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Displaying drugs 76 - 100 of 12743 in total
Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down into mesalazine and sulfapyridine, 2 compounds that carry out the main pharmacological...
Approved
Matched Synonyms: … 4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene ... 5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid ... 2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid …
Matched Iupac: … 2-hydroxy-5-[(E)-2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl]benzoic acid …
Matched Description: … Metabolized by intestinal bacteria, sulfasalazine is broken down into [mesalazine] and [sulfapyridine], 2
Matched Categories: … Non COX-2 selective NSAIDS …
Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as the treatment of acromegaly. Bromocriptine has been...
Approved
Investigational
Withdrawn
Matched Synonyms: … 2-bromo-α-ergokryptin ... 2-bromo-α-ergocryptine ... 2-Bromo-alpha-ergocryptine …
Matched Iupac: … (4R,7R)-10-bromo-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-(propan-2-yl)-3-oxa-6,9-diazatricyclo ... -pentaene-4-carboxamide ... [7.3.0.0^{2,6}]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14 …
Matched Categories: … Adrenergic alpha-2 Receptor Agonists ... Heterocyclic Compounds with 4 or More Rings …
Antilipemic agent that lowers cholesterol and triglycerides. It decreases low density lipoproteins and increases high density lipoproteins.
Approved
Investigational
Matched Synonyms: … 2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid …
Matched Iupac: … 2-(4-{2-[(4-chlorophenyl)formamido]ethyl}phenoxy)-2-methylpropanoic acid …
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Approved
Matched Synonyms: … 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid ... 4-(p-bis(beta-chloroethyl)aminophenyl)butyric acid ... 4-(p-bis(β-chloroethyl)aminophenyl)butyric acid …
Matched Iupac: … 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoic acid …
Matched Products: … ลูเคอแรน (เม็ด 2 มก.) ... Leukeran 2 mg - Filmtabletten ... LEUKERAN 2 MG TABLET, 25 ADET …
Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved testing...
Approved
Matched Synonyms: … N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino ... }phenyl)prop-2-enamide …
Matched Iupac: … N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino ... }phenyl)prop-2-enamide …
Matched Description: … Approximately 10% of patients with NSCLC have a rapid and clinically effective response to EGFR-TKIs …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
Approved
Matched Synonyms: … 5-chloro-2-benzoxazolol ... 5-chloro-2-benzoxazolone ... 5-chloro-2-benzoxazolinone …
Matched Iupac: … 5-chloro-2,3-dihydro-1,3-benzoxazol-2-one …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Antazoline is a 1st generation antihistamine with anticholinergic activity. It is used to relieve nasal congestion. It is also formulated as eye drops with naphazoline to relieve allergic conjunctivitis.
Approved
Matched Synonyms: … 2-(N-Benzylanilinomethyl)-2-imidazoline ... 2-(N-Phenyl-N-benzylaminomethyl)imidazoline ... 4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine …
Matched Iupac: … N-benzyl-N-[(4,5-dihydro-1H-imidazol-2-yl)methyl]aniline …
Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem...
Approved
Matched Synonyms: … 4-(Bis(2-chloroethyl)amino)-L-phenylalanine ... 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine ... 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine …
Matched Iupac: … (2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid …
Matched Salts cas: … 3223-07-2
Matched Products: … อัลเคอแรน (เม็ด 2 มก.) ... ALKERAN® 2 MG TABLETAS ... Alkeran 2 mg - Filmtabletten …
Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain. It belongs to the arylpropionic acid (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Approved
Matched Synonyms: … 2-(5-Benzyl-2-thienyl)propionsäure ... 2-(5-Benzoyl-thiophen-2-yl)-propionic acid ... 5-benzoyl-α-methyl-2-thiopheneacetic acid …
Matched Iupac: … 2-(5-benzoylthiophen-2-yl)propanoic acid …
Matched Categories: … Non COX-2 selective NSAIDS …
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve the following group of developmentally...
