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Displaying drugs 476 - 500 of 11997 in total

Apalutamide

Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resistant Prostate Cancer, and Prostatic...
Approved
Investigational
Matched Description: … In mice bearing human CRPC xenograft models, apalutamide treatment produced tumor regressions in a dose-dependent ... Apalutamide displayed good tolerability and safety profile in clinical studies. ... It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms …

Denosumab

Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss. Chemically, it consists of 2 heavy...
Approved
Matched Description: … September 2011 and in men with osteoporosis at high risk for fracture in September 2012. ... and women at high risk for fracture receiving adjuvant aromatase inhibitor therapy for breast cancer in ... It further received additional indication approval to increase bone mass in men at high risk for fracture …

Phosphoric acid

Phosphoric Acid is a colorless, odorless phosphorus-containing inorganic acid. Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++, and Mg++.
Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …

Xanthan gum

Xanthan gum is a polysaccharide gum derived from* Xanthomonas campestris* by a pure-culture fermentation process and purified by recovery with isopropyl alcohol. The major constituents include D-glucose, D-mannose, and D-glucuronic acid. Xanthan gum is a direct food additive permitted for direct addition to food for human consumption by the FDA....
Approved
Matched Description: … It is used as a thickening agent and stabilizer in emulsions. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Dimercaptosuccinic acid

Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Niclosamide

Niclosamide is an antihelminthic used for the treatment of tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms....
Approved
Investigational
Vet approved
Matched Description: … by Bayer in 1996. ... They are an even greater problem in domestic animals. ... Niclosamide, once marketed in the US under the brand name Niclocide, was voluntarily withdrawn from market …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Manidipine

Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.
Approved
Investigational

Ansuvimab

Infection with pathogenic filoviruses, such as Zaire ebolavirus (Ebola virus, EBOV), can cause severe hemorrhagic fever in humans, resulting in frequent outbreaks with case fatality rates as high as 90%.[A225933, A225938] Virtually all steps of the EBOV lifecycle have been targeted for therapeutic development. However, to date, the most successful...
Approved
Investigational
Matched Description: … humans, resulting in frequent outbreaks with case fatality rates as high as 90%. ... pathogenic filoviruses, such as _Zaire ebolavirus_ (Ebola virus, EBOV), can cause severe hemorrhagic fever in ... atoltivimab], [odesivimab], and [maftivimab]), the now approved ansuvimab, and ZMapp, which remains in …

Yttrium Y-90

Yttrium 90 has been investigated for the treatment of Colon Cancer and Colorectal Cancer.
Approved
Investigational

Cumin

Cumin allergenic extract is used in allergenic testing.
Approved
Matched Description: … Cumin allergenic extract is used in allergenic testing. …

Doxorubicin

Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed...
Approved
Investigational
Matched Description: … cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in ... [A257614] Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat …

Azithromycin

Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration . It was initially approved by the FDA in 1991 . It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for...
Approved
Matched Description: … It was initially approved by the FDA in 1991 [A174175]. ... In March 2020, a small study was funded by the French government to investigate the treatment of COVID …
Matched Products: … GLED' C ZIT …

Levetiracetam

Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918]...
Approved
Matched Description: … It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated ... of drugs notorious for having generally narrow therapeutic indexes and a propensity for involvement in …
Matched Products: … Levetiracetam in Sodium Chloride …

Hydrocortisone acetate

Approved
Vet approved
Matched Mixtures name: … ZISUAL-C ... HYDRODERM-C CREAM 1% …

Gliquidone

Gliquidone is a sulfonylurea drug used to treat diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release.
Approved
Investigational
Matched Categories: … Drugs Used in Diabetes …

Chlorobutanol

Chlorobutanol, or chlorbutol, is an alcohol-based preservative with no surfactant activity . It also elicits sedative-hypnotic and weak local anesthetic actions in addition to antibacterial and antifungal properties. Similar in nature to chloral hydrate, it is formed by the simple nucleophilic addition of chloroform and acetone. As a long-term stabilizer...
Approved
Investigational
Vet approved
Matched Description: … It also elicits sedative-hypnotic and weak local anesthetic actions in addition to antibacterial and ... Similar in nature to chloral hydrate, it is formed by the simple nucleophilic addition of chloroform ... Chlorobutanol is a common detergent preservative in eye drops and other ophthalmic therapeutic formulations …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Padimate O

Padimate O is an active sunscreen agent in cosmetics and over-the-counter sunscreen drug products in concentrations up to 8%, as regulated by the FDA . It is a structurally-related compound to DB02362 that absorbs UV-B rays to prevent photodamage. It penetrates human skin, and is shown to induce non-ligatable strand...
Approved
Matched Description: … Padimate O is an active sunscreen agent in cosmetics and over-the-counter sunscreen drug products in …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Cyanocobalamin Co-60

Cyanocobalamin Co-60 is an analog of Vitamin B12 labeled with Co60. Cyanocobalamin Co-60 was used for the diagnosis of pernicious anemia, but now it is withdrawn from the market in the US for unknown reasons.
Approved
Withdrawn
Matched Description: … Cyanocobalamin Co-60 was used for the diagnosis of pernicious anemia, but now it is withdrawn from the market in …

Tyloxapol

Tyloxapol is a non-ionic detergent often used as a surfactant.
Approved
Investigational
Matched Categories: … Compounds used in a research, industrial, or household setting …

Pentastarch

Pentastarch is an artificial colloid (hydroxyethyl starch derivative). Pentastarch is characterized by presenting five hydroxyethyl groups, which signifies an approximate 50% hydroxyethylation. It is sold under the name Pentaspan by Bristol-Myers Squibb and is used for fluid resuscitation. When administered, pentastarch remains mainly in the circulatory system and hence, it...
Approved
Investigational
Matched Description: … When administered, pentastarch remains mainly in the circulatory system and hence, it is considered a …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Boric acid

Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive in pharmaceutical products, cosmetics, lotions, soaps, mouthwash, toothpaste, astringents, and eyewashes . It...
Approved
Matched Description: … in pharmaceutical products, cosmetics, lotions, soaps, mouthwash, toothpaste, astringents, and eyewashes ... Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Deferoxamine

Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Approved
Investigational
Matched Description: … It forms iron complexes and is used as a chelating agent, particularly in the mesylate form. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Doripenem

Doripenem is a broad-spectrum, carbapenem antibiotic marketed under the brand name Doribax by Janssen. Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal infections. In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin), it was found that...
Approved
Investigational
Matched Description: … The FDA revised the doripenem label in 2014 to include a warning against use in ventilator-associated ... In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin ... Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal …

Amaranthus hybridus pollen

Amaranthus hybridus pollen allergenic extract is used in allergenic testing.
Approved
Matched Description: … Amaranthus hybridus pollen allergenic extract is used in allergenic testing. …

Potassium citrate

Potassium citrate (also known as tripotassium citrate) is a potassium salt of citric acid. It is a white, hygroscopic crystalline powder. It is odorless with a saline taste. It contains 38.3% potassium by mass. In the monohydrate form it is highly hygroscopic and deliquescent. Potassium citrate is used to treat...
Approved
Investigational
Vet approved
Matched Description: … In the monohydrate form it is highly hygroscopic and deliquescent. …
Matched Mixtures name: … C-1000 Plus Zinc & Potassium …
Displaying drugs 476 - 500 of 11997 in total