Membrane Transport Modulators
- Name
- Membrane Transport Modulators
- Accession Number
- DBCAT000128
- Description
Agents that affect ION PUMPS; ION CHANNELS; ABC TRANSPORTERS; and other MEMBRANE TRANSPORT PROTEINS.
- Drugs
Drug Drug Description Ajmaline An antiarrhythmic used to manage a variety of forms of tachycardias. Alaproclate Alaproclate was developed as one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in the 1970s. Development was discontinued due to concerns over hepatotoxicity... AM336 Investigated for use/treatment in pain (acute or chronic). Amifampridine A voltage gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome. Amiloride A pyrizine compound used to treat hypertension and congestive heart failure. Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Amlodipine A calcium channel blocker used to treat hypertension and angina. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Amphetamine A CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Amrinone A positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure. Apinocaltamide Apinocaltamide is under investigation in clinical trial NCT03239691 (A Study to Evaluate the Effect of ACT-709478 in Photosensitive Epilepsy Patients). Aprindine Aprindine is a cardiac depressant used in arrhythmias. Atomoxetine A selective norepinephrine reuptake inhibitor (SNRI) used in the management of Attention Deficit Hyperactivity Disorder (ADHD). Azimilide Investigated for use/treatment in arrhythmia and atrial fibrillation. Bamocaftor Bamocaftor (VX-659) is under investigation in clinical trial NCT03224351 (A Study Evaluating the Safety and Efficacy of VX-659 Combination Therapy in Subjects With Cystic Fibrosis). Barnidipine A calcium channel blocker used to treat various forms of hypertension. Bencyclane A vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels. Bendroflumethiazide A diuretic used to suppress lactation and to treat hypertension and edema. Benidipine A synthetic dihydropyridine calcium channel blocker used to treat hypertension and angina pectoris. Benzatropine An anticholinergic drug used to treat Parkinson's disease (PD) and extrapyramidal symptoms, except tardive dyskinesia. Benzphetamine A sympathomimetic used to manage exogenous obesity short term. Bepridil For the treatment of hypertension, and chronic stable angina (classic effort-associated angina). Berbamine Not Annotated Botulinum toxin type A A purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications. Botulinum toxin type B A purified form of botulinum toxin type B used to block acetylcholine release in the treatment of cervical dystonia and sialorrhea. Bumetanide A sulfamyl diuretic used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome. Calcimycin Calcimycin is an ionophore and polyether antibiotic derived from Streptomyces chartreusensis. It binds to and transports calcium and other divalent cations across membranes, disrupts oxidative phosphorylation, and inhibits ATPase in... Calcitriol An active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia. Carbamazepine An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia. Carboxyamidotriazole Carboxyamidotriazole has been used in trials studying the treatment of Lymphoma, Lung Cancer, Breast Cancer, Kidney Cancer, and Ovarian Cancer, among others. Caroverine A calcium channel blocker indicated in the treatment of smooth muscle spasms, alcohol and drug withdrawal, and tinnitus. Carvedilol A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. Centanafadine A once-daily norepinephrine-dopamine-serotonin reuptake inhibitor and CNS stimulant indicated for ADHD in adults and pediatric patients. Chlorothiazide A thiazide diuretic used to treat hypertension and edema in congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Chlorthalidone A diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions. Cilnidipine A dihydropyridine calcium channel blocker with action on both N- and L-type calcium channels used to treat hypertension. Cinnarizine A drug used for the management of labyrinthine disorder symptoms, including vertigo, tinnitus, nystagmus, nausea, and vomiting. Clamikalant Clamikalant is a small molecule drug. The usage of the INN stem '-kalant' in the name indicates that Clamikalant is a potassium channel blocker. Clamikalant has a monoisotopic molecular weight... Clevidipine A dihydropyridine L-type calcium channel blocker used to lower blood pressure when oral antihypertensive therapy is not feasible or not desirable. Clomipramine A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Cocaine An ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities. Cyclo(his-pro) Not Available Cyclopenthiazide Cyclopenthiazide is a thiazide diuretic with antihypertensive properties. In a double blind, randomized crossover study, cyclopenthiazide was effective in reducing diastolic blood pressure in mildly hypertensive non-insulin dependent diabetic