrate]. …
Fosamprenavir
Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.
Approved
Matched Description: … Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease …
Testosterone propionate
Testosterone propionate is a slower-releasing anabolic steroid with a short half-life. It is a synthetic androstane steroid derivative of testosterone in the form of 17β propionate ester of testosterone. Testosterone propionate was developed initially by Watson labs, and FDA approved on February 5, 1974. Currently, this drug has been discontinued...
Approved
Investigational
Vet approved
Withdrawn
Matched Description: … It is a synthetic androstane steroid derivative of testosterone in the form of 17β propionate ester of …
Selenium
Selenium is a trace metal in the human body particularly important as a component of glutathione peroxidase, an important enzyme in the prevention of cellular damage by free radicals and reactive oxygen species [FDA Label]
Approved
Investigational
Vet approved
Matched Description: … Selenium is a trace metal in the human body particularly important as a component of glutathione peroxidase ... , an important enzyme in the prevention of cellular damage by free radicals and reactive oxygen species …
Pimecrolimus
Pimecrolimus is an immunomodulating agent that was first marketed by Novartis under the trade name Elidel. It is now promoted in Canada by Galderma since early 2007. It is currently available as a topic cream used in the treatment of atopic dermatitis (eczema).
Approved
Investigational
Matched Description: … It is currently available as a topic cream used in the treatment of atopic dermatitis (eczema). …
Ferrous succinate
Approved
Iron
A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron...
Approved
Matched Description: … It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme ... Depletion of iron stores may result in iron-deficiency anemia. ... Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms …
Pramlintide
Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes.
Approved
Investigational
Selinexor
Selinexor is a first-in-class selective inhibitor of nuclear transport (SINE) compound. Selinexor, in combination with bortezomib and dexamethasone, is currently approved for the treatment of multiple myeloma, a type of cancer formed from antibody-producing plasma cells.[L7117,L7120,L10145] This condition is typically treated with high dose bortezomib and dexamethasone chemotherapy followed by...
Approved
Investigational
Matched Description: … Selinexor is a first-in-class selective inhibitor of nuclear transport (SINE) compound. ... multiple myeloma, a type of cancer formed from antibody-producing plasma cells. ... Selinexor, in combination with [bortezomib] and [dexamethasone], is currently approved for the treatment of …
Displaying drugs 476 - 500 of 8033 in total