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Displaying drugs 1501 - 1525 of 1875 in total

(10R)-10-formyl-5,8,10-trideazafolic acid

Experimental
Matched Name: … (10R)-10-formyl-5,8,10-trideazafolic acid …

Natalizumab

Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA reintroduced the drug to the...
Approved
Investigational
Matched Description: … In 2006, the FDA reintroduced the drug to the market for multiple sclerosis. ... [A261326] Natalizumab was further approved by the FDA for the treatment of Crohn's Disease in January …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Tysabri Concentrate for Solution for Infusion 300mg/15ml …

Idursulfase

Idursulfase is a purified form of human iduronate-2-sulfatase, a lysosomal enzyme. Idursulfase is produced by recombinant DNA technology in a human cell line. Idursulfase is an enzyme that hydrolyzes the 2-sulfate esters of terminal iduronate sulfate residues from the glycosaminoglycans dermatan sulfate and heparan sulfate in the lysosomes of various...
Approved
Matched Description: … -sulfate esters of terminal iduronate sulfate residues from the glycosaminoglycans dermatan sulfate and ... Idursulfase is a purified form of human iduronate-2-sulfatase, a lysosomal enzyme. …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes …
Matched Products: … ELAPRASE SOLUTION FOR INTRAVENOUS INFUSION ... Elaprase (TM) Solution for Intravenous Infusion 2mg/ ml …

Antithymocyte immunoglobulin (rabbit)

Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of...
Approved
Matched Description: … Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Fluids and Secretions ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Thymoglobuline 5mg/ml Powder for concentrate for solution for infusion …

Carbamazepine

Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1....
Approved
Investigational
Matched Description: … and to treat pain resulting from trigeminal neuralgia. ... Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures …
Matched Categories: … Sodium Channel Blockers …
Matched Products: … CARPIN …

Busulfan

Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought...
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Busulfan Kabi Injection 6mg/ml Concentrate for Solution for Infusion ... Busulfan for Injection ... CANBUSUL- Busulfan Injection 6 mg/ml Concentrate for Solution for Infusion …

Lurbinectedin

Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin (trabectedin), an anticancer agent found in extracts of the tunicate...
Approved
Investigational
Matched Description: … for the treatment of adult patients with metastatic SCLC who have experienced disease progression despite ... including mesothelioma,[A214325] chronic lymphocytic leukemia (CLL),[A214328] breast cancer,[A214322] and ... [L14336] This accelerated approval is based on the rate and duration of therapeutic response observed …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … ZEPZELCA POWDER FOR SOLUTION FOR INFUSION 4MG/VIAL …

Chondroitin sulfate

Chondroitin sulfate is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA). The SYSADOA status suggested a pain relief and increased joint mobility after a relative long regular administration, as well as a long-lasting effect after the end of the treatment. Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine...
Approved
Investigational
Nutraceutical
Matched Description: … [A7906] The SYSADOA status suggested a pain relief and increased joint mobility after a relative long ... Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine and 1,4-β-d-glucuronic ... acid units which bear 4-O- and/or 6-O-sulfations at the N-acetylgalactosamine units disposed of in specific …
Matched Mixtures name: … Blackmores Joint Formula with Glucosamine and Chondroitin ... CARTICAP FOR ... Cosamine Plus Forte M Powder …
Matched Salts name: … Chondroitin sulfate sodium (bovine) ... Chondroitin sulfate sodium (shark) ... Chondroitin sulfate sodium (chicken) ... Chondroitin sulfate sodium (porcine) …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids ... Musculo-Skeletal System …
Matched Products: … HIRUDOID FORT %0,445 JEL, 40 G ... HIRUDOID FORT %0,445 KREM, 40 G …

Blinatumomab

Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostly expressed on the surface of...
Approved
Investigational
Matched Description: … promotes tumor cell lysis and apoptosis. ... recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through ... acute lymphoblastic leukemia (ALL) in relapsed and refractory patients. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … BLINCYTO POWDER FOR INFUSION 35 MCG/VIAL ... BLINCYTO (Blinatumomab) for injection 35 mcg/vial …

Sulfur hexafluoride

Sulfur hexafluoride is an ultrasound contrast agent indicated for use •in echocardiography to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border in adult patients with suboptimal echocardiograms •in ultrasonography of the liver for characterization of focal liver lesions in adult and pediatric...
Approved
Matched Description: … of focal liver lesions in adult and pediatric patients ... the left ventricular chamber and to improve the delineation of the left ventricular endocardial border ... Sulfur hexafluoride is an ultrasound contrast agent indicated for use •in echocardiography to opacify …
Matched Products: … SONOVUE POWDER FOR DISPERSION FOR INJECTION 8 microlitres/ml …

