Displaying drugs 651 - 675 of 11932 in total
Moroctocog alfa
Moroctocog alfa, also known as BDDrFVIII (B domain deleted recombinant factor VIII), is a recombinant DNA-based drug with functional characteristics comparable to those of endogenous coagulation Factor VIII, the essential human blood clotting protein that is impaired in Hemophilia A. Moroctocog alfa is identical in sequence to endogenously produced Factor...
Approved
Matched Description: … Moroctocog alfa, also known as BDDrFVIII (B domain deleted recombinant factor VIII), is a recombinant ... in the Factor VIII gene, leading to a functional deficiency or complete loss of protein. ... coagulation Factor VIII, the essential human blood clotting protein that is impaired in Hemophilia A. …
Budesonide
Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532]
Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product...
Approved
Matched Description: … Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions ... [L10598] It is also available in a combination product with [formoterol].[L10619] …
Vandetanib
Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types.
On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients.
Approved
Matched Description: … kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Lifitegrast
Lifitegrast is a FDA approved drug for the treatment of keratoconjunctivitis sicca (dry eye syndrome). It is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design process. The ophthalmic solution was approved in July, 2016 under the trade name Xiidra. It has...
Approved
Matched Description: … Lifitegrast is a FDA approved drug for the treatment of keratoconjunctivitis sicca (dry eye syndrome) ... It is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Factor XIII (human)
Factor XIII (human) is a heat-treated, lyophilized concentrate of coagulation factor XIII, an endogenous enzyme responsible for the crosslinking of fibrin and an essential component of the coagulation cascade [FDA Label]. For people with congenital deficiency or mutation of Factor XIII, a rare bleeding disorder, exogenous replacement of this key...
Approved
Investigational
Matched Description: … Within the body, FXIII circulates as a heterotetramer composed of 2 A-subunits and 2 B-subunits (A2B2 ... As a result, the active transglutaminase from subunit A cross-links fibrin and other proteins resulting ... recombinant form of the A subunit of human coagulation factor XIII. …
Penbutolol
Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high binding affinity to the...
Approved
Investigational
Matched Description: … Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric ... Penbutolol is a drug in the beta-blocker class used to treat hypertension. ... Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker …
Magaldrate
Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market.
Approved
Withdrawn
Ertugliflozin
Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018.
Approved
Investigational
Matched Description: … Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes …
Iodide I-123
Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect...
Approved
Matched Description: … Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for ... After incorporation, a gamma camera is used to detect the decay by electron capture to tellurium-123. ... half-life of approximately 13.13 h (hours) is ideal for the 24-h (hour) iodine uptake test and it has a …
Oxybuprocaine
Oxybuprocaine (also known as Benoxinate) is a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.
Approved
Investigational
Matched Description: … Oxybuprocaine (also known as Benoxinate) is a local anesthetic, which is used especially in ophthalmology …
Olanzapine
Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions. Olanzapine very closely resembles clozapine and only differs by...
Approved
Investigational
Matched Description: … Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent ... very closely resembles [clozapine] and only differs by two additional methyl groups and the absence of a …
Nitrofurantoin
Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections.[L6856,L6859,L6862] Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. This drug is more resistant to the development of bacterial resistance because it acts...
Approved
Vet approved
Matched Description: … Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections. ... [A179824] Nitrofurantoin is a second line treatment to [trimethoprim]/[sulfamethoxazole]. …
Meclofenamic acid
A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
Approved
Vet approved
Matched Description: … A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. …
Dichlorobenzyl alcohol
Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections. Dichlorobenzyl alcohol is considered as an active ingredient found in several marketed OTC products by Health Canada which has categorized this agent as an anatomical therapeutic chemical. On the other...
Approved
Matched Description: … Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated …
Tavaborole
Tavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed due to Trichophyton rubrum or Trichophyton mentagrophytes infection. Tavaborole functions by inhibiting Leucyl-tRNA synthetase, or LeuRS, an essential fungal enzyme required for protein synthesis and for the catalysis...
Approved
Investigational
Matched Description: … Tavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, ... a fungal infection of the nail and nail bed due to *Trichophyton rubrum* or *Trichophyton mentagrophytes …
Calcium phosphate dihydrate
Approved
Varenicline
Varenicline is a prescription medication used to treat smoking addiction. This medication is the first approved nicotinic receptor partial agonist. Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine receptor. In addition it acts on alpha3/beta4 and weakly on alpha3beta2 and alpha6-containing receptors. A full...
Approved
Investigational
Matched Description: … Varenicline is a prescription medication used to treat smoking addiction. ... A full agonism was displayed on alpha7-receptors.
On March 9, 2015, the U.S. ... Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine …
Soybean oil
Derived from soybeans, soybean oil is a common vegetable oil and a source of polyunsaturated and saturated fatty acids. It is a complex mixture of triglycerides where per 100 g, soybean oil has 16 g of saturated fat, 23 g of monounsaturated fat, and 58 g of polyunsaturated fat. The...
Approved
Matched Description: … Derived from soybeans, soybean oil is a common vegetable oil and a source of polyunsaturated and saturated ... It is used as a cooking oil and lipid emulsion for parenteral nutrition in clinical settings. ... It is a complex mixture of triglycerides where per 100 g, soybean oil has 16 g of saturated fat, 23 g …
Lithium citrate
Approved
Human calcitonin
Calcitonin was first discovered in isolated parathyroid tissue as a substance with a serum-calcium-lowering effect. It is constituted as a 32-amino acid single chain polypeptide structure that gets secreted as a regulatory agent in calcium-phosphorus metabolism. It is used as an alternative for people developing antibodies against salmon calcitonin.
Approved
Investigational
Matched Description: … Calcitonin was first discovered in isolated parathyroid tissue as a substance with a serum-calcium-lowering ... a regulatory agent in calcium-phosphorus metabolism. ... [A32099] It is constituted as a 32-amino acid single chain polypeptide structure that gets secreted as …
Pivmecillinam
Pivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin. [PubChem]
Approved
Matched Description: … Pivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed …
Thyrotropin alfa
Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of...
Approved
Vet approved
Matched Description: … Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests ... It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients ... It is a heterodimeric glycoprotein comprised of two non-covalently linked subunits, an alpha subunit …
Drotrecogin alfa
Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated...
Approved
Investigational
Withdrawn
Matched Description: … a light chain linked by a disulfide bond. ... It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and ... Drotrecogin alfa was withdrawn from the market after a major study indicated that it was not effective …
Cinnamyl alcohol
Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. Due to the low levels found in cinnamon, cinnamyl alcohol is usually supplied as DB14184 within commercial products.
Cinnamyl alcohol has been shown to be a skin sensitizer, with a NOEL (No Effect Level) of ~4% . Sensitivity...
Approved
Experimental
Matched Description: … Cinnamyl alcohol has been shown to be a skin sensitizer, with a NOEL (No Effect Level) of ~4% [A34266 ... Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. ... Sensitivity to cinnamyl alcohol may be identified with a clinical patch test. …
Tiaprofenic acid
Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain. It belongs to the arylpropionic acid (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Approved
Matched Description: … Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly …
Displaying drugs 651 - 675 of 11932 in total