patients... Dalfampridine A potassium channel blocker used for the improvement of motor function in patients with multiple sclerosis (MS). Darodipine Darodipine is a calcium channel blocker. Desipramine A tricyclic antidepressant used in the treatment of depression. Desvenlafaxine An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. Dexmethylphenidate A norepinephrine-dopamine reuptake inhibitor used in the treatment of ADHD in conjunction with other therapies. Dexniguldipine Not Annotated Dextroamphetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Dexverapamil Not Annotated Diltiazem A calcium channel blocker used to treat hypertension and to manage chronic stable angina. Disopyramide A class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. Dofetilide A class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter. Dosulepin A tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential. Dotarizine A calcium antagonist used to treat and prevent migraines. Duloxetine A serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. Efonidipine For the treatment of hypertension. Elexacaftor A small molecule CFTR corrector used in combination with tezacaftor and ivacaftor for the treatment of cystic fibrosis patients with one F508del-CFTR mutation. Emopamil Prevents renal injury after warm & cold ischemia. Encainide A voltage-gated sodium channel blocker used for management of atrial or ventricular fibrillation, atrial flutter, and ventricular tachycardia, that is no longer used due to proarrhythmic adverse effects. Eperisone An antispasmodic that functions through voltage-gated channel blockade, notably with little to no sedation, effective in relaxing skeletal muscles and vascular smooth muscles. Escitalopram A selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). Eslicarbazepine An antiepileptic indicated as a monotherapy or adjunct therapy in the treatment of epilepsy. Eslicarbazepine acetate An anticonvulsant agent used as an adjunct to treat partial-onset seizures in patients with inadequate clinical response to conventional antiepileptic therapy. Ethotoin A hydantoin antiepileptic used to control tonic-clonic and complex partial seizures. Etripamil An L-type calcium channel blocker used to convert acute symptomatic episodes of paroxysmal supraventricular tachycardia to sinus rhythm in adults. Ezogabine An antiepileptic agent used as an adjuvant treatment of partial-onset seizures. Falipamil Falipamil is a small molecule drug. Falipamil has a monoisotopic molecular weight of 428.23 Da. Fantofarone Fantofarone is a small molecule drug. Fantofarone has a monoisotopic molecular weight of 550.25 Da. Fasudil Fasudil has been investigated in Carotid Stenosis. Felodipine A calcium channel blocker used to treat hypertension. Femoxetine Femoxetine is a small molecule drug. Femoxetine has a monoisotopic molecular weight of 311.19 Da. Fendiline Fendiline is a coronary vasodilator which inhibits calcium function in muscle cells in excitation-contraction coupling. It has been proposed as an antiarrhythmic and antianginal agent. Fendiline is non-selective. Fenfluramine Fenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures. Flecainide A class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT). Flunarizine A selective calcium-entry blocker used as migraine prophylaxis in patients with severe and frequent episodes who have not responded adequately to more common treatments. Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Fosphenytoin An antiepileptic agent used for the management of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery. Fostedil Fostedil is a small molecule drug. The usage of the INN stem '-dil' in the name indicates that Fostedil is a vasodilator. Fostedil has a monoisotopic molecular weight of 361.09... Furosemide A loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. Gallopamil Gallopamil has been used in trials studying the treatment of Asthma. GBR-12783 A selective inhibitor of dopamine uptake. Hydrochlorothiazide A thiazide diuretic used to treat edema associated with a number of conditions, and hypertension. Hydroflumethiazide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Indalpine Indalpine was one of the first selective serotonin reuptake inhibitors to reach the American market. It was initially marketed by Pharmuka. However, after the emergence of widespread concern regarding adverse... Indapamide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure. Isradipine A dihydropyridine calcium channel blocker used for the treatment of hypertension. Ivacaftor A cystic fibrosis transmembrane conductance regulator (CFTR) potentiator used alone or in combination products to treat cystic fibrosis in patients who have specific genetic mutations that are responsive to the medication. Lacidipine A lipophilic dihydropyridine calcium channel blocker with a slow onset of action used to treat hypertension. Lacosamide An antiepileptic