Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.

Article Details

Citation

Toll L, Berzetei-Gurske IP, Polgar WE, Brandt SR, Adapa ID, Rodriguez L, Schwartz RW, Haggart D, O'Brien A, White A, Kennedy JM, Craymer K, Farrington L, Auh JS

Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.

NIDA Res Monogr. 1998 Mar;178:440-66.

PubMed ID
9686407 [ View in PubMed
]
Abstract

Not Available

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Dopamine5-hydroxytryptamine receptor 1AProteinHumans
Unknown
Binder
Details
ImipramineD(1) dopamine receptor (Protein Group)Protein groupHumans
Unknown
Binder
Details
Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
Apomorphine5-hydroxytryptamine receptor 1AKi (nM)4929N/AN/ADetails
ApomorphineDopamine D1 receptorKi (nM)400N/AN/ADetails
Bromocriptine5-hydroxytryptamine receptor 1AKi (nM)25N/AN/ADetails
BromocriptineDopamine D1 receptorKi (nM)2070N/AN/ADetails
BuprenorphineDelta-type opioid receptorKi (nM)4.5N/AN/ADetails
BuprenorphineKappa-type opioid receptorKi (nM)0.8N/AN/ADetails
Chlorpromazine5-hydroxytryptamine receptor 1AKi (nM)3115N/AN/ADetails
ChlorpromazineDopamine D1 receptorKi (nM)44N/AN/ADetails
Desipramine5-hydroxytryptamine receptor 1AKi (nM)>10000N/AN/ADetails
DiprenorphineDelta-type opioid receptorKi (nM)0.5N/AN/ADetails
DiprenorphineKappa-type opioid receptorKi (nM)0.2N/AN/ADetails
Dopamine5-hydroxytryptamine receptor 1AKi (nM)8248N/AN/ADetails
DopamineDopamine D1 receptorKi (nM)4470N/AN/ADetails
FentanylDelta-type opioid receptorKi (nM)152.7N/AN/ADetails
FentanylKappa-type opioid receptorKi (nM)84.8N/AN/ADetails
FlupentixolDopamine D1 receptorKi (nM)3N/AN/ADetails
FluphenazineDopamine D1 receptorKi (nM)7N/AN/ADetails
HaloperidolDopamine D1 receptorKi (nM)58N/AN/ADetails
Imipramine5-hydroxytryptamine receptor 1AKi (nM)>10000N/AN/ADetails
Mianserin5-hydroxytryptamine receptor 1AKi (nM)2592N/AN/ADetails
MorphineDelta-type opioid receptorKi (nM)140N/AN/ADetails
MorphineKappa-type opioid receptorKi (nM)46.9N/AN/ADetails
NaloxoneDelta-type opioid receptorKi (nM)67.5N/AN/ADetails
NaloxoneKappa-type opioid receptorKi (nM)2.5N/AN/ADetails
PentazocineKappa-type opioid receptorKi (nM)2.2N/AN/ADetails
Propranolol5-hydroxytryptamine receptor 1AKi (nM)272N/AN/ADetails
Yohimbine5-hydroxytryptamine receptor 1AKi (nM)642N/AN/ADetails