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Displaying drugs 76 - 100 of 11627 in total
Sotorasib
Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.[A187547,A187556] It is indicated in the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer. This mutation makes up >50% of all KRAS mutations. Mutant KRAS discovered in 1982 but was not considered a druggable...
Approved
Investigational
Matched Synonyms: … 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-(1M)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2- methyl ... -4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2(1H)-one …
Matched Iupac: … 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop ... -2-enoyl)piperazin-1-yl]-1H,2H-pyrido[2,3-d]pyrimidin-2-one …
Matched Iupac: … 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop ... -2-enoyl)piperazin-1-yl]-1H,2H-pyrido[2,3-d]pyrimidin-2-one …
Tranylcypromine
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311).
Tranylcypromine is a racemate comprising...
Approved
Investigational
Matched Synonyms: … (±)-trans-2-phenylcyclopropylamine ... trans-2-phenylcyclopropylamine ... trans-DL-2-Phenylcyclopropylamine …
Matched Iupac: … 2-phenylcyclopropan-1-amine …
Matched Description: … Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1- …
Matched Iupac: … 2-phenylcyclopropan-1-amine …
Matched Description: … Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1- …
Telbivudine
Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects.
Approved
Investigational
Matched Synonyms: … 2'-Deoxy-L-thymidine ... β-L-2'-deoxythymidine ... 1-(2-deoxy-β-L-ribofuranosyl)-5-methyluracil …
Matched Iupac: … 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione …
Matched Iupac: … 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione …
Cyclopentolate
A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.
Approved
Matched Synonyms: … 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate ... 2-phenyl-2-(1-hydroxycyclopentyl)ethanoic acid β-(dimethylamino)ethyl ester ... 2-(dimethylamino)ethyl 1-hydroxy-α-phenylcyclopentaneacetate …
Matched Iupac: … 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate …
Matched Iupac: … 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate …
Orphenadrine
A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Approved
Matched Synonyms: … N,N-Dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamine ... 2-methyldiphenhydramine ... 2-(phenyl-o-tolylmethoxy)ethyldimethylamine …
Matched Iupac: … dimethyl({2-[(2-methylphenyl)(phenyl)methoxy]ethyl})amine …
Matched Iupac: … dimethyl({2-[(2-methylphenyl)(phenyl)methoxy]ethyl})amine …
Manganese cation
Manganese is a transition metal that was first described in the 19th and 20th centuries. It is environmentally abundant, being the fifth most abundant metal and the twelfth most abundant element overall on Earth.[A263657, A263667] Manganese intake primarily occurs through the diet, as it is found at low levels in...
Approved
Nutraceutical
Matched Synonyms: … MANGANESE(2+) ... MANGANESE ION(2+) ... MANGANESE CATION (2+) …
Matched Iupac: … manganese(2+) ion …
Matched Mixtures name: … For-2 ... Spectrum 2 Cap ... Master Key Multi Vitamin Multi Mineral Formula 2 …
Matched Iupac: … manganese(2+) ion …
Matched Mixtures name: … For-2 ... Spectrum 2 Cap ... Master Key Multi Vitamin Multi Mineral Formula 2 …
Lamivudine
A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Approved
Investigational
Matched Synonyms: … (-)-2'-Deoxy-3'-thiacytidine ... 2',3'-Dideoxy-3'-thiacytidine ... 3'-Thia-2',3'-dideoxycytidine …
Matched Iupac: … 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one …
Matched Iupac: … 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one …
Oxymetazoline
Oxymetazoline is an imidazole derivative and a potent, direct-acting alpha (α)-adrenergic agonist with affinity to both α1- and α2-adrenoceptors. Oxymetazoline is available in various formulations with a wide variety of clinical implications. The topical formulation of the drug is used to treat persistent facial redness in adults. As an effective...
Approved
Investigational
Matched Synonyms: … 2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline ... 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol ... 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol …
Matched Iupac: … 6-tert-butyl-3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,4-dimethylphenol …
Matched Description: … a potent, direct-acting alpha (α)-adrenergic agonist with affinity to both α1- and α2< …
Matched Categories: … Adrenergic alpha-2 Receptor Agonists …
Matched Iupac: … 6-tert-butyl-3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,4-dimethylphenol …
Matched Description: … a potent, direct-acting alpha (α)-adrenergic agonist with affinity to both α1- and α2< …
Matched Categories: … Adrenergic alpha-2 Receptor Agonists …
Ambrisentan
Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the...
Approved
Investigational
Matched Synonyms: … (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy- 3,3-diphenylpropanoic acid …
Matched Iupac: … (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid …
Matched Iupac: … (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid …
Chloroxylenol
Chloroxylenol, or para-chloro-meta-xylenol (PCMX), is an antiseptic and disinfectant agent used for skin disinfection and surgical instruments. It is found in antibacterial soaps, wound-cleansing applications, and household antiseptics. The halophenol is shown to be most effective against Gram positive bacteria where it disrupts the cell wall due to its phenolic...