Approved
Investigational
Matched Synonyms: … methyl phenyl(piperidin-2-yl)acetate ... methyl α-phenyl-α-(2-piperidyl)acetate ... methyl α-phenyl-α-2-piperidinylacetate …
Matched Iupac: … methyl 2-phenyl-2-(piperidin-2-yl)acetate …
Matched Description: … children with ADHD have an abnormality in the dopamine transporter gene (DAT1), the D4 receptor gene (DRD-4) ... Concerta also provides a sustained 10-12 hour effect, allowing for once-daily dosing. ... The MLRTM release system allows for a sustained effect for 10-12 hours, allowing for once-daily dosing …
Matched Salts cas: … 23655-65-4
Matched Products: … PROHIPER 10 ... RUBIFEN 10 MG ... RITALIN ADULT 10 MG …
Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults or combined with tenofovir alafenamide for the prevention of HIV-1 infection in high risk adolescents and adults. Emtricitabine is a cytidine analogue. The drug works by inhibiting HIV reverse transcriptase, preventing transcription of...
Approved
Investigational
Matched Synonyms: … (−)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one ... (2R-cis)-4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone ... 4-amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one …
Matched Iupac: … 5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-4-imino-1,4-dihydropyrimidin-2-ol …
Matched Description: … [L9019] Emtricitabine was granted FDA approval on 2 July 2003.[L9019] …
Matched Mixtures name: … DESCOVY (200/10 MG) ... DESCOVY FILM COATED TABLET 200 MG/10 MG ... DESCOVY 200 MG/ 10 MG FILM KAPLI TABLET, 30 ADET …
Approved
Matched Synonyms: … Iron(2+) gluconate (1:2) ... D-gluconic acid, iron(2+) salt (2:1) …
Matched Iupac: … lambda2-iron(2+) bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate) …
Matched Mixtures name: … Swical-energy-2
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is...
Approved
Investigational
Matched Synonyms: … 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one ... 2',3'-Dideoxycytidine …
Matched Iupac: … 4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one …
Viloxazine is a selective norepinephrine reuptake inhibitor. For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant. It was first approved in the UK in 1974; however, the immediate-release formulation was discontinued due to business reasons unrelated to drug safety and efficacy. In the US,...
Approved
Investigational
Withdrawn
Matched Synonyms: … 2-((2-Ethoxyphenoxy)methyl)morpholine …
Matched Iupac: … 2-[(2-ethoxyphenoxy)methyl]morpholine …
Matched Salts cas: … 35604-67-2
A tetracyclic compound with antidepressant effects. Mianserin was previously available internationally, however in most markets it has been phased out in favour of mirtazapine.
Approved
Investigational
Matched Synonyms: … 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine …
Matched Products: … เมลิน 10 ... เซอริน 10 มก ... MIANSERIN-NEURAX 10 MG …
Vernakalant was developed by Cardiome Pharma as as an antiarrhythmic drug intended for rapid conversion of atrial fibrillation to sinus rhythm. It acts as an atypical class III antiarrhythmic drug that potentiates its effect in higher heart rates. Intravenous formulation was approved in Europe in September 2010 as Brinavess and...
Approved
Investigational
Matched Synonyms: … (3R)-1-((1R,2R)-2-(2-(3,4-dimethoxyphenyl)ethoxy)cyclohexyl)pyrrolidin-3-ol …
Matched Iupac: … (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol …
An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Approved
Investigational
Matched Synonyms: … 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide ... N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide ... N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide …
Matched Iupac: … 4-[(2-methylhydrazin-1-yl)methyl]-N-(propan-2-yl)benzamide …
A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem]
Approved
Matched Synonyms: … 2-(1-piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate ... 2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate ... 2-piperidinoethyl 3-methylflavone-8-carboxylate …
Matched Iupac: … 2-(piperidin-1-yl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate …
Matched Salts cas: … 3717-88-2
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis....
