HIV Fusion Inhibitors

HIV Fusion Inhibitors
Accession Number

Inhibitors of the fusion of HIV to host cells, preventing viral entry. This includes compounds that block attachment of HIV ENVELOPE PROTEIN GP120 to CD4 RECEPTORS.

DrugDrug Description
EnfuvirtideAn HIV-1 gp41 fusion inhibitor used in patients experiencing HIV-1 replication who are already being treated with other anti-retrovirals.
MaravirocA CCR5 co-receptor antagonist used with other antiretroviral medications to treat CCR5-tropic HIV-1 infection.
BMS-488043Investigated for use/treatment in HIV infection.
PRO-542Investigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections, HIV infection, and pediatric indications.
LeronlimabA humanized monoclonal antibody being investigated
AplavirocInvestigated for use/treatment in HIV infection.
IbalizumabA CD4-specific antibody used to treat HIV infections.
TemsavirNot Annotated
FostemsavirAn antiretroviral HIV-1 attachment inhibitor targeted against the gp120 subunit within the HIV-1 gp160 envelope glycoprotein.
Drugs & Drug Targets
EnfuvirtideEnvelope glycoproteintarget
EnfuvirtideCytochrome P450 2C19enzyme
EnfuvirtideCytochrome P450 2E1enzyme
MaravirocC-C chemokine receptor type 5target
MaravirocCytochrome P450 3A4enzyme
BMS-488043Free fatty acid receptor 4target
PRO-542Free fatty acid receptor 4target
LeronlimabC-C chemokine receptor type 5target
AplavirocC-C chemokine receptor type 5target
IbalizumabT-cell surface glycoprotein CD4target
IbalizumabC-C chemokine receptor type 5target
IbalizumabC-X-C chemokine receptor type 4target
FostemsavirCytochrome P450 3A4enzyme
FostemsavirUDP-glucuronosyltransferases (UGTs)enzyme
FostemsavirP-glycoprotein 1transporter
FostemsavirATP-binding cassette sub-family G member 2transporter
FostemsavirSolute carrier organic anion transporter family member 1B1transporter
FostemsavirSolute carrier organic anion transporter family member 1B3transporter
FostemsavirSerum albumincarrier
FostemsavirEnvelope glycoprotein gp160target