Antifungals for Systemic Use

All categories
Name
Antifungals for Systemic Use
Accession Number
DBCAT002359
Description

Antifungals which are used systemically, meaning they penetrate the circulatory system and impact the entire body.

ATC Classification
Drugs
DrugDrug Description
GriseofulvinAn antifungal agent used to treat a variety of superficial tinea infections and fungal infections of the fingernails and toes.
TerbinafineAn allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections.
FosravuconazoleFosravuconazole is under investigation in clinical trial NCT03378661 (BENDITA BEnznidazole New Doses Improved Treatment and Associations).
Drugs & Drug Targets
DrugTargetType
GriseofulvinKeratin, type I cytoskeletal 12target
GriseofulvinCytochrome P450 1A2enzyme
GriseofulvinCytochrome P450 3A4enzyme
GriseofulvinTubulin beta chaintarget
TerbinafineSqualene monooxygenasetarget
TerbinafineCytochrome P450 2D6enzyme
TerbinafineCytochrome P450 2C9enzyme
TerbinafineCytochrome P450 1A2enzyme
TerbinafineCytochrome P450 3A4enzyme
TerbinafineCytochrome P450 2C8enzyme
TerbinafineCytochrome P450 2C19enzyme
TerbinafineProstaglandin G/H synthase 1enzyme
TerbinafineAlbumincarrier
Terbinafinealpha1-acid glycoproteincarrier
TerbinafineABC multidrug transporter MDR2transporter
TerbinafineSqualene monooxygenasetarget