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Displaying drugs 151 - 175 of 14359 in total

Lubiprostone

Lubiprostone is a medication used in the management of idiopathic chronic constipation. A prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of the gastrointestinal epithelial cells. Activation of these channels promotes the secretion of a chloride-rich fluid that soften...
Approved
Investigational
Matched Description: … promotes the secretion of a chloride-rich fluid that soften the stool, increase gastrointestinal motility, and …
Matched Categories: … Alimentary Tract and Metabolism …

Rabeprazole

Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Approved
Investigational
Matched Description: … and stimulated gastric acid secretion. ... Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal …
Matched Categories: … Alimentary Tract and Metabolism ... Antiinflammatory and Antirheumatic Products ... rabeprazole, amoxicillin and metronidazole ... rabeprazole, amoxicillin and clarithromycin ... Topical Products for Joint and Muscular Pain …

Oxyphencyclimine

Oxyphencyclimine is an anticholinergic drug (trade name Daricon) used in treating peptic ulcers.
Approved
Matched Categories: … Alimentary Tract and Metabolism ... oxyphencyclimine and psycholeptics …

Ciprofloxacin

Ciprofloxacin is a second generation fluoroquinolone that has spawned many derivative antibiotics. It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of bacterial infections.[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] The first ciprofloxacin containing product was FDA approved on 22 October 1987.
Approved
Investigational
Matched Description: … [A178870] It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration …
Matched Mixtures name: … Ciprofloxacin and Dexamethasone ... Ciprofloxacin and Dexamethasone ... Ciprofloxacin and Dexamethasone …
Matched Categories: … ciprofloxacin and tinidazole ... ciprofloxacin and ornidazole ... ciprofloxacin and metronidazole ... Ophthalmological and Otological Preparations ... Drug-Related Side Effects and Adverse Reactions …
Matched Products: … Ciprofloxacin and Dextrose ... CILOXAN STERILE OPHTHALMIC AND OTIC SOLUTION 0.3% …

Digitoxin

A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Approved
Investigational

Cyanocobalamin

Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria , and is necessary for DNA synthesis and cellular energy production. Vitamin B12 has many forms, including the cyano-,...
Approved
Nutraceutical
Matched Description: … This vitamin is produced naturally by bacteria [A175276], and is necessary for DNA synthesis and cellular ... Vitamin B12 has many forms, including the cyano-, methyl-, deoxyadenosyl- and hydroxy-cobalamin forms ... The _cyano_ form, is the most widely used form in supplements and prescription drugs [A175255], [FDA …
Matched Mixtures name: … Isotonix Advanced B-complex Vitamins With Potassium and Magnesium ... and Succinic Acid ... Somarexin and C 1000 …
Matched Categories: … Diet, Food, and Nutrition ... Blood and Blood Forming Organs ... Vitamin B12 and Folic Acid ... iron, vitamin B12 and folic acid …

Ivabradine

Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus...
Approved
Matched Description: … is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and ... Although non-dihydropyridine calcium channel blockers and beta blockers also effectively lower heart ... pacemaker current (If) in the sinoatrial node in a dose-dependent fashion, resulting in a lower heart rate and …
Matched Categories: … metoprolol and ivabradine ... carvedilol and ivabradine …

Cefotaxime

Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
Approved
Matched Description: … Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and ... In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. …
Matched Products: … Cefotaxime and Dextrose …

Rocuronium

Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Introduced in 1994, rocuronium has...
Approved
Matched Description: … It is commonly marketed under the trade names Zemuron and Esmeron. ... Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action. ... neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and …

Prednisolone phosphate

Prednisolone phosphate is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone phosphate was granted FDA Approval on 19 December 1973.
Approved
Vet approved
Matched Description: … glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and …
Matched Mixtures name: … Sulfacetamide Sodium and Prednisolone Sodium Phosphate ... Sulfacetamide Sodium and Prednisolone Sodium Phosphate ... Sulfacetamide Sodium and Prednisolone Sodium Phosphate …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Prednisolone acetate

Prednisolone acetate is a prednisolone molecule bound to an acetate functional group by an ester bond. Prednisolone acetate was granted FDA approval in 1955.
Approved
Vet approved

Homatropine methylbromide

Homatropine methylbromide is a quaternary ammonium muscarinic acetylcholine receptor antagonist belonging to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be...
Approved
Matched Description: … It may also be used to prevent nausea, vomiting, and motion sickness. …
Matched Mixtures name: … Hydrocodone Bitartrate and Homatropine Methylbromide ... Hydrocodone Bitartrate and Homatropine Methylbromide ... Hydrocodone Bitartrate and Homatropine Methylbromide …
Matched Categories: … Alimentary Tract and Metabolism ... Belladonna and Derivatives, Plain ... homatropine methylbromide and psycholeptics …