drug used to treat partial-onset seizures and primary generalized tonic-clonic seizures. Lamotrigine A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder. Lasalocid Lasalocid is an agent that presents antibacterial and coccidiostat activities. It is produced by strains of Streptomyces lasaliensis. Lercanidipine A calcium channel blocker for the management of hypertension. LetibotulinumtoxinA A purified type A botulinum neurotoxin protein complex used to improve the appearance of glabellar lines. Levomilnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD) in adults. Levosemotiadil Levosemotiadil is a small molecule drug. The usage of the INN stem '-dil' in the name indicates that Levosemotiadil is a vasodilator. Levosemotiadil has a monoisotopic molecular weight of 536.2... Lidocaine A local anesthetic used in a wide variety of superficial and invasive procedures. Lidoflazine Not Annotated Linopirdine Not Annotated Lisdexamfetamine A central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) and moderate to severe eating disorders. Lomerizine Lomerizine is a diphenylmethylpiperazine calcium channel blocker with relatively selective central nervous system (CNS) effects. This drug is used to prophylactically treat migraines and is also being investigated against eye-related... Lubiprostone A prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use. Magnesium sulfate A drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany. Manidipine A dihydropyridine calcium channel blocker used to treat hypertension. Maprotiline A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression. Mazindol A sympathomimetic used to treat obesity in combination with lifestyle modifications. Metamfetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. Methyclothiazide A diuretic drug used to treat hypertension and edema caused by heart failure, renal conditions, treatment with corticosteroids, and estrogen therapy. Methylenedioxyethamphetamine Not Available Methylphenidate A stimulant used in the management of Attention Deficit Hyperactivity Disorder (ADHD). Metolazone A thiazide-like diuretic used to treat hypertension. Mexiletine A class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment. Mibefradil For the treatment of angina and high blood pressure. Midomafetamine Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used... Milnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of fibromyalgia and a short-term treatment of major depressive disorder. Monensin Monensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds. Moricizine An antiarrhythmic used to treat arrhythmias. Naftopidil Naftopidil has been investigated for the treatment of Disorder of Urinary Stent. Nefazodone An antidepressant used in the treatment of depression. Nicardipine A calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. Nifedipine A dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension. Nigericin A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed) Niguldipine Niguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties. Niludipine Niludipine is a calcium channel blocker. Nilvadipine A calcium channel blocker used to manage arterial hypertension. Nimodipine A calcium channel blocker used to improve neurological outcomes in patients with subarachnoid hemorrhage due to a ruptured intracranial aneurysm. Nisoldipine A calcium channel blocker used as monotherapy or combined with other drugs for the treatment of hypertension. Nitrendipine A dihydropyridine calcium channel blocker indicated in the treatment of arterial hypertension. Nomifensine Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA... Nortriptyline A tricyclic antidepressant used in the treatment of depression. Nystatin A polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species. Opipramol A medication to treat general anxiety and somatoform disorders. Otilonium A spasmolytic medication used to treat irritable bowel syndrome (IBS). Oxcarbazepine An anti-epileptic used in the treatment of partial-onset seizures. Paroxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. Perhexiline For the management of severe angina pectoris. Phenytoin An anticonvulsant drug used in the prophylaxis and control of various types of seizures. Pilsicainide Pilsicainide has been investigated for the treatment of Paroxysmal Atrial Fibrillation. Pinacidil Pinacidil is a cyanoguanidine drug that acts by opening ATP-sensitive potassium channels, leading to peripheral vasodilatation of arterioles and decreasing peripheral vascular resistance. The above processes result in reduced blood... Pinaverium A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract. Piretanide A loop diuretic used to manage essential arterial hypertension and edema cardiac, hepatic, and renal origin. Polythiazide A thiazide diuretic used in the management of hypertension and treatment of edema. Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Prenylamine Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias. Procainamide A medication used to treat life threatening ventricular arrhythmias. Propafenone A Class 1C antiarrhythmic agent used in the management of paroxysmal atrial fibrillation/flutter and ventricular arrhythmias. Protriptyline A tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision. Quinethazone Used to treat hypertension. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Ranolazine An anti-anginal drug used for the treatment of chronic angina. Reboxetine A drug used for the acute treatment of major depression and for maintenance therapy of depression. Reserpine For the treatment of hypertension Riodipine Riodipine is a small molecule drug. The usage of the INN stem '-dipine' in the name indicates that Riodipine is a calcium channel blocker, nifedipine derivative. Riodipine has a monoisotopic... Risedronic acid A bisphosphonate used to treat osteoporosis and Paget's disease. Rufinamide An antiepileptic drug used as adjunctive therapy to treat seizures associated with Lennox-Gastaut Syndrome (LGS). Semotiadil Semotiadil is a small molecule drug. The usage of the INN stem '-dil' in the name indicates that Semotiadil is a vasodilator. Semotiadil has a monoisotopic molecular weight of 536.2... Serdexmethylphenidate A prodrug of the CNS stimulant dexmethylphenidate used as a first-line treatment for Attention Deficit Hyperactivity Disorder (ADHD). Sertraline A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. Sipatrigine Sipatrigine is a small molecule drug. The usage of the INN stem '-trigine' in the name indicates that Sipatrigine is a sodium channel blocker, signal transduction modulator. Sipatrigine has a... SKF-96365 free base SKF-96365 is a receptor-mediated calcium entry (RMCE) inhibitor structurally different from other calcium antagonists. SOR-C13 SOR-C13 is under investigation in clinical trial NCT01578564 (Safety and Tolerability Study of SOR-C13 in Subjects With Advanced Cancers Commonly Known to Express the TRPV6 Channel). Suzetrigine A sodium channel blocker used to treat moderate to severe acute pain in adults. Tapentadol An opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate. Tenamfetamine An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons... Terodiline Not Annotated Tetrabenazine A vesicular monoamine transporter 2 (VMAT) inhibitor used for the management of chorea associated with Huntington's Disease. Tetraethylammonium Tetraethylammonium is an experimental drug with no approved indication. Tetrahydropalmatine Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). Tetrandrine Not Annotated Tetrodotoxin For the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence. Tiagabine An antiepileptic used to treat partial seizures. Tiapamil Tiapamil is a small molecule drug. Tiapamil has a monoisotopic molecular weight of 555.2 Da. Tocainide An orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias. Tolfenamic acid In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults. Torasemide A diuretic used to treat hypertension and edema associated with heart failure, renal failure, or liver disease. Tranilast For the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Triamterene A potassium-sparing diuretic used in the treatment of edema and in the management of hypertension. Trichlormethiazide Used in the treatment of oedema (including that associated with heart failure) and hypertension. Trimipramine A tricyclic antidepressant used to treat depression. Tripamide Not Annotated Tyramine Tyramine (4-hydroxyphenethylamine; para-tyramine, mydrial or uteramin) is a naturally occurring monoamine compound and trace amine derived from the amino acid tyrosine. Tyramine acts by inducing the release of catecholamine. An... Ulixacaltamide Not Available Valinomycin A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately... Vanoxerine An investigational dopamine transporter antagonist suggested to be beneficial in the treatment of cocaine addiction. Venlafaxine A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression, generalized or social anxiety disorder, and panic disorder. Verapamil A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. Vilazodone An antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors. Viloxazine A selective norepinephrine reuptake inhibitor indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in adults in children. Vortioxetine A serotonin modulating antidepressant indicated for the treatment of major depressive disorder (MDD). WIN 55212-2 WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. It... Z-160 Z160 has been used in trials studying the treatment of Postherpetic Neuralgia and Lumbosacral Radiculopathy. Ziconotide An N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics. Zimelidine For the treatment of depression. Zonisamide A sulfonamide anticonvulsant used to treat partial seizures. - Drugs & Drug Targets