Terlipressin

Terlipressin is a synthetic analogue of vasopressin, which is an endogenous neurohormone that acts as a vasoconstrictor. It is a prodrug of lypressin, or lysine vasopressin. Compared to endogenous vasopressin, terlipressin has a longer half life and increased selectivity for the V1 receptor. As a potent vasopressor, terlipressin has been...
Approved
Investigational
Matched Description: … Compared to endogenous vasopressin, terlipressin has a longer half life and increased selectivity for ... [L43217] As a potent vasopressor, terlipressin has been investigated in various shock states and conditions ... [A2601, A2602, A2603, A2604, A2605] It was also studied in hepatorenal syndrome (HRS) and variceal bleeding …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Pituitary and Hypothalamic Hormones and Analogues ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Sex Hormones and Insulins ... Vasopressin and Analogues …
Matched Products: … GLYPRESSIN FOR INJECTION 1 mg/vial ... GLYPRESSIN 1mg/8.5ml solution for injection ... GLYPRESSIN solution for injection, 1 mg/8.5 ml …

Tetrakis(2-methoxyisobutylisocyanide)copper(I) tetrafluoroborate

Tetrakis (2-methoxyisobutylisocyanide) copper (I) tetrafluoroborate is a component of Cardiolite, a technetium Tc99m-based imaging agent used for assessing myocardial perfusion.
Approved
Matched Description: … copper (I) tetrafluoroborate is a component of Cardiolite, a technetium Tc99m-based imaging agent used for …
Matched Products: … Kit for the Preparation of Technetium Tc99m Sestamibi ... Stamicis Kit for Radiopharmaceutical Preparation 1mg ... STAMICIS 1 mg Kit for Radiopharmaceutical Preparation …

Imiglucerase

Human Beta-glucocerebrosidase or Beta-D-glucosyl-N-acylsphingosine glucohydrolase E.C. 3.2.1.45. 497 residue protein with N-linked carbohydrates, MW=59.3 kD. Alglucerase is prepared by modification of the oligosaccharide chains of human Beta-glucocerebrosidase. The modification alters the sugar residues at the non-reducing ends of the oligosaccharide chains of the glycoprotein so that they are predominantly terminated...
Approved
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes …
Matched Products: … (Imiglucerase) 400U Powder for solution for injection …

Levetiracetam

Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918]...
Approved
Matched Description: … It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated ... having generally narrow therapeutic indexes and a propensity for involvement in drug interactions. ... [L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918] and little-to-no …
Matched Products: … Levetiracetam in Sodium Chloride ... Keppra Concentrate for Solution for Infusion 100 mg/ml ... INTIRACETAM CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/ML …

Paliperidone

Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin...
Approved
Matched Description: … Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic ... therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and ... extended-release tablet, a once-monthly intramuscular injection, an every-three-month intramuscular injection, and …
Matched Products: … INVEGA Sustenna Prolonged Release Suspension for IM Injection 25mg/0.25 ml ... INVEGA Sustenna Prolonged Release Suspension for IM Injection 50mg/0.5 ml ... INVEGA Sustenna Prolonged Release Suspension for IM Injection 75mg/0.75ml …

Azithromycin

Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration . It was initially approved by the FDA in 1991 . It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for...
Approved
Matched Description: … It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be ... used instead of other macrolides for some sexually transmitted and enteric infections. ... Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue …
Matched Categories: … cefixime and azithromycin ... Macrolides, Lincosamides and Streptogramins ... azithromycin, fluconazole and secnidazole ... Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … Zithrolide 500mg Powder for Solution for Infusion ... Azithromycin powder for solution for injection 500mg ... ZITHROMAX IV POWDER FOR SOLUTION FOR INFUSION 500 mg/vial …

Risdiplam

Risdiplam is an orally bioavailable mRNA splicing modifier used for the treatment of spinal muscular atrophy (SMA). It increases systemic SMN protein concentrations by improving the efficiency of SMN2 gene transcription. This mechanism of action is similar to its predecessor nusinersen, the biggest difference being their route of administration: nusinersen...
Approved
Investigational
Matched Description: … substantially cheaper than other available SMA therapies,[L15351] risdiplam appears to provide a novel and ... Risdiplam is an orally bioavailable mRNA splicing modifier used for the treatment of spinal muscular ... relatively accessible treatment option for patients with SMA regardless of severity or type. …
Matched Categories: … Musculo-Skeletal System …
Matched Products: … Evrysdi Powder for oral solution 0.75 mg/mL ... EVRYSDI POWDER FOR ORAL SOLUTION 0.75 MG/ML …