Approved
Matched Synonyms: … 2-Chloro-m-xylenol ... 2-chloro-5-hydroxy-m-xylene ... 2-chloro-5-hydroxy-1,3-dimethylbenzene …
Matched Mixtures name: … Multi-action Denorex 2-IN-1 Dandruff Shampoo + Conditioner …
Matched Products: … HACCP Flat Top E-2 ... Pc537 E-2 Brute ... Alpha BAC Stop E-2 …
Matched Mixtures name: … Multi-action Denorex 2-IN-1 Dandruff Shampoo + Conditioner …
Matched Products: … HACCP Flat Top E-2 ... Pc537 E-2 Brute ... Alpha BAC Stop E-2 …
Amiodarone
Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone...
Approved
Investigational
Matched Synonyms: … 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran ... 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone ... 2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran …
Matched Iupac: … {2-[4-(2-butyl-1-benzofuran-3-carbonyl)-2,6-diiodophenoxy]ethyl}diethylamine …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … {2-[4-(2-butyl-1-benzofuran-3-carbonyl)-2,6-diiodophenoxy]ethyl}diethylamine …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Calcium lactate
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is...
Approved
Investigational
Vet approved
Matched Synonyms: … Calcium 2-hydroxypropanoate (1:2) ... 2-Hydroxypropanoic acid calcium salt …
Matched Iupac: … calcium bis(2-hydroxypropanoate) …
Matched Iupac: … calcium bis(2-hydroxypropanoate) …
Glucosamine
Osteoarthritis (OA) is a progressive and degenerative joint disease marked by loss of cartilage, bone changes, and synovial membrane inflammation. Treatment with chondroprotective drugs, such as glucosamine sulfate may offer additional benefits to nonsteroidal anti-inflammatory drugs treating the painful symptoms of OA. Glucosamine is commonly used over the counter as...
Approved
Investigational
Matched Synonyms: … 2-amino-2-deoxy-D-glucose …
Matched Salts cas: … 66-84-2 …
Matched Salts cas: … 66-84-2 …
Clotrimazole
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s . Clotrimazole falls under the imidazole category of azole antifungals, possessing broad-spectrum antimycotic activity . It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As...
Approved
Vet approved
Matched Synonyms: … 1-(α-(2-Chlorophenyl)benzhydryl)imidazole ... 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole …
Matched Iupac: … 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole …
Matched Mixtures name: … LINDAZOL-2 ® ... LINDAZOL-2 ® ... LINDAZOL-2 PLUSS …
Matched Products: … CLOTRIMAZOL 2 % ... CLOTRIMAZOL AL 2% ... CLOTRIMAZOL ARISTO 2% …
Matched Iupac: … 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole …
Matched Mixtures name: … LINDAZOL-2 ® ... LINDAZOL-2 ® ... LINDAZOL-2 PLUSS …
Matched Products: … CLOTRIMAZOL 2 % ... CLOTRIMAZOL AL 2% ... CLOTRIMAZOL ARISTO 2% …
Bosentan
Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.
Approved
Investigational
Matched Synonyms: … p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide ... 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide …
Matched Iupac: … 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl]benzene-1-sulfonamide …
Matched Iupac: … 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl]benzene-1-sulfonamide …
Carbinoxamine
Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and...
Approved
Matched Synonyms: … 2-(p-chloro-α-(2-(dimethylamino)ethoxy)benzyl)pyridine ... {2-[(4-Chloro-phenyl)-pyridin-2-yl-methoxy]-ethyl}-dimethyl-amine …
Matched Iupac: … {2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine …
Matched Description: … unapproved uses (including management of congestion, cough, the common cold, and the use in children under 2 …
Matched Salts cas: … 3505-38-2 …
Matched Iupac: … {2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine …
Matched Description: … unapproved uses (including management of congestion, cough, the common cold, and the use in children under 2 …
Matched Salts cas: … 3505-38-2 …
Betrixaban
Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals...
Approved
Investigational
Matched Synonyms: … N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide ... N-(5-chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide …
Matched Iupac: … N-(5-chloropyridin-2-yl)-2-[4-(N,N-dimethylcarbamimidoyl)benzamido]-5-methoxybenzamide …
Matched Iupac: … N-(5-chloropyridin-2-yl)-2-[4-(N,N-dimethylcarbamimidoyl)benzamido]-5-methoxybenzamide …
Vismodegib
Vismodegib is an orally active small molecule that inhibits the hedgehog signaling pathway by binding to and inhibiting the transmembrane protein smoothened homologue (SMO).[A258613,A258618,L45803] It was discovered by high-throughput screening of a library of small-molecule compounds and subsequent optimization through medicinal chemistry. Since it targets the hedgehog signaling pathway, vismodegib...
Approved
Investigational
Matched Synonyms: … 2-chloro-N-(4-chloro-3-pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide ... Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)- …
Matched Iupac: … 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-methanesulfonylbenzamide …
Matched Iupac: … 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-methanesulfonylbenzamide …
Idursulfase
Idursulfase is a purified form of human iduronate-2-sulfatase, a lysosomal enzyme. Idursulfase is produced by recombinant DNA technology in a human cell line. Idursulfase is an enzyme that hydrolyzes the 2-sulfate esters of terminal iduronate sulfate residues from the glycosaminoglycans dermatan sulfate and heparan sulfate in the lysosomes of various...