Approved
Investigational
Matched Synonyms: … 2-(2-fluorobiphenyl-4-yl)propanoic acid ... (±)-2-fluoro-α-methyl-4-biphenylacetic acid ... 2-fluoro-α-methyl-(1,1'-biphenyl)-4-acetic acid …
Matched Iupac: … 2-{2-fluoro-[1,1'-biphenyl]-4-yl}propanoic acid …
Matched Categories: … Non COX-2 selective NSAIDS …
Florbetapir (18F) is a radiopharmaceutical compound containing the radionuclide fluorine-18 bound to the compound florbetapir, a molecule that binds with high affinity to beta amyloid plaque, a peptide that plays a key role in Alzheimer's Disease pathogenesis. Marketed as the product Amyvid, florbetapir 18F is indicated for positron emission tomography...
Approved
Investigational
Matched Synonyms: … 4-{(E)-2-[6-(2-{2-[2-(18F)fluoroethoxy]ethoxy}ethoxy)pyridin-3-yl]ethenyl}-N-methylaniline …
Matched Iupac: … 4-[(E)-2-[6-(2-{2-[2-(¹⁸F)fluoroethoxy]ethoxy}ethoxy)pyridin-3-yl]ethenyl]-N-methylaniline …
Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times higher than that of the first generation...
Approved
Investigational
Matched Synonyms: … N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide …
Matched Iupac: … N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide …
Matched Description: … inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID). It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties. It is proposed to be more pharmacologically active and tolerable with a better safety profile than ibuprofen due to higher concentration of active S enantiomer. Dexibuprofen has a...
Approved
Investigational
Matched Synonyms: … (2S)-2-(4-isobutylphenyl)propanoic acid ... (S)-α-methyl-4-(2-methylpropyl)benzeneacetic acid …
Matched Iupac: … (2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid …
Matched Categories: … Non COX-2 selective NSAIDS …
Matched Products: … IBUDEX 400 FILM TABLET, 10 ADET ... TRADIL FORT 400 MG FILM TABLET, 10 ADET …
Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered...
Approved
Vet approved
Matched Synonyms: … (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid ... 6-(2-phenylacetamido)penicillanic acid …
Matched Iupac: … (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid …
Matched Salts cas: … 113-98-4
Matched Mixtures name: … PROKAIN PENICILLIN 3.1.400.000 IU IM ENJEKSİYONLUK TOZ, 10 ADET ... PROKAIN PENICILLIN 3.1.800.000 IU IM ENJEKSİYONLUK TOZ, 10 ADET …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Products: … Retarpen 2,4 Mio. I.E. - Pulver und Lösungsmittel zur Herstellung einer Injektionssuspension ... BENZAPEN LA 1.200.000 IU ENJEKSİYONLUK TOZ, 10 ADET ... BENZAPEN LA 2.400.000 IU ENJEKSİYONLUK TOZ, 10 ADET …
Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as...
Approved
Matched Synonyms: … 2-Hydroxyethyl cellulose ether …
Matched Iupac: … 1-{[3,4,5-tris(2-hydroxypropoxy)-6-{[4,5,6-tris(2-hydroxypropoxy)-2-[(2-hydroxypropoxy)methyl]oxan-3- ... yl]oxy}oxan-2-yl]methoxy}propan-2-ol …
Matched Salts name: … Hydroxyethyl cellulose (100 MPa.s at 2%) ... Hydroxyethyl cellulose (1800 MPa.s at 2%) ... Hydroxyethyl cellulose (280 MPa.s at 2%) ... Hydroxyethyl cellulose (40 MPa.s at 2%) ... Hydroxyethyl cellulose (5500 MPa.s at 2%) …
A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
Approved
Investigational
Matched Synonyms: … }methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ... (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-8-oxo-3-({[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl …
Matched Iupac: … }methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ... (6R,7R)-7-[(2R)-2-hydroxy-2-phenylacetamido]-8-oxo-3-({[1-(sulfomethyl)-1H-1,2,3,4-tetrazol-5-yl]sulfanyl …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Displaying drugs 76 - 100 of 12743 in total