Velaglucerase alfa

Velaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of Type 1 Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase. Additionally, Velaglucerase alfa has also been investigated for use in Type 3 Gaucher disease.
Approved
Investigational
Matched Description: … Velaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of ... Additionally, Velaglucerase alfa has also been investigated for use in Type 3 Gaucher disease. …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes …
Matched Products: … VPRIV POWDER FOR SOLUTION FOR INFUSION 400 UNITS/VIAL …

Cyclophosphamide

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects,...
Approved
Investigational
Matched Description: … Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated ... It has been used in the treatment of lymphoma and leukemia. ... Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. …
Matched Mixtures name: … Procytox for Injection 2000mg Pws IV …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Cytoxan Pws for Inj 1000mg/vial ... Cytoxan Pws for Inj 2000mg/vial ... CYCRAM FOR INJECTION 1 g/vial …

Eribulin

Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for use in the treatment of...
Approved
Investigational
Matched Description: … who have previously received at least two chemotherapeutic regimens for the treatment of metastatic ... Eribulin was isolated from the marine sponge Halichondria okadai. ... Eribulin is also being investigated for use in the treatment of advanced solid tumors [A7439]. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Halaven Solution for Injection 0.5mg/mL ... HALAVEN 0.5 mg/ml solution for injection …

Technetium Tc-99m sulfur colloid

Technetium 99m sulfur colloid is a radiopharmaceutical diagnostic agent used in the evaluation of various conditions including lymph node metastases in breast cancer, detection of shunt patency, imaging of reticuloendothelial cells for assessment of liver function, and studies of esophageal transit and gastroesophageal reflux. Following injection or oral administration, single...
Approved
Investigational
Matched Description: … assessment of liver function, and studies of esophageal transit and gastroesophageal reflux. ... Depending on site of administration and intended usage, Technetium 99m sulfur colloid enters the capillaries ... and is transported to the lymph nodes (subcutaneous injection), mixes with peritoneal fluid (intraperitoneal …
Matched Categories: … Indicators and Reagents ... Hepatic and Reticulo Endothelial System ... Technetium (99Mtc), Particles and Colloids …
Matched Products: … Kit for the Prepartion of Technetium Tc99m Sulfur Colloid ... Kit for the Preparation of Technetium Tc 99m Sulfur Colloid …

Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)

Approved
Investigational
Matched Mixtures name: … -POLIO SUSPENSION FOR INJECTION IN PRE-FILLED SYRINGE ... Tetanus and Diphtheria Toxoids Adsorbed for Adult Use ... Diphtheria and Tetanus Toxoids Adsorbed …
Matched Categories: … Antiinfectives for Systemic Use …
Matched Products: … Diphtheria Toxoid for Reaction Test 0.2lf/ml ... Diphtheria Toxoid for Schick Control 0.2lf/ml …

Mitomycin

Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of Streptomyces caespitosus.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of the DNA double helix. Few other antibiotics have been...
Approved
Matched Description: … [L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations ... , RNA and protein synthesis) by cross-linking the complementary strands of the DNA double helix. ... of cancers - the most recent of which is an April 2020 approval for its use in low-grade Upper Tract …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Indicators and Reagents ... Cytotoxic Antibiotics and Related Substances …
Matched Products: … MITONCO 10mg powder for solution for injection/infusion or intravesical ... Mitomycin for Injection ... Mitomycin for Injection USP …

Eculizumab

Eculizumab is a monoclonal antibody that targets complement protein C5.[L6919,A2245] Binding to this protein prevents the activation of a complement terminal complex, which is used to treat a number of autoimmune conditions.[L6919,A2245,A2246] Eculizumab was granted FDA approval on 16 March 2007. In Q1 2023, the EMA's Committee for Medicinal Products...
Approved
Investigational
Matched Description: … [L6919] In Q1 2023, the EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a positive ... opinion of two formulations of eculizumab indicated for the treatment of paroxysmal nocturnal hemoglobinuria …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Soliris Concentrate for Solution for Infusion 300mg/vial …

Doripenem

Doripenem is a broad-spectrum, carbapenem antibiotic marketed under the brand name Doribax by Janssen. Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal infections. In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin), it was found that...
Approved
Investigational
Matched Description: … to reiterate its safety and efficacy for its approved indications. ... Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal ... In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … Powder for Injection 500mg ... DORIBAX 500 MG (Doripenem) for Injection …
Displaying drugs 1501 - 1525 of 1875 in total