Approved
Matched Synonyms: … Iduronate 2-sulfatase …
Matched Description: … Idursulfase is a purified form of human iduronate-2-sulfatase, a lysosomal enzyme. ... Idursulfase is an enzyme that hydrolyzes the 2-sulfate esters of terminal iduronate sulfate residues …
Matched Products: … ELAPRASE 2 MG/ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET …
Matched Description: … Idursulfase is a purified form of human iduronate-2-sulfatase, a lysosomal enzyme. ... Idursulfase is an enzyme that hydrolyzes the 2-sulfate esters of terminal iduronate sulfate residues …
Matched Products: … ELAPRASE 2 MG/ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET …
Phenindione
An indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
Approved
Investigational
Matched Synonyms: … 2-Phenyl-1,3-indandione ... 2-phenyl-1,3-diketohydrindene ... 2-phenyl-1,3(2H)-Indenedione …
Matched Iupac: … 2-phenyl-2,3-dihydro-1H-indene-1,3-dione …
Matched Iupac: … 2-phenyl-2,3-dihydro-1H-indene-1,3-dione …
Panobinostat
Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress of being conducted. Panobinostat...
Approved
Investigational
Matched Synonyms: … 2-PROPENAMIDE, N-HYDROXY-3-(4-(((2-(2-METHYL-1H-INDOL-3-YL)ETHYL)AMINO)METHYL)PHENYL)-, (2E)- ... (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide …
Matched Iupac: … (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Delavirdine
A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.
Approved
Matched Synonyms: … (N-[2-[4-[3-(1-methylethylamino)pyridin-2-yl]piperazin-1-yl]carbonyl-1H-indol-5-yl] methanesulfonamide ... 2-(4-(5-methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-methylethyl)-3-pyridinamine ... N-(2-(1-(3-(isopropylamino)pyridin-2-yl)piperazine-4-carbonyl)-1H-indol-5-yl)methanesulfonamide …
Matched Iupac: … N-[2-(4-{3-[(propan-2-yl)amino]pyridin-2-yl}piperazine-1-carbonyl)-1H-indol-5-yl]methanesulfonamide …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … N-[2-(4-{3-[(propan-2-yl)amino]pyridin-2-yl}piperazine-1-carbonyl)-1H-indol-5-yl]methanesulfonamide …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Florbetaben F-18
Florbetaben is a fluorine-18 (18F)-labeled stilbene derivative used for Positron Emission Tomography (PET) imaging of the brain. It is used for the non-invasive detection of the density of ß-amyloid neuritic plaques in the brain of adult patients with cognitive impairment.
Approved
Matched Synonyms: … 4-((1E)-2-(4-(2-(2-(2-((SUP 18(F))FLUOROETHOXY)ETHOXY)ETHOXY)PHENYL)ETH-1-EN-1-YL)-N-METHYLANILINE …
Matched Iupac: … 4-[(E)-2-[4-(2-{2-[2-(¹⁸F)fluoroethoxy]ethoxy}ethoxy)phenyl]ethenyl]-N-methylaniline …
Matched Iupac: … 4-[(E)-2-[4-(2-{2-[2-(¹⁸F)fluoroethoxy]ethoxy}ethoxy)phenyl]ethenyl]-N-methylaniline …
Levocetirizine
Levocetirizine is a selective histamine H1 antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of cetirizine. Levocetirizine has greater affinity for the histamine H1 receptor than cetirizine. Levocetirizine was granted FDA approval in 1995.
Approved
Matched Synonyms: … 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid …
Matched Iupac: … 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid …
Matched Mixtures name: … Levocetirizine Dihydrochloride 2% / Mupirocin 2% / Triamcinolone Acetonide 0.025% ... Hydrocortisone 2.5% / Levocetirizine Dihydrochloride 2% ... Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Niacinamide 2% …
Matched Iupac: … 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid …
Matched Mixtures name: … Levocetirizine Dihydrochloride 2% / Mupirocin 2% / Triamcinolone Acetonide 0.025% ... Hydrocortisone 2.5% / Levocetirizine Dihydrochloride 2% ... Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Niacinamide 2% …
Felbamate
Felbamate is an anticonvulsant drug used in the treatment of epilepsy. In particular, in the adult patient population, it can be employed to treat partial seizures (with and without generalization). Alternatively, it is used to treat partial and generalized seizures associated with Lennox-Gastaut syndrome in children. It has a weak...
Approved
Matched Synonyms: … 2-phenyl-1,3-propanediol dicarbamate ... carbamic acid 2-phenyltrimethylene ester ... Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester …
Matched Iupac: … 3-(carbamoyloxy)-2-phenylpropyl carbamate …
Matched Iupac: … 3-(carbamoyloxy)-2-phenylpropyl carbamate …
Displaying drugs 76 - 100 of 11627 in total