Displaying drugs 76 - 100 of 3051 in total
Kappadione
Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not available in North America . It has been found to have carcinogenic potential in mammalian cells as...
Approved
CVac
Approved
Investigational
Matched Synonyms: … Autologous dendritic cells pulsed with recombinant human fusion protein (MUCIN1 and Glutathione S Transferase …
Aflibercept
Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It...
Approved
Matched Description: … growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin ... Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial …
Matched Categories: … Vascular Endothelial Growth Factor Inhibitor ... Vascular Endothelial Growth Factor Inhibitors …
Matched Categories: … Vascular Endothelial Growth Factor Inhibitor ... Vascular Endothelial Growth Factor Inhibitors …
Nemolizumab
Nemolizumab is a humanized monoclonal modified immunoglobulin 2 (IgG2) antibody directed against interleukin-31 receptor alpha (IL-31RA), which is an endogenous cytokine implicated in the pathophysiology of various skin inflammatory disorders. By binding to IL-31RA, nemolizumab blocks the IL-31 signalling cascades that lead to inflammation. Nemolizumab gained its first global approval...
Approved
Investigational
Matched Synonyms: … with human-Mus musculus monoclonal CIM331 κ-chain, dimer ... Immunoglobulin G2, anti-(interleukin 31 receptor A) (human-Mus musculus monoclonal CIM331 γ-chain), disulfide …
Elranatamab
Elranatamab is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager. It is a humanized immunoglobulin 2-alanine kappa antibody derived from two monoclonal antibodies (mAbs), an anti-BCMA mAb and an anti-CD3 mAb, each of which contributes one heavy chain and one light chain to drug structure. The resulting 4-chain bispecific...
Approved
Investigational
Matched Synonyms: … -CHAIN) (HUMAN-MUS MUSCULUS MONOCLONAL PF-06863059 .GAMMA.2-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS ... IMMUNOGLOBULIN G2 (224-ARGININE,265-ALANINE,330-SERINE,331-SERINE), ANTI-(HUMAN CD3 ANTIGEN .EPSILON. ... T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN CD3E (T-CELL SURFACE ANTIGEN T3/LEU-4 EPSILON CHAIN)), HUMAN-MUS …
Mobocertinib
Mobocertinib is a kinase inhibitor targeted against human epidermal growth factor receptor (EGFR). It is used specifically in the treatment of non-small cell lung cancer (NSCLC) caused by exon 20 insertion mutations in the EGFR gene, which are typically associated with a poorer prognosis (as compared to "classical" EGFR mutants...
Approved
Investigational
Matched Description: … Mobocertinib is a kinase inhibitor targeted against human epidermal growth factor receptor (EGFR). …
Matched Categories: … Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors …
Matched Categories: … Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors …
Burosumab
Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic rickets .
The U.S. Food and Drug Administration approved Crysvita (burosumab) in April 2018. This is the first drug approved...
Approved
Investigational
Matched Description: … Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor …
Matched Categories: … Fibroblast Growth Factor-23 Blocking Antibodies …
Matched Categories: … Fibroblast Growth Factor-23 Blocking Antibodies …
Iptacopan
Iptacopan is a small-molecule factor B inhibitor previously investigated as a potential treatment for the rare blood disease paroxysmal nocturnal hemoglobinuria (PNH) by inhibiting the complement factor B. Factor B is a positive regulator of the alternative complement pathway, where it activates C3 convertase and subsequently C5 convertase. This is...
Approved
Investigational
Matched Description: … Iptacopan is a small-molecule factor B inhibitor previously investigated as a potential treatment for ... the rare blood disease paroxysmal nocturnal hemoglobinuria (PNH) by inhibiting the complement factor ... [A262566] Factor B is a positive regulator of the alternative complement pathway, where it activates …
Tivozanib
Renal cell carcinoma (RCC) is responsible for 3% of cancer cases and is one of the 10 most common cancers in adults. The average age of diagnosis is between age 65 to 74. Tivozanib, also known as FOTIVDA, is a kinase inhibitor developed to treat adult patients with relapsed or...
Approved
Investigational
Matched Categories: … Receptors, Vascular Endothelial Growth Factor, antagonists & inhibitors ... Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors …
Denileukin diftitox
Denileukin diftitox is an IL2-receptor-directed cytotoxin, is a recombinant DNA-derived fusion protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met1-Thr387)-His and the sequence for human interleukin-2 (IL-2; Ala1-Thr133). It is designed to deliver diphtheria toxin into IL-2 receptor-expressing cancer cells to cause cell death.[A264349,...
Approved
Investigational
Matched Synonyms: … L-ALANINE-1-388-TOXIN (CORYNEBACTERIUM DIPHTHERIAE STRAIN C7) (388->2') PROTEIN WITH 2-133-INTERLEUKIN 2 (HUMAN …
Matched Description: … for diphtheria toxin fragments A and B (Met1-Thr387)-His and the sequence for human ... lymphoma (CTCL),[A264339, L51264] making it the first fusion protein cytotoxin approved to treat a human …
Matched Description: … for diphtheria toxin fragments A and B (Met1-Thr387)-His and the sequence for human ... lymphoma (CTCL),[A264339, L51264] making it the first fusion protein cytotoxin approved to treat a human …
Talimogene laherparepvec
Talimogene laherparepvec is an oncolytic treatment used in local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in patients with recurrent melanoma. It is a genetically administered herpes simplex virus 1 (HSV-1) that expresses human cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with antitumor and immune-stimulating activities. It specifically replicates within...
