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Displaying drugs 526 - 550 of 14641 in total

Bictegravir

Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet.
Approved
Investigational
Matched Description: … recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and …
Matched Categories: … emtricitabine, tenofovir alafenamide and bictegravir …

Hexobendine

Hexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has been used widely in Austria and Germany .
Approved
Matched Description: … has not been approved in the United States or the United Kingdom, but has been used widely in Austria and …

Ritiometan

Ritiometan is a nasal spray which is marketed by the name Nécyrane in France. It is indicated for use in viral rhinitis/ the common cold.
Approved

Bismuth subgallate

Bismuth subgallate is a yellow colored substance that presents as an odorless powder that undergoes discoloration when exposed to sunlight. It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed. Possessing protective effects on the gastric mucosa, strong astringent effects, and not as yet...
Approved
Matched Description: … It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed. ... Possessing protective effects on the gastric mucosa, strong astringent effects, and not as yet elucidated ... antimicrobial and hemostatic actions, bismuth subgallate is most commonly available as an over-the-counter …
Matched Categories: … Antacids and Adsorbents …

p-Phenylenediamine

Approved
Experimental
Matched Categories: … Indicators and Reagents ... Amino Acids, Peptides, and Proteins …

Velaglucerase alfa

Velaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of Type 1 Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase. Additionally, Velaglucerase alfa has also been investigated for use in Type 3 Gaucher disease.
Approved
Investigational
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …

Oseltamivir

Oseltamivir (marketed as the product TamifluⓇ), is an antiviral neuraminidase inhibitor used for the treatment and prophylaxis of infection with influenza viruses A (including pandemic H1N1) and B. Oseltamivir exerts its antiviral activity by inhibiting the activity of the viral neuraminidase enzyme found on the surface of the virus, which...
Approved
Matched Description: … that early antiviral treatment can shorten the duration of fever and illness symptoms, and may reduce ... prophylaxis of infection with influenza viruses A (including pandemic H1N1) and B. ... the risk of some complications (including pneumonia and respiratory failure). …

Phentolamine

Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[A261781, A261786] It has several therapeutic uses, including...
Approved
Matched Description: … to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and ... [L48420, L48415, L48390] Phentolamine is administered intravenously, intramuscularly, submucosally, and ... norepinephrine-induced extravasation, diagnosis of pheochromocytoma, reversal of soft-tissue anesthesia, and …

Eflornithine

Eflornithine is an irreversible ornithine decarboxylase inhibitor originally developed as a treatment for human African trypanosomiasis. Further research has also implicated ornithine decarboxylase in other conditions like facial hirsutism and cancer, especially when ornithine decarboxylase is highly upregulated in tumor cells.[A4112, A262834] Additionally, ornithine decarboxylase is activated by c-myc or...
Approved
Withdrawn
Matched Description: … [A262839] In 1960 and 2000, the FDA approved eflornithine under the brand names ORNIDYL and VANIQUA ... Further research has also implicated ornithine decarboxylase in other conditions like facial hirsutism and ... under the brand name IWILFIN as an oral maintenance therapy to reduce the risk of relapse in adult and …
Matched Categories: … Skin and Mucous Membrane Agents ... Amino Acids, Peptides, and Proteins ... Agents Against Leishmaniasis and Trypanosomiasis ... Antineoplastic and Immunomodulating Agents ... Antiparasitic Products, Insecticides and Repellents …

Oxyquinoline

Oxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and pesticide properties. It is used as a stabilizer for hydrogen peroxide, where it is sometimes added in cosmetic products.
Approved
Vet approved
Matched Description: … Oxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and …
Matched Categories: … Alimentary Tract and Metabolism ... Antiseptics and Disinfectants ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Antiinfectives and Antiseptics for Local Oral Treatment …

Artesunate

Artesunate is indicated for the initial treatment of severe malaria. The World Health Organization recommends artesunate as first line treatment for severe malaria. Artesunate was developed out of a need for a more hydrophilic derivative of artemisinin. Artesunate was granted FDA approval on 26 May 2020.
Approved
Investigational
Matched Categories: … Artemisinin and derivatives ... artesunate and mefloquine ... artesunate and amodiaquine ... artesunate and pyronaridine ... artesunate, sulfalene and pyrimethamine …

Beremagene geperpavec

Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector therapy. Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of wounds associated with dystrophic epidermolysis bullosa (DEB). DEB is caused by mutations in the COL7A1 gene that...
Approved
Matched Categories: … Cellular and Gene Therapy ... Preparations for Treatment of Wounds and Ulcers …

Trypsin

Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of the amino acids lysine or arginine....
Approved
Vet approved
Matched Description: … Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals ... Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is ... nucleophilic attack is facilitated by the catalytic triad consisting of histidine-57, aspartate-102, and …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Preparations for Treatment of Wounds and Ulcers …

Nortriptyline

Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA). It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.
Approved
Matched Description: … and other conditions. ... [L11878] It is used in the treatment of major depression and is also used off-label for chronic pain …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …

Ethylhexyl methoxycrylene

Ethylhexyl methoxycrylene is a photostabilizer that preserves the effectiveness of UV filters by interacting with both the singlet and triplet states . It returns UV filters to their ground states without absorbing sunlight . It is used as a solvent for crystalline UV filters and is easily emulsified and suitable...
Approved
Experimental
Matched Description: … It is used as a solvent for crystalline UV filters and is easily emulsified and suitable for use in various ... lotions, creams, sprays, sticks, and gel formulations [F104]. ... It currently enjoys regional approvals in Canada, the EU, and the US [L2847]. …

Diroximel fumarate

Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting forms of MS...
Approved
Investigational
Matched Description: … in October 2019[L9626] and by the EMA in November 2021. ... Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and ... Relapsing-remitting forms of MS lead to neurological symptoms that resolve and recur periodically. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Sulfametopyrazine

Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.
Approved
Withdrawn
Matched Description: … Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria …
Matched Categories: … Sulfonamides and trimethoprim ... Genito Urinary System and Sex Hormones ... artesunate, sulfalene and pyrimethamine ... Gynecological Antiinfectives and Antiseptics ... Antiparasitic Products, Insecticides and Repellents …

Trichlormethiazide

A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)
Approved
Vet approved
Matched Categories: … trichlormethiazide and potassium ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... trichlormethiazide and potassium-sparing agents ... Low-Ceiling Diuretics and Potassium-Sparing Agents …

Methysergide

An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the...
Approved
Matched Description: … Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin ... It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has …
Matched Categories: … Ergot Alkaloids and Derivatives …

Dicoumarol

Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Approved
Matched Categories: … Blood and Blood Forming Organs …

Methylergometrine

A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)
Approved
Matched Categories: … Ergot Alkaloids and Derivatives ... methylergometrine and oxytocin ... Genito Urinary System and Sex Hormones …

Vinorelbine

Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction...
Approved
Investigational
Matched Description: … chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Quinine

An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in...
Approved
Matched Description: … It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis ... Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that ... , because of its direct effects on muscle membrane and sodium channels. …
Matched Categories: … Quinine and stereoisomer ... Antiparasitic Products, Insecticides and Repellents …

Oxytetracycline

A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions.
Approved
Investigational
Vet approved
Matched Description: … A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety …
Matched Categories: … Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Antiinfectives and Antiseptics for Local Oral Treatment …

Demeclocycline

A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Approved
Matched Description: … A tetracycline analog having a 7-chloro and a 6-methyl. …
Displaying drugs 526 - 550 of 14641 in total