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Displaying targets 101 - 125 of 4415 in total
Nucleobindin-2
Matched Polypeptides general function: … May have a role in calcium homeostasis. …
Kappa-casein
Matched Polypeptides general function: … Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk. …
Leucyl-cystinyl aminopeptidase
Matched Polypeptides general function: … May be involved in the inactivation of neuronal peptides in the brain. ... Binds angiotensin IV and may be the angiotensin IV receptor in the brain. ... Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining …
Megakaryocyte-associated tyrosine-protein kinase
Matched Polypeptides general function: … It may play an inhibitory role in the control of T-cell proliferation. ... Could play a significant role in the signal transduction of hematopoietic cells. ... May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating …
Nuclear receptor subfamily 4 group A member 3
Matched Polypeptides general function: … Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response ... Plays also a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance ... Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription …
6-oxocamphor hydrolase
Matched Polypeptides specific function: … diones such as 2-methyl-2-propylcyclohexa-1,3-dione and 2-methyl-2-butylcyclohexa-1,3-dione which result in …
Matched Polypeptides general function: … Hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances …
Matched Polypeptides general function: … Hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances …
Acyl carrier protein
Matched Polypeptides specific function: … Acp phosphopantetheine attachment site binding involved in fatty acid biosynthetic process …
Matched Polypeptides general function: … Carrier of the growing fatty acid chain in fatty acid biosynthesis. …
Matched Polypeptides general function: … Carrier of the growing fatty acid chain in fatty acid biosynthesis. …
Huntingtin
Matched Polypeptides general function: … May play a role in microtubule-mediated transport or vesicle function. …
Cytochrome P450 2C12, female-specific
Matched Polypeptides general function: … This P450 is active in 15-beta-hydroxylation of steroid sulfates. …
Polyubiquitin-B
Matched Polypeptides general function: … DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in ... is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation ... in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked …
Glutamine synthetase 1
Matched Polypeptides general function: … PLG synthesis in the cell wall occurs only in nitrogen limiting conditions and on the contrary high nitrogen ... PLG synthesis in the cell wall occurs only in nitrogen limiting conditions and on the contrary high nitrogen ... Involved in nitrogen metabolism via ammonium assimilation. …
Free fatty acid receptor 2
Matched Polypeptides general function: … May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain ... In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and ... In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to …
Nucleotide-binding oligomerization domain-containing protein 2
Matched Polypeptides general function: … Involved in gastrointestinal immunity. ... This in turn leads to the transcriptional activation of hundreds of genes involved in immune response ... Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561 …
R2-like ligand binding oxidase
Matched Polypeptides general function: … Probable oxidase that might be involved in lipid metabolism. …
GTP-binding nuclear protein Ran
Matched Polypeptides general function: … GTP-binding protein involved in nucleocytoplasmic transport. ... Involved in chromatin condensation and control of cell cycle (By similarity). …
Serine/threonine-protein kinase LATS1
Matched Polypeptides general function: … Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control ... Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in ... Involved in the control of p53 expression. …
Sodium channel subunit beta-1
Matched Polypeptides specific function: … Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium ... sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in ... mature myelinated axons.Isoform 2: Cell adhesion molecule that plays a critical role in neuronal migration …
Matched Polypeptides general function: … Voltage-gated sodium channel activity involved in purkinje myocyte action potential …
Matched Polypeptides general function: … Voltage-gated sodium channel activity involved in purkinje myocyte action potential …
Myosin-9
Matched Polypeptides general function: … Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such ... During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation ... (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function …
Calcium/calmodulin-dependent protein kinase type 1
Matched Polypeptides general function: … in the adrenal cortex. ... In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. ... Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling …
Protein kinase C gamma type (PRKCG)
Matched Polypeptides general function: … May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal ... May also contributes to chronic morphine-induced changes in nociceptive processing. ... phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in …
Cytochrome b reductase 1
Matched Polypeptides general function: … May be involved in extracellular ascorbate recycling in erythrocyte membranes. ... May also act as a ferrireductase in airway epithelial cells. …
Protein kinase C
Matched Polypeptides specific function: … Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. ... May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with ... In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA …
Matched Polypeptides general function: … In association with FEZ1, stimulates neuronal differentiation in PC12 cells. ... May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal ... Phosphorylates VAMP2 in vitro (PubMed:17313651). …
Matched Polypeptides general function: … In association with FEZ1, stimulates neuronal differentiation in PC12 cells. ... May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal ... Phosphorylates VAMP2 in vitro (PubMed:17313651). …
Sodium channel subunit beta-3
Matched Polypeptides specific function: … sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in …
Matched Polypeptides general function: … Voltage-gated sodium channel activity involved in cardiac muscle cell action potential …
Matched Polypeptides general function: … Voltage-gated sodium channel activity involved in cardiac muscle cell action potential …
Adenylate cyclase
Matched Polypeptides specific function: … May be involved in regulatory processes in the central nervous system. ... May play a role in memory and learning. ... the rhythmic synthesis of cyclic AMP in the retina (By similarity). …
Matched Polypeptides general function: … Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular ... Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in ... Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. …
Matched Polypeptides general function: … Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular ... Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in ... Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. …
Glycogen synthase kinase-3 alpha
Matched Polypeptides general function: … Regulates glycogen metabolism in liver, but not in muscle. ... May be involved in the regulation of replication in pancreatic beta-cells. ... Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose …
Displaying targets 101 - 125 of 4415 in total