Approved
Experimental
Investigational
Matched Description: … colony stimulating factor (GM-CSF) with antitumor and immune-stimulating activities. ... It is a genetically administered herpes simplex virus 1 (HSV-1) that expresses human cytokine granulocyte-macrophage …
Matched Categories: … Complex Mixtures …
Matched Categories: … Complex Mixtures …
Sulesomab
Market product is Tc99m-labeled murine antibody fragment for nuclear imaging of activated granulocytes.
Approved
Matched Synonyms: … Immunoglobulin G1 (mouse monoclonal IMMU-MN3 Fab' fragment gamma-chain anti-human NCA-90 granulocyte …
Erlotinib
Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)...
Approved
Investigational
Matched Description: … Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used ... Erlotinib binds to the epidermal growth factor receptor (EGFR) tyrosine kinase in a reversible fashion …
Matched Categories: … Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors …
Matched Categories: … Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors …
Daprodustat
Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK.[A254167,A254162] Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces...
Approved
Investigational
Matched Description: … Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that …
Matched Categories: … Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor ... Hypoxia-Inducible Factor-Proline Dioxygenases, antagonists & inhibitors …
Matched Categories: … Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor ... Hypoxia-Inducible Factor-Proline Dioxygenases, antagonists & inhibitors …
Adalimumab
Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor.[A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. This drug is frequently known as Humira. It is produced...
Approved
Experimental
Matched Description: … treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor …
Matched Categories: … Tumor Necrosis Factor Blockers ... Tumor Necrosis Factor Receptor Blocking Activity ... Tumor necrosis factor alpha (TNF-alpha) inhibitors …
Matched Categories: … Tumor Necrosis Factor Blockers ... Tumor Necrosis Factor Receptor Blocking Activity ... Tumor necrosis factor alpha (TNF-alpha) inhibitors …
Sunitinib
Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally available as an orally administered formulation....
Approved
Investigational
Matched Description: … These include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth factor …
Luspatercept
Luspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin receptor type IIB fused to the FC domain of human IgG1.[A187829,L42455] It was first approved for use in the United States in November 2019 under the brand name Reblozyl® for the treatment of anemia in patients...
Approved
Investigational
Matched Description: … comprised of a modified extracellular domain of activin receptor type IIB fused to the FC domain of human …
Matched Categories: … Receptors, Growth Factor ... Receptors, Transforming Growth Factor beta …
Matched Categories: … Receptors, Growth Factor ... Receptors, Transforming Growth Factor beta …
Pyridoxine
Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally present in many foods. As its classification as a vitamin implies, Vitamin B6 (and pyridoxine) are essential nutrients required for normal functioning of many biological systems within the body. While many plants and microorganisms are...
Approved
Investigational
Nutraceutical
Vet approved
Matched Mixtures name: … Complex ... Complex ... Complex …
Matched Categories: … Vitamin B Complex …
Matched Categories: … Vitamin B Complex …
Panthenol
Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Panthenol exists as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol). While pantothenic acid is optically active, only the dextrorotatory...
Approved
Matched Description: … Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an …
Matched Categories: … Vitamin B Complex …
Matched Products: … bdr Re-fine pore minimizing fluid complex …
Matched Categories: … Vitamin B Complex …
Matched Products: … bdr Re-fine pore minimizing fluid complex …
Griseofulvin
An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.
Approved
Investigational
Vet approved
Matched International brands: … Curling factor …
Phylloquinone
Vitamin K1, also called phylloquinone or phytonadione, is a fat soluble vitamin.[L33319,L33345] Phylloquinone is a cofactor of the enzyme γ-carboxylase, which modifies and activates precursors to coagulation factors II, VII, IX, and X.[A234264,A234195,A234259] It is indicated in the treatment of coagulation disorders due to faulty formation of coagulation factors II,...
Approved
Investigational
Matched Description: … [A234264,A234195,A234259] It is indicated in the treatment of coagulation disorders due to faulty formation ... Phylloquinone is a cofactor of the enzyme γ-carboxylase, which modifies and activates precursors to coagulation ... of coagulation factors II, VII, IX, and X caused by deficiency or interference in the activity of vitamin …
Varicella zoster vaccine (live/attenuated)
Live attenuated zoster vaccine is available as two products: Zostavax for the prevention of shingles in immunocompetent people over the age of 50, and Varivax for the prevention of chickenpox in individuals 12 months of age and older. While the two vaccines contain the same immunological components and provide protection...
Approved
Matched Synonyms: … Human herpesvirus 3 live (attenuated) antigen …
Matched Categories: … Complex Mixtures …
Matched Categories: … Complex Mixtures …
Fluticasone
Fluticasone is a synthetic glucocorticoid available as 2 esters, DB08906 and DB00588[F4355,F4358,F4361,F4364][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358,F4361,F4364][FDA Label]. DB00588 was first approved in 1990 and DB08906 was approved in 2007 .
Approved
Experimental
Povidone
Povidone, also known as polyvinylpyrrolidone (PVP) or polyvidone, is a synthetic water-soluble polymer made from the monomer N-vinylpyrrolidone used as a binder in many pharmaceutical tablets and lubricant in eye drops. It is also used in many technical applications with various roles as an adhesive, additive, and emulsifier. When in...
Approved
Withdrawn
Matched Description: … When in complex with iodine, [DB06812] displays antiseptic properties where the iodine, a bactericidal …
Ascorbic acid
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic...
Approved
Nutraceutical
Matched Description: … Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and …
Matched Mixtures name: … C-B Complex ... Iron Complex ... EC + Complex …
Matched Products: … Mega C 500 Complex ... Balanced C Complex ... Mega C500 Complex Tab 500mg …
Matched Mixtures name: … C-B Complex ... Iron Complex ... EC + Complex …
Matched Products: … Mega C 500 Complex ... Balanced C Complex ... Mega C500 Complex Tab 500mg …
Displaying drugs 76 - 100 of 3051 in total