Estradiol

Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches, sprays, gels, and creams.[L11485,L11488,L11491,...
Approved
Investigational
Vet approved
Matched Description: … therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and ... forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches, sprays, gels, and ... Ethinyl estradiol is different from estradiol due to its higher biovailability and increased resistance …
Matched Mixtures name: … Estradiol and Progesterone ... Estradiol and Norethindrone Acetate ... Estradiol and Norethindrone Acetate …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Androgens and Estrogens ... Antiandrogens and Estrogens ... etynodiol and estrogen ... dienogest and estrogen …

Baclofen

Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and...
Approved
Matched Description: … [A245338] Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the ... [L39429] Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence ... used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Glipizide

Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice...
Approved
Investigational
Matched Description: … It was first introduced in 1984 [A179491] and is available in various countries including Canada and ... [A179485] Glipizide was first approved by the FDA in 1994 and is available in extended-release tablets ... onset of action with the shortest half-life and duration of action, reducing the risk for long-lasting …
Matched Mixtures name: … Glipizide and Metformin HCl ... Glipizide and Metformin HCl ... Glipizide and Metformin Hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism …

Mifepristone

Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome....
Approved
Investigational
Matched Description: … Mifepristone is a progestational and glucocorticoid hormone antagonist. ... Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing ... The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg …
Matched Categories: … Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Clarithromycin

Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug...
Approved
Matched Description: … translation and protein assembly process. ... Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the ... Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration …
Matched Mixtures name: … Lansoprazole, Amoxicillin, and Clarithromycin ... Lansoprazole, Amoxicillin and Clarithromycin ... Lansoprazole, Amoxicillin and Clarithromycin …
Matched Categories: … Alimentary Tract and Metabolism ... Erythromycin and similars ... Macrolides, Lincosamides and Streptogramins ... vonoprazan, amoxicillin and clarithromycin ... omeprazole, amoxicillin and clarithromycin …

Isosorbide mononitrate

Isosorbide mononitrate is an organic nitrate with vasodilating properties. It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload.[L11698, L11743] Isosorbide mononitrate is an active metabolite of isosorbide dinitrate. Like other organic nitrates, isosorbide mononitrate...
Approved
Matched Description: … [L11698] It is available in oral tablets generically and under the brand name ISMO and Monoket. ... It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but ... The extended-release forms of the drug are also available generically and under the brand name Imdur. …
Matched Categories: … Nitrates and Nitrites …

Digoxin

Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also...
Approved
Matched Description: … [A178225] It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. ... [A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. ... plant, also known as the _Digitalis_ plant[T610], studied by William Withering, an English physician and …
Matched Categories: … Digoxin and derivatives …

Quizartinib

Quizartinib is an oral and potent fms-like tyrosine kinase 3 (FLT3) inhibitor and it is the first drug developed specifically targeting FLT3, as other agents with FLT3 inhibition activities were investigated with other targets in mind. Additionally, quizartinib also demonstrates inhibitory activity toward FLT3 with internal tandem duplication (ITD), although...
Approved
Investigational
Matched Description: … Quizartinib is an oral and potent fms-like tyrosine kinase 3 (FLT3) inhibitor and it is the first drug ... thus poorer overall survival and higher risk of relapse. ... anthracycline induction and standard cytarabine consolidation, followed by a maintenance monotherapy …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Alfentanil

A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Approved
Illicit
Matched Description: … A short-acting opioid anesthetic and analgesic derivative of fentanyl. ... It produces an early peak analgesic effect and fast recovery of consciousness. ... effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and …
Matched Categories: … Fentanyl and fentanyl analogues …

Cholic Acid

A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. [PubChem] Cholic acid, formulated as Cholbam capsules, is approved by the United States Food and Drug Administration as a treatment for children and adults with bile acid...
Approved
Matched Description: … It facilitates fat absorption and cholesterol excretion. ... enzyme defects, and for peroxisomal disorders (such as Zellweger syndrome). ... A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. …
Matched Categories: … Bile Acids and Salts ... Bile and Liver Therapy ... Bile acids and derivatives ... Alimentary Tract and Metabolism …

Chenodeoxycholic acid

Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decrease the formation...
Approved
Matched Description: … It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol ... in the liver and absorption in the intestines, which helps to decrease the formation of gallstones. …
Matched Categories: … Bile Acids and Salts ... Bile and Liver Therapy ... Bile acids and derivatives ... Alimentary Tract and Metabolism …

Estramustine

A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Docetaxel

Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and non-small cell lung cancer. Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of paclitaxel.[A259676,L46466] Docetaxel reversibly binds to microtubulin with high affinity in a 1:1 stoichiometric...
Approved
Investigational
Matched Description: … Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of [paclitaxel]. ... chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and ... microtubulin with high affinity in a 1:1 stoichiometric ratio, allowing it to prevent cell division and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Oncotaxel Concentrate and solvent for solution for infusion 40 mg/ ml …
Displaying drugs 151 - 175 of 14359 in total